DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and haf-3

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_506927.2	Gene:	haf-3 / 180056	WormBaseID:	WBGene00001813	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	654	Identity:	154/654 - (23%)
Similarity:	287/654 - (43%)	Gaps:	105/654 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   953 LKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSV-------------GI-FLSVATLVLNFVFQA 1003
            :|.||......:...|.::..::.|.:|. :|::             || ||.:::.:  |:|..
Worm    44 IKSKQAFRNVSVVETKRESYKLKNASWKD-LKAILSLAGPYKWRIMLGISFLGISSSI--FLFTP 105

  Fly  1004 FQIGSNLWLTQW---ANDQNVANDTGL------RDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQ 1059
            ..:|.  .:.:|   ..|:...||..|      ::..:.:.|.|..|...:| ..:..::..|..
Worm   106 RVLGK--LIDEWDETKQDKMDPNDKALLLARFFKENPIALAGVFMLGAIAIA-ARIYCMHTAGQL 167

  Fly  1060 AAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMD----SFMT------- 1113
            ....:...:...::|..:. |||...:|.:::..|.|..:|...:...:.    :.:|
Worm   168 VINDLRKSVFNSVLRQDMA-FFDKNKVGEIVSRLSTDALIVGYSVSMNLSDGARALITCFGSGGL 231

  Fly  1114 FIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTG 1178
            .::..||...||.:..|:.:........|    ||.|.     ||..|:|:.:...:  :|.::.
Worm   232 MVYTSLAMCKVIFVVVPVIVGTFAVFGKL----QRKYT-----LMMQEAVAGANQVA--TERLSS 285

  Fly  1179 ASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLE------MVGNLIIL-FASLFAV 1236
            ..|:|.            ...::.::..|...|...|...:.|      |.|:.... :.:|.::
Worm   286 VRTVRM------------LVAERKELAAYSDKINEIWQISKKEGLAKGFMFGSFQFTGYLALSSI 338

  Fly  1237 LGGQTN---PGLV--GLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQ 1296
            |...:|   .||:  |...|:.|....:...|..||.      ..:|.:|..|.:.:     |.:
Worm   339 LFYGSNLISQGLLTYGELSSFCLYAVLSAGSLSAMSG------FYLELMKGLGASSR-----LFE 392

  Fly  1297 DKNKPKNWPQEGRVEFQNFQ--VRYRE------GLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSL 1353
            .||:....|.||.|:..|.:  :|:..      ..|.:...:||::..|:...:||.:|:|||::
Worm   393 LKNREPRIPLEGGVQIGNVKDTIRFEHVAFGYADRDPLFHNISFDVPAGKITAVVGSSGSGKSTI 457

  Fly  1354 TLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRIN-----LDPFEIKTD 1413
            ...|.|:.:...|||.:||.|:..:.....|..:..:.|:|||||.:::.|     |:| |..||
Worm   458 ASLLLRLYDPTSGRILVDGTDLKDIDPSYWRRHIGTVGQEPVLFSTTIKENIIYGSLEP-ENVTD 521

  Fly  1414 DEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVD 1478
            .||..|.:.|:...|:.......:.::.|.|..||.||:|.:.:||||:.|..:|::||||:|:|
Worm   522 AEIVSAADQSNADEFISRFPIKYDTKVGEHGSTLSGGQKQRIAIARALVNKPNILIMDEATSALD 586

  Fly  1479 LETDDLIQ---KTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFY 1540
            ..::.|::   ..:....|: ||:.|||||:||..:|:::|:|:|.:.|..|..||:..|...|.
Worm   587 ASSEYLVRIALNKLLANSKQ-TVMIIAHRLSTIKHADQIVVVDRGSVAESGSYDELIAIPDGIFR 650

  Fly  1541 SMAK 1544
            .:.:
Worm   651 KLVE 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	154/654 (24%)
		ABC_membrane	338..601	CDD:279056
		ABCC_MRP_domain1	649..848	CDD:213217
		ABC_membrane	988..1260	CDD:279056	55/304 (18%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	75/235 (32%)
haf-3	NP_506927.2	MdlB	70..657	CDD:224055	149/628 (24%)
		ABC_membrane	96..366	CDD:279056	52/298 (17%)
		P-loop_NTPase	415..656	CDD:304359	77/242 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000