DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and Abcc4

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_038948894.1	Gene:	Abcc4 / 170924	RGDID:	620266	Length:	1382	Species:	Rattus norvegicus

Alignment Length:	1407	Identity:	502/1407 - (35%)
Similarity:	765/1407 - (54%)	Gaps:	174/1407 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289
            |...|:..||:.:.|.:.:...|::..|||.|::.:.|:|....:......:|::.|.:
  Rat    12 PLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLR------ 70

  Fly   290 RVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVL 354
                               .:|:.||   .|:...|.|.:...:|...:..|..:|....||..|
  Rat    71 -------------------AKKDARK---PSLTKAIVKCYWKSYLILGIFTLIEETTRVVQPIFL 113

  Fly   355 SLIISFVEAQDAEPE---WKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKA 416
            ..||.:.|..|::..   .....||.:|.:.......:...||:.:...|:|||.|:.:.|||||
  Rat   114 GKIIDYFEKYDSDDSAALHTAYGYAAVLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKA 178

  Fly   417 LRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQ-IGLALYFLWQQLGPSVLAGLA 480
            ||:|||...::|.|:||||::.|..:|.::|.:|:.:|:.||| ||:.: .||.::|.|.|||||
  Rat   179 LRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTI-LLWVEIGISCLAGLA 242

  Fly   481 VMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEI 545
            :::||:|:...|.....:.:.:...:.|.|::.||||::|::::|:||||.||...:.::|.|||
  Rat   243 ILVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEI 307

  Fly   546 ATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTI-LP 609
            :.:..::||.......:..|..::..|||.||||.  .|:::...|.|::.|:..::|.:|: .|
  Rat   308 SKILGSSYLRGMNMASFFIANKVILFVTFTTYVLL--GNKITASHVFVAMTLYGAVRLTVTLFFP 370

  Fly   610 MLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSWG---DEITLRNINIEV 671
            .....::|..|||.||..||..:||........|.....:.:::....|.   |..||:.::...
  Rat   371 SAIERVSEAVVSVRRIKNFLLLDELPERKAQEPSDGKAIVHVQDFTAFWDKALDTPTLQGLSFTA 435

  Fly   672 KKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYD 736
            :.|.|:|:||.||:||||::.|.|||:...:|:|:..|::|||.||.|:.:.|||.|||||:.|:
  Rat   436 RPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYE 500

  Fly   737 RKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAV 801
            ::||.|||.||||:.|:.:|..||||.||::|..||||||.|::||||||.|||:||||||||||
  Rat   501 KERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAV 565

  Fly   802 DAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFA 866
            ||.||||:|:..|..  .|..|..:||||.:.:|.....|.::|.||:.:.||:.:.:|:...|.
  Rat   566 DAEVGKHLFQLCICQ--TLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFG 628

  Fly   867 DFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGG 931
            ..    |::.|||.|.        |.....|.|           |..:.|:: |:.|
  Rat   629 SL----LKKENEEAEP--------SPVPGTPTL-----------RNRTFSEA-SIWS-------- 661

  Fly   932 GSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGI--FLSVAT 994
                :::.|....|.|..|...:..|..:.:    |....|.:.|..||:|. |.|.  |..:..
  Rat   662 ----QQSSRPSLKDGVPDAQDAENTQAAQPE----ESRSEGRIGFKAYKNYF-SAGASWFFIIFL 717

  Fly   995 LVLNFVFQAFQIGSNLWLTQWANDQNVAND--------TGLRDM--YLGVYGA-------FGFGQ 1042
            ::||.:.|.|.:..:.||:.|||.|...||        ||..|:  |||:|..       ||..:
  Rat   718 VLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGTLDLSWYLGIYTGLTAVTVLFGIAR 782

  Fly  1043 GVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPI--------------------- 1086
            .:|.::.:|       .|::|:||.:...|::..|. |||..||
  Rat   783 SLLVFYVLV-------NASQTLHNRMFESILKAPVL-FFDRNPIELTQLEVFRVVDGALDSHRHL 839

  Fly  1087 ------------------------------------GRLLNSFSGDMDVVDEELPATMDSFMTFI 1115
                                                ||:||.||.|:..:|:.||.|...|:..:
  Rat   840 SHPHPWPQNGSLQASVTSVTGSDVIRFPEVLLLALPGRILNRFSKDIGHMDDLLPLTFLDFIQTL 904

  Fly  1116 FMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGAS 1180
            .:|::.|.|.:...|..|..:||::.::...:|:::.|||.:.||||.:|||::||.|.::.|..
  Rat   905 LLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLW 969

  Fly  1181 TIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLE---MVGNLIILFASLFAVLGGQTN 1242
            |||||...:|..|..||..|.:....:..:..:||.|:||:   .|..:::.|.||  ||....:
  Rat   970 TIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSL--VLAKTLD 1032

  Fly  1243 PGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQE 1307
            .|.|||::||:|.:.....|.||.|:::|..::||||:.||.:.::|||||..  |..|..||.|
  Rat  1033 AGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECR--KRPPPGWPHE 1095

  Fly  1308 GRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDG 1372
            |.:.|.|....|.....|||:.::..|:..||||||||||||||||..||||:.|.. |:|.||.
  Rat  1096 GVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPE-GKIWIDK 1159

  Fly  1373 VDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLN 1437
            :....:|||.||.:::||||:||||:|::|.|||||...:|:|:|||||...||..::.|...::
  Rat  1160 ILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMD 1224

  Fly  1438 HEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIA 1502
            .|:||.|.|.|||||||||||||:|:|.::|::|||||.||..||:|||:.||.:|.:|||||||
  Rat  1225 TELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIA 1289

  Fly  1503 HRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544
            ||||||:||||::|||.|::.|:..|..||.||:|.||.|.:
  Rat  1290 HRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKMVQ 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	502/1407 (36%)
		ABC_membrane	338..601	CDD:279056	90/266 (34%)
		ABCC_MRP_domain1	649..848	CDD:213217	98/201 (49%)
		ABC_membrane	988..1260	CDD:279056	97/350 (28%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	121/219 (55%)
Abcc4	XP_038948894.1	MRP_assoc_pro	6..1334	CDD:188098	502/1407 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660