Protein Alignment MRP and abcc9

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_031754288.1
• Gene: abcc9 / 101733439
• XenbaseID: XB-GENE-6074535
• Length: 1577
• Species: Xenopus tropicalis
• Alignment Length: 1707
• Identity: 517/1707 - (30%)
• Similarity: 822/1707 - (48%)
• Gaps: 311/1707 - (18%)

  Fly    12 FCGST--FWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYL-------KASLDRN- 66
            ||||.  .:|.......|     .|| ..||...|..|. .|:.|...::       |..:..|
 Frog     5 FCGSKNFSYNVNAGVLNN-----ICF-LDALNLVPHVFL-LFITFPILFIGWGSQSSKVQIHHNT 62

  Fly    67 ---IPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGP-IIKF--ATFLLLF 125
               .|.:.|   :.::...||.:...::...:|   .|:::....|.::.| ||.|  ||..:::
 Frog    63 WLHFPGHNL---RWILTFALLFVHVCEIAEGIV---SDAKMSSCHLHLFMPAIIGFIAATTSIIY 121

  Fly   126 IFIPLNRKYGVQTTG------CQFIFWFLL----TVLSIPRCRTEVRLDAERQKILNSQQPSEQD 180
            .       :.::|:.      ..|::|.|.    |:..:..|...:.|...|
 Frog   122 Y-------HNIETSNFPKLLLALFLYWVLAFISKTIKLVKYCENGIGLHQLR------------- 166

  Fly   181 FSWEEYQFVSFFIFFTFTSIMLI----LNCFADGMPRQTKY--------QRGENEIPELSASF-- 231
                          |..|.||::    |......:.|..||        .:...::.:|...|
 Frog   167 --------------FCITGIMVVLYGLLMAVEINVIRVRKYVFFSSQQKVKPPEDLQDLGVRFLQ 217

  Fly   232 -----LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKN--KA 289
                 ||:.||.|.:.:.:..::.|::.|.:..|          ||     ......||.:  .|
 Frog   218 PFVNLLSKATYWWMNPLIISAHKRPIDLKTIGKL----------PI-----AMRALTNYLSLKTA 267

  Fly   290 RVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVL 354
            ..|.|.:.      .:.||.:        .||...||::||...|..:..:...|.|.||.|..:
 Frog   268 YEEQKKKL------VDRPHKD--------PSIWKAIYRAFGRPILLSSTFRYLADLLGFAGPLCI 318

  Fly   355 SLIISFVEAQDAEP----------------EWKGIL-----YAVLLFV-LAAAQTFILGQYFHRM 397
            |.|:..:::::..|                ..||::     .|||||: |...:||:...|:..:
 Frog   319 SGIVQLLDSRNKGPTDQDFPKTNFSSVYFLSSKGLIENYYVLAVLLFLALILQRTFLQASYYVTI 383

  Fly   398 FIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQI 460
             ..|:.:|.||::.||.|.||:  ||.:..|.|:|:|.||:|::..:.|........:|:.|:||
 Frog   384 -ETGINLRGALLSMIYNKILRLSTSNMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPIQI 447

  Fly   461 GLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLK 525
            .:.:..|.:.:|.|.|.|.||:::|.|:...||:::...|...:.|..||:|..||:|.|||:||
 Frog   448 IMGVILLHKLVGVSALVGAAVIVLLAPMQYFIATKLAEVQKNTLDYSTERLKKTNEILKGIKLLK 512

  Fly   526 LYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEK 590
            |||||..|...|.:.|.||:.:|::.|...:.:.|:.:..|....|.||.|:...| ::.|:...
 Frog   513 LYAWENIFCNSVEETRIKELKSLKTFALHTSLSIFMNAAIPIAAVLATFVTHAYVS-SSHLTPAN 576

  Fly   591 VLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEEL-------DPNSVLHDSSKPHP 648
            ...|::||.::..||.:|..:.....:..|||.::|:|..|:|:       ...::..:|.:.||
 Frog   577 AFASLSLFHILVTPLFLLSTVVRFAVKALVSVQKLNEFFTSDEIREDGFRNGETTLPFESCRKHP 641

  Fly   649 -------------------------------------MSIENGEFSWGDEI-TLRNINIEVKKGS 675
                                                 :.:..|.||||..: ||.||:|::..|.
 Frog   642 GIHSRAFNRKQPLRYQMDKYDQAPKRQVRTSDTEDAALKVCGGFFSWGTGLATLANIDIQIPTGE 706

