DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and Abcc2

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_038834.2 Gene:Abcc2 / 12780 MGIID:1352447 Length:1543 Species:Mus musculus


Alignment Length:1599 Identity:720/1599 - (45%)
Similarity:1024/1599 - (64%) Gaps:123/1599 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 MDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLN 73
            ||.||.|||||.: ...:.:.|...|||||.|||.|..|.|....:..|.:..|..:.....|..
Mouse     1 MDEFCNSTFWNLS-LLKSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLYRIYRSRTKRFAITKFY 64

  Fly    74 VSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQT 138
            ::|.:..:.||::.|:||.:||.:..|.:.:|  .:....||:...|:||:.: |...|:..:|.
Mouse    65 LAKQVFVVCLLILAAIDLSLALTEDTGQATIP--PVKYTNPILYLCTWLLVLV-IQHCRQCCIQK 126

  Fly   139 TGCQF-IFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIML 202
            ..... :||.|..:..|.:.:|.:|       .|.....|...:|      ..||:.:.|..::|
Mouse   127 NSWFLSMFWILSLLCGIFQFQTLIR-------ALLQDSKSNMTYS------CLFFVSYGFQIVIL 178

  Fly   203 ILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCS 267
            ||:.|::        .......|..:|||||.:|:.|:|...||||::||..:|:||:.......
Mouse   179 ILSAFSE--------SSDSTHAPSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAK 235

  Fly   268 EVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNG------------------- 313
            .:...|.....::::|..:...|...|:|        ::|.|..:|                   
Mouse   236 SLTSKFKTIMTKDLQKARQALQRRLKKSQ--------QSPEGTSHGLTKKQSQSQDVLVLEDSKK 292

  Fly   314 -RKKGMAS-------IMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEW 370
             :||..|:       ::..::|:|..|.|...::||..|.|.|..||:|..:|.||:..|:.| |
Mouse   293 KKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFLNPQLLKFLIGFVKDPDSYP-W 356

  Fly   371 KGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNL 435
            .|.:||:|:|.:...|:|.|..||...|::|:.:||.:|.::|:|||.:||..:::.|:||.|||
Mouse   357 VGYIYAILMFSVTLIQSFFLQCYFQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNL 421

  Fly   436 MAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQ 500
            |:||:|:.|::|.|::::||:.|||.|:::|||::||||:|||:.:|::|:|||||:|::|:..|
Mouse   422 MSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQ 486

  Fly   501 IRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA 565
            ::.||.||:|:|:|||:|||||:||.:||||||::||..||.||:..|...:.|.....|:....
Mouse   487 VQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLT 551

  Fly   566 PFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLN 630
            |.|||::||:.|||....|.|:.||...||.||::::.||.:|||:...:.:..|||:|:.::|.
Mouse   552 PTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYLG 616

  Fly   631 SEELDPNSVLHDSSKPHPMSIENGEFSWGD--EITLRNINIEVKKGSLVALVGTVGSGKSSVVQA 693
            |::||.:::.|.......:......|:|..  |.|::::|:::|.|.|||:||||||||||::.|
Mouse   617 SDDLDLSAIRHVCHFDKAVQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISA 681

  Fly   694 FLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSA 758
            .|||||.:.|.:...|.:|||||||||||.|::||||||..||.|:|.:||:||||..|:::|..
Mouse   682 MLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPG 746

  Fly   759 GDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARK 823
            ||:.||||||||||||||.|:|||||.|.|||:|:|||||||||.|||||||.:|:||.|:|:.|
Mouse   747 GDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGK 811

  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFA----DFIIQHLQEG-----NEE 879
            :|:|||||:.||||||.|.|:..|.|.|.|::..|:..||.||    .|:.....||     |:.
Mouse   812 TRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDS 876

  Fly   880 EEELNQIKRQISSTADVPELLGTVEK------AIKLARTESLSDSISVTSADSLMGGGGSLRRRT 938
            |||....           .|:.|||:      ::.:.|..||..::|.:|.      .||  ||.
Mouse   877 EEEDGDC-----------GLIPTVEEIPDDAASLTMRRENSLRRTLSRSSR------SGS--RRG 922

  Fly   939 KRQDSHDSVASAASLKKKQE-VEG-KLIETEKSQTGGVEFAVYKHYIKSVG---IFLSVATLVLN 998
            |...|...:.|..:|.||:| |:| |||:.|..:||.|:|::|..|:::||   :...|...|||
Mouse   923 KSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLN 987

  Fly   999 FVFQAFQIGSNLWLTQWANDQNVANDT----GLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQ 1059
            :|  || ||:||||:.|.:|....|.|    ..|||.:||:||.|..||:....:.:........
Mouse   988 YV--AF-IGTNLWLSAWTSDSEKQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYACRN 1049

  Fly  1060 AAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVV 1124
            |:||:|.:||..|:|..: .|||.||.||::|.|:||:..||:.||.|:.|::...|.:::|:|:
Mouse  1050 ASKTLHRQLLTNILRAPM-SFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVM 1113

  Fly  1125 ISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGD 1189
            |.::||||:.:|:|::.||...|.|||||||||.||:||::|||||||||||:|...|||:....
Mouse  1114 ICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQ 1178

  Fly  1190 RFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAV-----LGGQTNPGLVGLS 1249
            ||:..|:.::|.||.|.:..:.:|||||||||:|||||:..::|..|     |.|.|    ||..
Mouse  1179 RFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDT----VGFV 1239

  Fly  1250 VSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQN 1314
            :|.||.:||||||||||:|::|||||:||||.||.....||||  ..||..|.:||::|.::|.|
Mouse  1240 LSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPW--VTDKKPPADWPKKGEIQFNN 1302

  Fly  1315 FQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMG 1379
            :|||||..|||||:|::.||:..||||:||||||||||||..||||:|:|||:|.|||:||||:|
Mouse  1303 YQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIG 1367

  Fly  1380 LHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGG 1444
            ||.||.|||||||||:||||:||:|||||...:|:|||:||||:||||||..|..||.||:.|||
Mouse  1368 LHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGG 1432

  Fly  1445 ENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTIL 1509
            :|||:|||||:||.||:|||:|:|||||||||||||||.|||.|||.||.:|||:||||||:||:
Mouse  1433 DNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIM 1497

  Fly  1510 DSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANL 1548
            ||||::|||.|:|:|:.||.|||.| ...||.|||:|.:
Mouse  1498 DSDKIMVLDSGKIVEYGSPEELLSN-MGPFYLMAKEAGI 1535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 716/1592 (45%)
ABC_membrane 338..601 CDD:279056 122/262 (47%)
ABCC_MRP_domain1 649..848 CDD:213217 121/200 (61%)
ABC_membrane 988..1260 CDD:279056 126/280 (45%)
ABCC_MRP_domain2 1308..1528 CDD:213211 155/219 (71%)
Abcc2NP_038834.2 MRP_assoc_pro 10..1535 CDD:188098 713/1588 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..285 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..927 10/31 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 221 1.000 Domainoid score I2597
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0000087
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X177
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.890

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