Sequence 1: | NP_723772.2 | Gene: | MRP / 34686 | FlyBaseID: | FBgn0032456 | Length: | 1549 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_000483.3 | Gene: | CFTR / 1080 | HGNCID: | 1884 | Length: | 1480 | Species: | Homo sapiens |
Alignment Length: | 1507 | Identity: | 389/1507 - (25%) |
---|---|---|---|
Similarity: | 692/1507 - (45%) | Gaps: | 266/1507 - (17%) |
- Green bases have known domain annotations that are detailed below.
Fly 225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNV--RKNYKN 287
Fly 288 KARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQ 352
Fly 353 VLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKAL 417
Fly 418 RISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVM 482
Fly 483 IILIPVNGVIASRIKTYQIRQMKYKD-------ERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDI 540
Fly 541 RDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPL 605
Fly 606 T-ILPMLSVDIAETQVSVNRINKFLNSEE---LDPN-------------------SVLHDSSKPH 647
Fly 648 PMSIENGEFSWGDEI------------TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEK 700
Fly 701 LAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIG 765
Fly 766 EKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTH 830
Fly 831 GVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFII------------------------- 870
Fly 871 ---------------QHLQEGNEEEEELNQIKRQISS-------------------TADVPELLG 901
Fly 902 TVEKAIKLA----RTESLSDSISVTSAD------------SLM----GGGGSLRRRTKRQDSHDS 946
Fly 947 VASAASLKKKQEVEGKLIETEKSQTGGVEFA--------------------------VYKHYI-- 983
Fly 984 -KSVGIFLSVATLVLNFVFQAFQIGSN---LWLTQWANDQNVANDTGLRD--------------- 1029
Fly 1030 --MYLGVYG---AFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRL 1089
Fly 1090 LNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATS 1154
Fly 1155 RQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIR 1219
Fly 1220 LEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYG 1284
Fly 1285 E-------TKQEAPWE---------LEQDKNKPKN-WPQEGRVEFQNFQVRYREGLDLVLRGVSF 1332
Fly 1333 NIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLF 1397
Fly 1398 SGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALL 1462
Fly 1463 RKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFAS 1527
Fly 1528 PTELLDNPKSAF 1539 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
MRP | NP_723772.2 | MRP_assoc_pro | 14..1548 | CDD:188098 | 389/1507 (26%) |
ABC_membrane | 338..601 | CDD:279056 | 63/269 (23%) | ||
ABCC_MRP_domain1 | 649..848 | CDD:213217 | 81/210 (39%) | ||
ABC_membrane | 988..1260 | CDD:279056 | 68/294 (23%) | ||
ABCC_MRP_domain2 | 1308..1528 | CDD:213211 | 81/219 (37%) | ||
CFTR | NP_000483.3 | CFTR_protein | 1..1480 | CDD:273530 | 389/1507 (26%) |
ABC_membrane | 85..303 | CDD:279056 | 56/224 (25%) | ||
ABCC_CFTR1 | 389..670 | CDD:213258 | 89/285 (31%) | ||
CFTR_R | 639..849 | CDD:291094 | 31/219 (14%) | ||
Disordered R region. /evidence=ECO:0000269|PubMed:10792060 | 654..831 | 30/186 (16%) | |||
ABC_membrane | 866..1147 | CDD:279056 | 69/292 (24%) | ||
ABCC_CFTR2 | 1208..1480 | CDD:213256 | 87/232 (38%) | ||
Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936 | 1386..1480 | 15/53 (28%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1452..1480 | ||||
PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976 | 1478..1480 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C165151590 | |
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E2759_KOG0054 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D138195at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
5 | 4.750 |