Protein Alignment MRP and mrp-7

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_507812.3
• Gene: mrp-7 / 180289
• WormBaseID: WBGene00003413
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1580
• Identity: 663/1580 - (41%)
• Similarity: 964/1580 - (61%)
• Gaps: 105/1580 - (6%)

  Fly     9 MDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFY----YLKASLDRNIPW 69
            :..|||.     ...:.|..|:.:.|.:.|.|||.|.||:  .:...|.    :|.|.....:|:
 Worm     2 LSSFCGD-----GHPFSTGLPNVSICAQHTVLVWVPAAFF--LLTLPFLSAQCHLTAQRFARLPF 59

  Fly    70 NKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKY 134
            :...:.|.|:...|...:.......|..|...:........:| .::...|||:..|.:    :.
 Worm    60 SAHFIIKLLLVAFLAANSLATWCYVLFSKNSYAAAYYVYPGLW-VLVWTGTFLVHLIRL----RC 119

  Fly   135 GVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSF-------- 191
            |:.::|.|.:...:..:...|.....:|::       ||........:.:..||:|.
 Worm   120 GLVSSGIQHVTSLIFLLCGAPEFYQWIRME-------NSNSFPNDLTTTDSAQFLSIAYLSWYSA 177

  Fly   192 FIFFTFTSIMLILNCFADGMPRQTKYQRGENE---IPELSASFLSRITYQWFDKMALKGYRNPLE 253
            .|.:||:.      ||||....:|..::..::   .|||.:|||:|:|..||:.:...|.|..||
 Worm   178 LILYTFSL------CFADPRGAKTDDEKASSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLE 236

  Fly   254 EKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNK----ARVEPKAQFSNGNVTFENPHGEKNGR 314
            ..|:::|..:.....:..::...|... |..|.:.    |:.:|..|..:..|
 Worm   237 IDDIFELNERSGTEFLSELWESFWEPK-RLKYIHDTSIWAKKDPSEQEKDPVV------------ 288

  Fly   315 KKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLL 379
               :.|::..::..|...||..:.:|..:||:.||.|.:|..:::|:.|::| |.|||:..::|:
 Worm   289 ---IPSVVSSLFMMFRWEFLLASTLKFVSDTMQFASPFLLHELLNFISAKNA-PFWKGMALSILM 349

  Fly   380 FVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFM 444
            |.::..::.||..||:.||.:|.:|:|:|..|:|:|.|.||||.:::.||||||||||:|.:||.
 Worm   350 FSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLLISNSARRDRTVGEIVNLMAIDVERFQ 414

  Fly   445 ELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDE 509
            .:|..:...||.|.||..||.:|:..||.|.|.|:.:|:|.:|:|.:.:..::.:||.|||.|||
 Worm   415 MITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIFVPMNIISSMIVRKWQIEQMKLKDE 479

  Fly   510 RVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTF 574
            |.|::||||:||||:||||||...|..:.:||.||:|.::.:|.:........:.:||||:|.:|
 Worm   480 RTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKSAMVRNILDSFNTASPFLVALFSF 544

  Fly   575 ATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSV 639
            .|:||::.::.|:.:...||:|||:.::.|:|::.:|.....:..||..|:.:||.:||||...|
 Worm   545 GTFVLSNPSHLLTPQIAFVSLALFNQLRSPMTMIALLINQAVQAVVSNKRLKEFLVAEELDEKCV 609

  Fly   640 ---LHDSSKPHPMSIENGEFSW-----GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLG 696
               ::.....:.:.:||...||     ..|.||:::::...:.||:|:||.|||||||::||.||
 Worm   610 DRSVNIERSHNAVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLG 674

  Fly   697 EMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDL 761
            ||.||.|.:...|::||||||.||||.|:||||.||:.:|||||::|:.||||:|||.||.|||.
 Worm   675 EMGKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQ 739

