DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and Cftr

DIOPT Version :10

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_312930.5 Gene:Cftr / 1273896 VectorBaseID:AGAMI1_011650 Length:1450 Species:Anopheles gambiae


Alignment Length:1467 Identity:464/1467 - (31%)
Similarity:721/1467 - (49%) Gaps:242/1467 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289
            |...|..||::.:.|...:..:|.|..|.:.||......|...::.......|.:.|     ::|
Mosquito    12 PRKGAFCLSQLFFGWLLPLFYRGSRRGLGKDDLTKCLKADRSEDLGDELEEQWEKEV-----SQA 71

  Fly   290 RV---EPK--------------------------------------AQFSN-------------- 299
            |:   |||                                      .||..              
Mosquito    72 RIASREPKLRNALFRTFYKQSLFDGFLIFLFVLIKTILPVVLAQLLVQFQEPTNSTHVAVVNMNN 136

  Fly   300 ------------------------GNVTFEN---------------------PHGEKNGRKKGMA 319
                                    .|:.|:.                     |.....|.|..:|
Mosquito   137 DVFSTVPPMAMPLMMLPDTTQSHLENLVFDETAMINKRRRKRRIRIEDDKPAPGNSIGGSKPNVA 201

  Fly   320 --------SIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEW-KGILY 375
                    :|:|.:.:.||.           .|....|...|:..:..|:.....:..| .|:| 
Mosquito   202 QEAEAMETTILPDLSEQFGA-----------DDPSATANSTVVDDLSDFLHHAWNDAFWLSGLL- 254

  Fly   376 AVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDA 440
             |||.:|..   |.......|..:||.|:|.|..:.||||.||:|.....::..|.::||::.|.
Mosquito   255 -VLLTLLGC---FCCHHSDLRERLVGARMRIACCSLIYRKTLRMSRKAAGQTPAGYMINLLSNDV 315

  Fly   441 QRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMII-LIPVNGVIASRIKTYQIRQM 504
            .|......|::.:|..|.|.....|.:|:::..:.:.|:..::: .|||...::......::|..
Mosquito   316 SRLDYGFIYVHYVWVLPFQACFTCYLIWRRVQWAAIVGVVGLLVKTIPVQTGLSRLSSIIRMRVA 380

  Fly   505 KYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV 569
            |..|:||.:|||::.||:|:|:||||..|.|.|...|.||:..:|..:|:..             
Mosquito   381 KKTDQRVGIMNELIQGIQVIKMYAWEKPFHKVVSLARKKEVRQIRWASYIRG------------- 432

  Fly   570 SLVTFATYVLTS-------------EANQLSVEKVLVSIALFDLMKLPLTILPMLSVDI-AETQV 620
              :..:|.|.|.             |...::.:.|......|::::|...|...|:|.: ||..|
Mosquito   433 --IYLSTMVFTERSTLFLAIACCVIEGRAITADIVFPMAQFFNILQLTAAIFYPLAVSLGAEALV 495

  Fly   621 SVNRINKFLNSEELD--PNSV------------LH----DSSKPHPMSIENGEFSWGD--EITLR 665
            |::||.:||..:|.|  |.|.            ||    ..:|| .:.::|...||.:  :.||:
Mosquito   496 SIDRIQEFLALQEHDATPPSASATGGLKRNLNDLHLLAEHDNKP-AIELQNVTASWEETTDKTLK 559

  Fly   666 NINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNIL 730
            :|:::::.|.|:|::|.||:||||::|..|||:....|.....|.::|..|:.|:...|||:|||
Mosquito   560 DISVKIEPGRLLAVIGPVGAGKSSLLQMLLGELPIQNGTATINGDVSYGSQEPWLFTGTVRNNIL 624

  Fly   731 FGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLD 795
            ||..|||.||..|:..|||..|...|..||.|.:||:|.:|||||:.|:|||||||::|.:||||
Mosquito   625 FGLPYDRHRYQAVVRHCALTTDFQQLPDGDKTVVGERGTSLSGGQRARVSLARAVYNNASIYLLD 689

