DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC4

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1360	Identity:	501/1360 - (36%)
Similarity:	765/1360 - (56%)	Gaps:	137/1360 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289
            |...|:..||:.:.|.:.:...|::..|||.|::.:.|:|....:.......|::.|       .
Human    12 PLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEV-------L 69

  Fly   290 RVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVL 354
            |.|..||                     ..|:...|.|.:...:|...:..|..::....||..|
Human    70 RAENDAQ---------------------KPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFL 113

  Fly   355 SLIISFVE---AQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKA 416
            ..||::.|   ..|:........||.:|.........:...||:.:...|:|:|.|:.:.|||||
Human   114 GKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKA 178

  Fly   417 LRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAV 481
            ||:||....::|.|:||||::.|..:|.::|.:|:.:|:.|||.......||.::|.|.|||:||
Human   179 LRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAV 243

  Fly   482 MIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIA 546
            :|||:|:.........:.:.:...:.|.|::.||||::||:::|:||||.||...:.::|.|||:
Human   244 LIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEIS 308

  Fly   547 -TLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTI-LP 609
             .|||:.......:..:|.:..:| .|||.||||....  ::..:|.|::.|:..::|.:|: .|
Human   309 KILRSSCLRGMNLASFFSASKIIV-FVTFTTYVLLGSV--ITASRVFVAVTLYGAVRLTVTLFFP 370

  Fly   610 MLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW---GDEITLRNINIEV 671
            .....::|..||:.||..||..:|:...:....|.....:.:::....|   .:..||:.::..|
Human   371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435

  Fly   672 KKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYD 736
            :.|.|:|:||.||:||||::.|.|||:....|:|:..|::|||.||.|:.:.|:|.|||||:.|:
Human   436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYE 500

  Fly   737 RKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAV 801
            ::||.|||.||||:.|:.:|..||||.||::|..||||||.|::||||||.|||:||||||||||
Human   501 KERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAV 565

  Fly   802 DAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFA 866
            ||.|.:|:||..|..  ||..|..:||||.:.:|.....|.::|.|::.:.||:.:.:|:...|.
Human   566 DAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFG 628

  Fly   867 DFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISV----TSADSL 927
            ..    |::.|||.|:              |.:.||     ...|..:.|:| ||    :|..||
Human   629 SL----LKKDNEESEQ--------------PPVPGT-----PTLRNRTFSES-SVWSQQSSRPSL 669

  Fly   928 MGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKS-----VG 987
            ..|.         .:|.|:.....:|.::...|||           |.|..||:|.::     |.
Human   670 KDGA---------LESQDTENVPVTLSEENRSEGK-----------VGFQAYKNYFRAGAHWIVF 714

  Fly   988 IFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNV--------ANDTGLRDM--YLGVYGA----- 1037
            |||    ::||...|...:..:.||:.|||.|::        .|.|...|:  |||:|..
Human   715 IFL----ILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVAT 775

  Fly  1038 --FGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVV 1100
              ||..:.:|.::.:|       .:::|:||::...|::..|. |||..||||:||.||.|:..:
Human   776 VLFGIARSLLVFYVLV-------NSSQTLHNKMFESILKAPVL-FFDRNPIGRILNRFSKDIGHL 832

  Fly  1101 DEELPATMDSFMTFIFMVLATIVVISLSTPI--FLAV-IVPIAFLYYFAQRFYVATSRQLMRLES 1162
            |:.||.|   |:.||..:|..:.|:|::..:  ::|: :||:..::.|.:|:::.|||.:.||||
Human   833 DDLLPLT---FLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLES 894

  Fly  1163 VSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGN-- 1225
            .:|||::||.|.::.|..|||||...:|..|..||..|.:....:..:..:||.|:||:.:..
Human   895 TTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMF 959

  Fly  1226 -LIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQE 1289
             :|:.|.||  :|....:.|.|||::||||.:.....|.||.|:::|..::||||:.||.:.::|
Human   960 VIIVAFGSL--ILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKE 1022

  Fly  1290 APWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLT 1354
            ||||.:  |..|..||.||.:.|.|....|..|..|||:.::..|:..||||||||||||||||.
Human  1023 APWEYQ--KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLI 1085

  Fly  1355 LALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKA 1419
            .||||:.|.. |:|.||.:....:|||.||.:::||||:||||:|::|.|||||...||:|:|.|
Human  1086 SALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNA 1149

  Fly  1420 LELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDL 1484
            |:...||..::.|...::.|:||.|.|.|||||||||||||:|||.::|::|||||.||..||:|
Human  1150 LQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214

  Fly  1485 IQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544
            |||.||.:|..|||||||||||||:||||::|||.|::.|:..|..||.|.:|.||.|.:
Human  1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQ 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	501/1360 (37%)
		ABC_membrane	338..601	CDD:279056	87/266 (33%)
		ABCC_MRP_domain1	649..848	CDD:213217	97/201 (48%)
		ABC_membrane	988..1260	CDD:279056	97/294 (33%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	123/219 (56%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	498/1353 (37%)
		ABC_membrane	96..365	CDD:294371	88/271 (32%)
		ABCC_MRP_domain1	410..610	CDD:213217	97/201 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		10/40 (25%)
		ABC_membrane	718..991	CDD:279056	94/285 (33%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	123/219 (56%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760