Protein Alignment MRP and Abcc2

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_038834.2
• Gene: Abcc2 / 12780
• MGIID: 1352447
• Length: 1543
• Species: Mus musculus
• Alignment Length: 1599
• Identity: 720/1599 - (45%)
• Similarity: 1024/1599 - (64%)
• Gaps: 123/1599 - (7%)

  Fly     9 MDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLN 73
            ||.||.|||||.: ...:.:.|...|||||.|||.|..|.|....:..|.:..|..:.....|..
Mouse     1 MDEFCNSTFWNLS-LLKSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLYRIYRSRTKRFAITKFY 64

  Fly    74 VSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQT 138
            ::|.:..:.||::.|:||.:||.:..|.:.:|  .:....||:...|:||:.: |...|:..:|.
Mouse    65 LAKQVFVVCLLILAAIDLSLALTEDTGQATIP--PVKYTNPILYLCTWLLVLV-IQHCRQCCIQK 126

  Fly   139 TGCQF-IFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIML 202
            ..... :||.|..:..|.:.:|.:|       .|.....|...:|      ..||:.:.|..::|
Mouse   127 NSWFLSMFWILSLLCGIFQFQTLIR-------ALLQDSKSNMTYS------CLFFVSYGFQIVIL 178

  Fly   203 ILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCS 267
            ||:.|::        .......|..:|||||.:|:.|:|...||||::||..:|:||:.......
Mouse   179 ILSAFSE--------SSDSTHAPSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAK 235

  Fly   268 EVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNG------------------- 313
            .:...|.....::::|..:...|...|:|        ::|.|..:|
Mouse   236 SLTSKFKTIMTKDLQKARQALQRRLKKSQ--------QSPEGTSHGLTKKQSQSQDVLVLEDSKK 292

  Fly   314 -RKKGMAS-------IMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEW 370
             :||..|:       ::..::|:|..|.|...::||..|.|.|..||:|..:|.||:..|:.| |
Mouse   293 KKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFLNPQLLKFLIGFVKDPDSYP-W 356

  Fly   371 KGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNL 435
            .|.:||:|:|.:...|:|.|..||...|::|:.:||.:|.::|:|||.:||..:::.|:||.|||
Mouse   357 VGYIYAILMFSVTLIQSFFLQCYFQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNL 421

  Fly   436 MAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQ 500
            |:||:|:.|::|.|::::||:.|||.|:::|||::||||:|||:.:|::|:|||||:|::|:..|
Mouse   422 MSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQ 486

  Fly   501 IRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA 565
            ::.||.||:|:|:|||:|||||:||.:||||||::||..||.||:..|...:.|.....|:....
Mouse   487 VQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLT 551

  Fly   566 PFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLN 630
            |.|||::||:.|||....|.|:.||...||.||::::.||.:|||:...:.:..|||:|:.::|.
Mouse   552 PTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYLG 616

  Fly   631 SEELDPNSVLHDSSKPHPMSIENGEFSWGD--EITLRNINIEVKKGSLVALVGTVGSGKSSVVQA 693
            |::||.:::.|.......:......|:|..  |.|::::|:::|.|.|||:||||||||||::.|
Mouse   617 SDDLDLSAIRHVCHFDKAVQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISA 681

  Fly   694 FLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSA 758
            .|||||.:.|.:...|.:|||||||||||.|::||||||..||.|:|.:||:||||..|:::|..
Mouse   682 MLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPG 746

  Fly   759 GDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARK 823
            ||:.||||||||||||||.|:|||||.|.|||:|:|||||||||.|||||||.:|:||.|:|:.|
Mouse   747 GDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGK 811

  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFA----DFIIQHLQEG-----NEE 879
            :|:|||||:.||||||.|.|:..|.|.|.|::..|:..||.||    .|:.....||     |:.
Mouse   812 TRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDS 876

  Fly   880 EEELNQIKRQISSTADVPELLGTVEK------AIKLARTESLSDSISVTSADSLMGGGGSLRRRT 938
            |||....           .|:.|||:      ::.:.|..||..::|.:|.      .||  ||.
Mouse   877 EEEDGDC-----------GLIPTVEEIPDDAASLTMRRENSLRRTLSRSSR------SGS--RRG 922

  Fly   939 KRQDSHDSVASAASLKKKQE-VEG-KLIETEKSQTGGVEFAVYKHYIKSVG---IFLSVATLVLN 998
            |...|...:.|..:|.||:| |:| |||:.|..:||.|:|::|..|:::||   :...|...|||
Mouse   923 KSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLN 987

  Fly   999 FVFQAFQIGSNLWLTQWANDQNVANDT----GLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQ 1059
            :|  || ||:||||:.|.:|....|.|    ..|||.:||:||.|..||:....:.:........
Mouse   988 YV--AF-IGTNLWLSAWTSDSEKQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYACRN 1049

  Fly  1060 AAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVV 1124
            |:||:|.:||..|:|..: .|||.||.||::|.|:||:..||:.||.|:.|::...|.:::|:|:
Mouse  1050 ASKTLHRQLLTNILRAPM-SFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVM 1113

  Fly  1125 ISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGD 1189
            |.::||||:.:|:|::.||...|.|||||||||.||:||::|||||||||||:|...|||:....
Mouse  1114 ICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQ 1178

  Fly  1190 RFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAV-----LGGQTNPGLVGLS 1249
            ||:..|:.::|.||.|.:..:.:|||||||||:|||||:..::|..|     |.|.|    ||..
Mouse  1179 RFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDT----VGFV 1239

  Fly  1250 VSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQN 1314
            :|.||.:||||||||||:|::|||||:||||.||.....||||  ..||..|.:||::|.::|.|
Mouse  1240 LSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPW--VTDKKPPADWPKKGEIQFNN 1302

  Fly  1315 FQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMG 1379
            :|||||..|||||:|::.||:..||||:||||||||||||..||||:|:|||:|.|||:||||:|
Mouse  1303 YQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIG 1367

  Fly  1380 LHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGG 1444
            ||.||.|||||||||:||||:||:|||||...:|:|||:||||:||||||..|..||.||:.|||
Mouse  1368 LHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGG 1432

  Fly  1445 ENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTIL 1509
            :|||:|||||:||.||:|||:|:|||||||||||||||.|||.|||.||.:|||:||||||:||:
Mouse  1433 DNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIM 1497

  Fly  1510 DSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANL 1548
            ||||::|||.|:|:|:.||.|||.| ...||.|||:|.:
Mouse  1498 DSDKIMVLDSGKIVEYGSPEELLSN-MGPFYLMAKEAGI 1535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	716/1592 (45%)
Abcc2	NP_038834.2	MRP_assoc_pro	10..1535	CDD:188098	713/1588 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..285		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	903..927		10/31 (32%)