Protein Alignment MRP and Abcc1

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_032602.1
• Gene: Abcc1 / 17250
• MGIID: 102676
• Length: 1528
• Species: Mus musculus
• Alignment Length: 1576
• Identity: 778/1576 - (49%)
• Similarity: 1055/1576 - (66%)
• Gaps: 91/1576 - (5%)

  Fly    12 FCGS----TFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRN-IPWNK 71
            ||.:    ..|:...||:|::||||.||:.|.|.|.||.:.|:.....|:||... ||. |....
Mouse     6 FCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFFYLSRH-DRGYIQMTH 69

  Fly    72 LNVSKALVNLGLLVITALDLIMALVKKG-GDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYG 135
            ||.:|..:...|.:|...||..:..::. |....|:.   :..|.:...|.||....|.|.|:.|
Mouse    70 LNKTKTALGFFLWIICWADLFYSFWERSQGVLRAPVL---LVSPTLLGITMLLATFLIQLERRKG 131

  Fly   136 VQTTGCQFIFWF--LLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFT 198
            ||::|....||.  ||..|:|           .|.||:::   .::|...:.::..:|:::||..
Mouse   132 VQSSGIMLTFWLVALLCALAI-----------LRSKIISA---LKKDAHVDVFRDSTFYLYFTLV 182

  Fly   199 SIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQ 263
            .:.|:|:||:|..|..::.....|..||.|||||||||:.|...|.:.|||.|||..|||.|..:
Mouse   183 LVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKE 247

  Fly   264 DSCSEVMPIFAHHWNQNVRKNYKNKARV---------EPKAQFSNGNVTFE-------NPHGEKN 312
            |:..||:|:..::|.:...|:.|...|:         :||.. |..:|..|       :||.::.
Mouse   248 DTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGS-SQLDVNEEVEALIVKSPHKDRE 311

  Fly   313 GRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAV 377
                  .|:...:||:||..||...|.|...|.:.||.|::|.|||:||..::| |:|:|..|..
Mouse   312 ------PSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREA-PDWQGYFYTA 369

  Fly   378 LLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQR 442
            ||||.|..||..|.||||..|:.|:||:||::.|:|||||.|:|:.:|.||||||||||:|||||
Mouse   370 LLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQR 434

  Fly   443 FMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYK 507
            ||:|.||:|||||||||:.|||||||..||||||||:||||:::|:|.|:|.:.||||:..||.|
Mouse   435 FMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSK 499

  Fly   508 DERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLV 572
            |.|:|||||:|:|||||||||||.:|:.:|:.||.:|:..|:.:|||.|..:|.|.|.||||:|.
Mouse   500 DNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALS 564

  Fly   573 TFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPN 637
            |||.:|...|.|.|..:|..||:|||::::.||.||||:...|.:..||:.|:..||:.|||:|:
Mouse   565 TFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPD 629

  Fly   638 SVLHDSSKP---HPMSIENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGE 697
            |:...|.|.   :.::::|..|:|  |:..||..|...:.:|:|||:||.||.||||::.|.|.|
Mouse   630 SIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694

  Fly   698 MEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLT 762
            |:|:.|.|...|.:|||||||||||.::|:|||||.......|..|::||||..|::||.:||.|
Mouse   695 MDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRT 759

  Fly   763 EIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVL 827
            ||||||:|||||||||:||||||||::|:||.|||||||||||||||||:|:||.|:|..|:|:|
Mouse   760 EIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRIL 824

  Fly   828 VTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISS 892
            ||||:::|||||.|.|:..|:|||.|::.:|:...||||:|:..:   .|.|::        ::|
Mouse   825 VTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTY---ANAEQD--------LAS 878

  Fly   893 TADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSH-----DSVASAAS 952
            ..|.....|...|.::        :.:.||  |::   |..|:|......||     ...:|.|.
Mouse   879 EDDSVSGSGKESKPVE--------NGMLVT--DTV---GKHLQRHLSNSSSHSGDTSQQHSSIAE 930

  Fly   953 LKK--KQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQW 1015
            |:|  .:|...||:|.:|:|||.|:.:||.:|:|::|:|::..::.|........:.||.||:.|
Mouse   931 LQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLW 995

  Fly  1016 ANDQNVANDT-GLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCR 1079
            .:|..|.|.| ..|:..|.||||.|..||...:...:.|.:||..|::.:|.:||..::| |...
Mouse   996 TDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLR-SPMS 1059

  Fly  1080 FFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYY 1144
            ||:.||.|.|:|.||.::|.||..:|..:..||..:|.|:..:::|.|:|||...:|.|:..:|:
Mouse  1060 FFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYF 1124

  Fly  1145 FAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPS 1209
            |.||||||:||||.|||||||||:||||:||:.|.|.|||:...:|||.:||.|||:||...|||
Mouse  1125 FVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1189

  Fly  1210 VIANRWLAIRLEMVGNLIILFASLFAVLGGQT-NPGLVGLSVSYALQVTQTLNWLVRMSSDIETN 1273
            ::||||||:|||.|||.|:|||:||||:...: :.|||||||||:||:|..|||||||||::|||
Mouse  1190 IVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETN 1254

  Fly  1274 IVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGE 1338
            ||:|||:|||.||::||||:: |:...|..||..|||||:::.:||||.|||||:.::..|:|||
Mouse  1255 IVAVERLKEYSETEKEAPWQI-QETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGE 1318

  Fly  1339 KVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRI 1403
            |||||||||||||||||.||||.|:|.|.|.||||:||.:|||.||.::|||||||||||||||:
Mouse  1319 KVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRM 1383

  Fly  1404 NLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVL 1468
            |||||...:|:|:|.||||:|||.||.:|...||||.||||||||||||||||||||||||||:|
Mouse  1384 NLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKIL 1448

  Fly  1469 VLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLD 1533
            ||||||||||||||:|||.||||:|::|||||||||||||:|..:|||||||::.|..:|:|||.
Mouse  1449 VLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQ 1513

  Fly  1534 NPKSAFYSMAKDANLV 1549
            . :..||||||||.||
Mouse  1514 Q-RGIFYSMAKDAGLV 1528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	774/1571 (49%)
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	775/1572 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	876..895		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	909..929		4/19 (21%)