  Fly   676 LVALVGTVGSGKSSVVQAFLGEMEKLAG--VVNTVG--------------------------KLA 712
            |..:||.||.||||::.|.||||:.|.|  |.|..|                          .:|
 Frog   707 LTMIVGQVGCGKSSLLLAILGEMQTLEGRVVWNKFGSQRRAPGSSANGWDSACGSERSKNRHSVA 771

  Fly   713 YVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQ 777
            |..|:.|:.|||:.:||.||..::::||..|.|||:|:.|||:|..||.|||||:||||||||:|
 Frog   772 YAGQKPWLLNATLEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQ 836

  Fly   778 RISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILA-----RKSRVLVTHGVTFLPQ 837
            ||.:|||:|.:.::..||||.||:|.|:..|:.:|     |||.     :::.|||||.:.:||.
 Frog   837 RICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE-----GILKFLREDKRTVVLVTHKLQYLPH 896

  Fly   838 VDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQE-GNEEEEELNQIKRQISSTADVPELLG 901
            .|.|..:|.|.:...||...:..|...    :.:|.:. .|.:::||
 Frog   897 ADWIIAMKDGSVLREGTLKDIQNNDNE----LYEHWKTLMNRQDQEL------------------ 939

  Fly   902 TVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIET 966
                       |..||:..||           :.|:|.|:..:...|...:.::::|.|    |.
 Frog   940 -----------EKDSDADQVT-----------MERKTLRRAMYSREAKVQAEEEEEEEE----EE 978

  Fly   967 EKSQTGGVEFAVYK--------HYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQW-------- 1015
            ::.:|......:..        .|:.|.|..|....:....:..:..:..:.||..|
 Frog   979 DEDETMSTAMRLRTKFPWRTCWRYLTSGGYLLLFLMIFSKLLKHSVIVAIDYWLASWTSETSNIS 1043

  Fly  1016 -ANDQNVANDTGLRDMY------LGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVII 1073
             |...||.:.:.|..:.      ..|..|.|.   ||...|.:.|...|..|||.:|:.||..||
 Frog  1044 YAQSDNVTSASELSSIQSYYVTGFSVLSATGI---VLCLIASLTVEWMGLNAAKNLHHNLLKKII 1105

  Fly  1074 RGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVP 1138
            ...: ||||.||:|.:||.||.|.:::|:.:|.|::|......:.|:.|.|||.:|||.:..::|
 Frog  1106 LAPI-RFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGVISYATPISMVALLP 1169

  Fly  1139 IAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQ 1203
            :...:||.|:::...|:.|..|:..::.|:..|||||..|.:||||:....||.:......|.|.
 Frog  1170 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNN 1234

  Fly  1204 VCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSS 1268
            :.......|||||.:|.:.:|..|:|.|::|::..| .:.|:|||.::|||.||..|||:||..:
 Frog  1235 LAYLFLSAANRWLEVRTDYLGACIVLTAAVFSITYG-LDSGIVGLGLTYALTVTNYLNWVVRNLA 1298

  Fly  1269 DIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFN 1333
            |:|..|.:|:::..:...:.|......:.:..|::|||.|.:...:..|||......||:.:...
 Frog  1299 DLEVQIGAVKKVNSFLNIESECYEGSMEQQQVPEDWPQSGEIRISDLCVRYENNHKPVLKHLKAY 1363

  Fly  1334 IQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFS 1398
            |:.|:||||.||||:|||||:||.||:::...|:|.|||:||:.:.|:.|||||:||.|||:|||
 Frog  1364 IKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLNTLRSRLSIILQDPILFS 1428

  Fly  1399 GSLRINLDPFEIKTDDE-IWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALL 1462
            ||:|.|||| |.|..|| :|:.|:::.||:.||:|..||:..:.|||||.|||||||.|||||.:
 Frog  1429 GSIRFNLDP-ECKCSDERLWEGLDIAQLKNLVKALPGGLDAMVTEGGENFSVGQRQLFCLARAFV 1492

  Fly  1463 RKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFAS 1527
            |.:.:|::|||||::|:.|::::||.:.|.|.:.||:|||||::|||..|..||:.:|.|:|..:
 Frog  1493 RNSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTGDVAIVMRRGNILEHDT 1557

  Fly  1528 PTELLDNPKSAFYSMAK 1544
            |..||....|.|.|..:
 Frog  1558 PGNLLAQEDSIFASFVR 1574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	515/1705 (30%)
		ABC_membrane	338..601	CDD:279056	89/286 (31%)
		ABCC_MRP_domain1	649..848	CDD:213217	97/232 (42%)
		ABC_membrane	988..1260	CDD:279056	91/286 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	112/220 (51%)
abcc9	XP_031754288.1	MRP_assoc_pro	222..1574	CDD:188098	470/1441 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010