DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and Abcc5

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_446376.1 Gene:Abcc5 / 116721 RGDID:70913 Length:1436 Species:Rattus norvegicus


Alignment Length:1446 Identity:494/1446 - (34%)
Similarity:748/1446 - (51%) Gaps:226/1446 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 TKYQRGENEIPELSASFLSRITYQWFDKMA-LKGYRNPLEEKDLWDLRPQDS----CSEVMPIFA 274
            ||:|.     |..:|...|.:|:.|...:| :...:..|..:|:|.|...:|    |..:..::.
  Rat    95 TKHQH-----PVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYESSDVNCRRLERLWQ 154

  Fly   275 HHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALM 339
            ...|:           |.|.|                       ||:...::.......:...:.
  Rat   155 EELNE-----------VGPDA-----------------------ASLRRVVWIFCRTRLILSIVC 185

  Fly   340 KLFTDTLTFAQPQ-VLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLR 403
            .:.|....|:.|. |:..::.:.:|.::..:: .:|..:.|.:....:::.|...:...:..|:|
  Rat   186 LMITQLAGFSGPAFVVKHLLEYTQATESNLQY-SLLLVLGLLLTEVVRSWSLALTWALNYRTGVR 249

  Fly   404 IRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLW 468
            :|.|::...::|.|::.|.  ||.::||::|:.:.|.||..|.....:::...|:...|.:.:..
  Rat   250 LRGAVLTMAFKKILKLKNI--KEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNV 312

  Fly   469 QQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQ-MKYKDERVKLMNEVLSGIKVLKLYAWEPS 532
            ..|||:...|.||.|:..|.. :..||:..|..|: :...|:||:.|||||:.||.:|:|||..:
  Rat   313 IILGPTGFLGSAVFILFYPAM-MFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKA 376

  Fly   533 FEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV---SLVTFATYVLTSEANQLSVEKVLVS 594
            |.:.|..||::|...|....|..   |.....||.:|   |:|||:.::  :....|:..:....
  Rat   377 FSQCVQKIREEERRILEKAGYFQ---SITVGVAPIVVVIASVVTFSVHM--TLGFDLTAAQAFTV 436

  Fly   595 IALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPH-PMSIENGEFSW 658
            :.:|:.|...|.:.|.....::|..|:|:|.......||:  :.:.:..:.|| .:.::|...:|
  Rat   437 VTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV--HMIKNKPASPHIKIEMKNATLAW 499

  Fly   659 ----------------------------------------------------------------G 659
                                                                            |
  Rat   500 DSSHSSTQSSPKLTPKVKKDKRAPKGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEG 564

  Fly   660 DEI---------TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVP 715
            .:|         ||.||::|:::|.||.:.|:|||||:|::.|.||:|..|.|.:...|..|||.
  Rat   565 KQIHAGSMRLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVA 629

  Fly   716 QQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRIS 780
            |||||.|||:|||||||:.:|.:|||.|:::|.||.|:.||...|||||||:|.||||||:||||
  Rat   630 QQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRIS 694

  Fly   781 LARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK 845
            ||||:|||..:|:|||||||:|||||.|||...|..:  |..|:.:.|||.:.:|...|.:..:|
  Rat   695 LARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKR--LKSKTVLFVTHQLQYLVDCDEVIFMK 757

  Fly   846 MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLA 910
            .|.|:|.||.::|:...|.:|. |..:|..|.....|:|. |::.|.:                 
  Rat   758 EGCITERGTHEELMNLNGDYAT-IFNNLLLGETPPVEINS-KKEASGS----------------- 803

  Fly   911 RTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEV---EGKLIETEKSQTG 972
                                          |.|.|......|:||::.|   ||:|::.|:...|
  Rat   804 ------------------------------QKSQDKGPKPGSVKKEKAVKSEEGQLVQVEEKGQG 838

  Fly   973 GVEFAVYKHYIKSVG---IFLSVATL-VLNFVFQAFQIGSNLWLTQWANDQNVANDT-------- 1025
            .|.::||..||::.|   .||.:..| :||....||   |..||:.|.. |...|.|        
  Rat   839 SVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAF---STWWLSYWIK-QGSGNSTVFEGNRSS 899

  Fly  1026 ---GLRD-----MYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFD 1082
               .:||     .|..:|........:|.....|:...|..:|:..:|:||...|:| |..:|||
  Rat   900 VSDSMRDNPFLQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILR-SPMKFFD 963

  Fly  1083 ITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLY---Y 1144
            .||.||:||.||.|||.||..||...:.|:..:.:|...:.:|:...|.||..:.|:..|:   :
  Rat   964 TTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSVLH 1028

  Fly  1145 FAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPS 1209
            ...|..:   |:|.||:::::||..||.:.::.|.:||.|||....|:......:|.||...:..
  Rat  1029 IVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLF 1090

  Fly  1210 VIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETN 1273
            ..|.||||:||:::...:|....|..|| .||......||::|||:|:|....:.||::|:.|..
  Rat  1091 TCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEAR 1155

  Fly  1274 IVSVERIKEYGET-KQEAPWELEQDKNK--PKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQ 1335
            ..|||||..|.:| ..|||..:   |||  |.:|||||.:.|:|.::||||.|.|||:.|||.|:
  Rat  1156 FTSVERINHYIKTLSLEAPARI---KNKAPPHDWPQEGEITFENAEMRYRENLPLVLKKVSFTIK 1217

  Fly  1336 GGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGS 1400
            ..||:|||||||:|||||.:||||::|.:||.|.||||.|:.:||..|||:||||||:||||||:
  Rat  1218 PKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLTIIPQEPVLFSGT 1282

  Fly  1401 LRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKT 1465
            :|.|||||...|:::||.|||.:|:|..:..|...|..|:.|.|:|.|||:|||:|:||||||..
  Rat  1283 VRSNLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHC 1347

  Fly  1466 KVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTE 1530
            |:|:|||||||:|.|||.|||:|||..|.:||:|||||||:|:|.||:::||.:||::||.:|:.
  Rat  1348 KILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSV 1412

  Fly  1531 LLDNPKSAFYSMAKDA 1546
            ||.|..|.||:|...|
  Rat  1413 LLSNDSSRFYAMCAAA 1428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 494/1446 (34%)
ABC_membrane 338..601 CDD:279056 69/267 (26%)
ABCC_MRP_domain1 649..848 CDD:213217 105/271 (39%)
ABC_membrane 988..1260 CDD:279056 93/292 (32%)
ABCC_MRP_domain2 1308..1528 CDD:213211 131/219 (60%)
Abcc5NP_446376.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12..38
PLN03130 100..1424 CDD:215595 489/1430 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 499..569 3/69 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 795..822 9/74 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345030
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.660

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