  Fly   762 TEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRV 826
            |||||||||||||||.|:|||||||.:.|:|||||||||||||||:||||:||||.|:|..|:|:
 Worm   740 TEIGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRI 804

  Fly   827 LVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQH-------LQEGNEEEEELN 884
            |||||:|:....|.|.|:..|:|.|||||:.|:|.:|.|.||:.::       .:.|..::::..
 Worm   805 LVTHGLTYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFE 869

  Fly   885 QIKRQISSTADVPELLGTVEKAI-KLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVA 948
            .|..:|....:..:::.||...: :..||..|:..||..|:             .::..:..|.|
 Worm   870 AIGGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSS-------------PEKPPTGTSPA 921

  Fly   949 SAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLT 1013
            :|.      |.:.|||:.|....|.||.|.|:.|:|:.|..||:|.:....|:...||..:.||:
 Worm   922 AAT------ESQNKLIKKEGIAQGKVEIATYQLYVKAAGYLLSIAFIGFFIVYMTLQILRSFWLS 980

  Fly  1014 QWANDQNVANDTG---LRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRG 1075
            .|:::.:..:.:.   .:...||||||.||.:....:.|::.:...|.:|:|.:|..|:..::|
 Worm   981 AWSDEYDPDSPSAHPMAKGWRLGVYGALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMR- 1044

  Fly  1076 SVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIA 1140
            |...|:|.||:||:||..:.|::.:|..||......:..:..|..|::||.:|||:|..||:|:|
 Worm  1045 SPMSFYDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLA 1109

  Fly  1141 FLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVC 1205
            .:|....|:||.|||||.|||||.||||||||.||:.||::|||:...|.|.::|...:|....|
 Worm  1110 LIYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRC 1174

  Fly  1206 KYPSVIANRWLAIRLEMVGNLIILFASLFAVL----GGQTNPGLVGLSVSYALQVTQTLNWLVRM 1266
            :|.|:::|||||:|||.|||.||.||:|||||    |..|:||::|:||||||.:|:.||:.||.
 Worm  1175 RYSSLVSNRWLAVRLEFVGNCIIFFAALFAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQ 1239

  Fly  1267 SSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVS 1331
            .|:||.|||||||:.||..|..||||.:|..:..| .||..|.|:|..:..||||||||||..:|
 Worm  1240 VSEIEANIVSVERVNEYTNTPNEAPWRIEGREPAP-GWPSRGVVKFDGYSTRYREGLDLVLHDIS 1303

  Fly  1332 FNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVL 1396
            .::..|||:||||||||||||..|||||:||||||||.||.|:::.:|||.|||.:|||||||||
 Worm  1304 ADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVL 1368

  Fly  1397 FSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARAL 1461
            |||:||.|||||...:||:||:||||:|||.|...|..||.::|:|.||||||||||||.|||||
 Worm  1369 FSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARAL 1433

  Fly  1462 LRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFA 1526
            ||.|:||||||||||||:.||.|||:|||.|||||||.|||||||||:|.|:::|||||.|:||.
 Worm  1434 LRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFD 1498

  Fly  1527 SPTELLDNPKSAFYSMAKDA 1546
            :|..|:.:..|||..|..||
 Worm  1499 TPDALMADKNSAFAKMVADA 1518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	661/1575 (42%)
		ABC_membrane	338..601	CDD:279056	111/262 (42%)
		ABCC_MRP_domain1	649..848	CDD:213217	124/203 (61%)
		ABC_membrane	988..1260	CDD:279056	117/278 (42%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	153/219 (70%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	658/1561 (42%)
		ABC_membrane	310..575	CDD:294371	111/265 (42%)
		ABCC_MRP_domain1	622..826	CDD:213217	124/203 (61%)
		ABC_membrane	976..1227	CDD:279056	108/251 (43%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	153/219 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	184	1.000	Domainoid score	I2038
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68364
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	LDO	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.790