Protein Alignment MRP and Cftr

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_066388.1
• Gene: Cftr / 12638
• MGIID: 88388
• Length: 1476
• Species: Mus musculus
• Alignment Length: 1492
• Identity: 386/1492 - (25%)
• Similarity: 678/1492 - (45%)
• Gaps: 240/1492 - (16%)

  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289
            |...|||:|::.:.|...:..||||:.||..|::.....||...:.......|::.
Mouse     5 PLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDRE--------- 60

  Fly   290 RVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVL 354
                       ..:.:||            .::..:.:.|...|||..::....:.....||.:|
Mouse    61 -----------QASKKNP------------QLIHALRRCFFWRFLFYGILLYLGEVTKAVQPVLL 102

  Fly   355 SLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRI 419
            ..||:..:.::.......|...:.|.:|...:|.:|......:..:|:::|||:.:.||:|.|::
Mouse   103 GRIIASYDPENKVERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKL 167

  Fly   420 SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMII 484
            |:....:.::|::|:|::.:..:|.|.....:.||.||||:.|.:..||..|..|...||.::||
Mouse   168 SSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLII 232

  Fly   485 LIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLR 549
            |:....::...:..|:.::....:||:.:.:|::..|..:|.|.||.:.||.:.::|:.|:...|
Mouse   233 LVIFQAILGKMMVKYRDQRAAKINERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTR 297

  Fly   550 STAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVD 614
            ..||:...||..:..:.|.|..::...|.:   .|.:.:.|:..:|:...::::.:|.....:|.
Mouse   298 KAAYMRFFTSSAFFFSGFFVVFLSVLPYTV---INGIVLRKIFTTISFCIVLRMSVTRQFPTAVQ 359

  Fly   615 I-AETQVSVNRINKFLNSEE---LDPNSVL-------------------------HDSSKPHPMS 650
            | .::...:.:|..||..:|   |:.|.:.                         .:..:.|...
Mouse   360 IWYDSFGMIRKIQDFLQKQEYKVLEYNLMTTGIIMENVTAFWEEGFGELLEKVQQSNGDRKHSSD 424

  Fly   651 IENGEFSW----GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKL 711
            ..|..||.    |:.: |:|||:.::||.::|:.|:.||||:|::...|||:|...|::...|::
Mouse   425 ENNVSFSHLCLVGNPV-LKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRV 488

  Fly   712 AYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQK 776
            ::..|.:||...|:::||:||.:||..||..|:.||.|:.||...:..|.|.:||.|:.|||||:
Mouse   489 SFCSQFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQR 553

  Fly   777 QRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSI 841
            .|||||||||.||||||||.|...:|....:.:||..:..  ::|.|:|:|||..:..|.:.|.|
Mouse   554 ARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCK--LMANKTRILVTSKMEHLRKADKI 616

  Fly   842 YVIKMGEISESGTFDQLVKNKGAFADFIIQH---------------------------------- 872
            .::..|.....|||.:|...:..|:..::.:
Mouse   617 LILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDSSAPWSKP 681

  Fly   873 ----LQEGNEEEEELNQIKRQISSTADVPELLGT-----------VEKAIKLA------------ 910
                .|.|...|:..|.|....||...:..:..|           .||.:.|.
Mouse   682 KQSFRQTGEVGEKRKNSILNSFSSVRKISIVQKTPLCIDGESDDLQEKRLSLVPDSEQGEAALPR 746

  Fly   911 -------------RTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGK 962
                         |.:|:.|.::.|.     ..|.|..:||:......|:....||.:......:
Mouse   747 SNMIATGPTFPGRRRQSVLDLMTFTP-----NSGSSNLQRTRTSIRKISLVPQISLNEVDVYSRR 806

  Fly   963 LIE------TEKSQTGGVE----------------------FAVYKHYIKSVGIFLSVATLVLNF 999
            |.:      ||:.....::                      |.::|      |:.|.:...||.|
Mouse   807 LSQDSTLNITEEINEEDLKECFLDDVIKIPPVTTWNTYLRYFTLHK------GLLLVLIWCVLVF 865

  Fly  1000 VFQAFQIGSNLWLTQWANDQNVANDTGLR---DMYLGVYGAFGFGQGVLAYFAVVIVYLGG---- 1057
            :.:.......|||.: .|..|..|: |.:   ..|:.:..:..|       :.:..:|:|.
Mouse   866 LVEVAASLFVLWLLK-NNPVNSGNN-GTKISNSSYVVIITSTSF-------YYIFYIYVGVADTL 921

  Fly  1058 ---------------FQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPAT 1107
                           ..|:|.:|.::|..|:...:.....: ..|.:||.||.|:.::|:.||.|
Mouse   922 LALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTISKL-KAGGILNRFSKDIAILDDFLPLT 985

  Fly  1108 MDSFMTFIFMVLATIVVISLSTP-IFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSH 1171
            :..|:..:|:|:..|:|:|...| ||||. ||...::...:.:::.|::||.:|||..||||::|
Mouse   986 IFDFIQLVFIVIGAIIVVSALQPYIFLAT-VPGLVVFILLRAYFLHTAQQLKQLESEGRSPIFTH 1049

  Fly  1172 FSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIAN-RWLAIRLEMVGNLIILFASLFA 1235
            ...::.|..|:||:. ...:.|....|........:...:|. ||..:|::|:..|..:..:..:
Mouse  1050 LVTSLKGLWTLRAFR-RQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFIS 1113

  Fly  1236 VLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERI----------KEYGETKQEA 1290
            :|......|..|:.::.|:.:..||.|.|..|.|.::.:.||.|:          ..|.:..:|.
Mouse  1114 ILTTGEGEGTAGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESMYTQIIKEL 1178

  Fly  1291 PWELEQD----KN----KPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTG 1347
            |.|...|    ||    |...||..|.:..::..|:|.:..:.||..:||:|..|::||::||||
Mouse  1179 PREGSSDVLVIKNEHVKKSDIWPSGGEMVVKDLTVKYMDDGNAVLENISFSISPGQRVGLLGRTG 1243

  Fly  1348 AGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKT 1412
            :|||:|..|..|::...|. |.||||...|:.|...|....:|.|...:|||:.|.||||.....
Mouse  1244 SGKSTLLSAFLRMLNIKGD-IEIDGVSWNSVTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWK 1307

  Fly  1413 DDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAV 1477
            |:||||..:...|||.::.....||..:.:||..||.|.:||:||||::|.|.|:::|||.:|.:
Mouse  1308 DEEIWKVADEVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHL 1372

  Fly  1478 DLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            |..|..:|::.::..|..|||:...||:..:||..:.:|:::..:.::.|...|| :.||.|
Mouse  1373 DPITYQVIRRVLKQAFAGCTVILCEHRIEAMLDCQRFLVIEESNVWQYDSLQALL-SEKSIF 1433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	386/1492 (26%)
Cftr	NP_066388.1	CFTR_protein	1..1464	CDD:273530	386/1492 (26%)
		Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569	654..826		25/176 (14%)
		Interaction with GORASP2. /evidence=ECO:0000250|UniProtKB:P13569	1382..1476		15/53 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1446..1476
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569	1474..1476