  Fly   796 DPLSAVDAHVGKHIFEEVIGPKGILARK---SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQ 857
            |||||||||||||:|:|||||:|.||:|   :||||||.|.||.:.|.|.:|:.|:|...||:.:
Mosquito   690 DPLSAVDAHVGKHLFDEVIGPRGYLAQKQKATRVLVTHQVHFLKEADWIVIIEGGKIVTQGTYTE 754

  Fly   858 LVKNKGAFADFIIQ-HLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLS--DSI 919
            |...|..|...:.. ..::|..::..|         .||:||              :.:.  |.:
Mosquito   755 LANGKVDFGKLLKSGEPEKGGADDSVL---------AADIPE--------------DEIPFIDGV 796

  Fly   920 SVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIK 984
            ::.....|.|...|||..|.     .|.||:.:....::|      .|....|.:.:.::..|..
Mosquito   797 TLDGYKLLKGSTVSLRGVTP-----SSCASSVADNLGRQV------AEDQAEGTISWRIWATYFL 850

  Fly   985 SVG-IFLSVATLVLNFVFQAFQIGSNLWLTQWANDQ--NVAND---TGLRDMYLGVYGAFGFGQG 1043
            |.| :.:.:.|.::....||...||:.::|.|...:  .:.|:   |..:..:|..||....|..
Mosquito   851 SGGNVLMLLFTFLMLLFSQAIVSGSDYFVTYWTRQEELRLVNERAVTTTKVDFLYTYGVIIIGVV 915

  Fly  1044 VLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATM 1108
            |...|...:.:....:|::.:|:.:.|.::...: ||||..|.||:||.||.||..:||.||..|
Mosquito   916 VFTIFRGYLFFNICMKASRNLHDRMFARMLTAPM-RFFDTNPSGRILNRFSKDMGAIDELLPKAM 979

  Fly  1109 DSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFS 1173
            ...:..:.::...:.:|::..|:.|..::....||..|.:.|:...:.:.|||.::|||::||.|
Mosquito   980 IEAIQILLVMTGILTMITIVNPLLLLPLLGAVLLYAIALKLYLRPIQDMKRLEGITRSPVFSHLS 1044

  Fly  1174 ETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASL-FAVL 1237
            .|::|.|||||..|.::..||.|...:.:......::.:|..|.:.|:.:....:...:. |.||
Mosquito  1045 ATLSGLSTIRASGVQEKIREEFDDLQNVHSAVWQLTMSSNAALGLWLDCISTAFVACVTFSFIVL 1109

  Fly  1238 GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPK 1302
            ...|....|||::|.||.:|..:.:.:|.:::....:.:|||:.:|.|...|.    :..|..|.
Mosquito  1110 HQDTYSANVGLAISQALILTGMVQYGIRQTTESIQQMTAVERVVQYTEIASET----DPPKVPPG 1170

  Fly  1303 NWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRI--IEAAG 1365
            :||.:|:::|.|..:.|.:....||:.:...|:...|||||||||||||||..||||:  ||   
Mosquito  1171 DWPWKGQIQFHNMSLCYEQDAPPVLKNLELVIEPTWKVGIVGRTGAGKSSLIGALFRLARIE--- 1232

  Fly  1366 GRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVK 1430
            |||.|||:|...:.|..|||:::||||||||||.::|.|||||.:..||.:|:|:....|:|.: 
Mosquito  1233 GRIMIDGIDTGVISLEALRSKISIIPQDPVLFSATIRYNLDPFSLYDDDMLWRAIGEVELRSAI- 1296

  Fly  1431 SLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKE 1495
               :||:..:.|||.|.|||||||:|||||:||..|:||||||||.||.:||.|||||||.:||.
Mosquito  1297 ---SGLDFMVTEGGTNFSVGQRQLICLARAILRNNKILVLDEATANVDPQTDALIQKTIREKFKH 1358

  Fly  1496 CTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELL 1532
            |||||:||||:|::|||:::|:|.|:..||.:|..||
Mosquito  1359 CTVLTVAHRLHTVMDSDRILVMDAGEAREFDTPHILL 1395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 464/1467 (32%)
CftrXP_312930.5 MRP_assoc_pro <276..1404 CDD:188098 420/1182 (36%)

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