Protein Alignment MRP and ABCC5

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 1454
• Identity: 496/1454 - (34%)
• Similarity: 752/1454 - (51%)
• Gaps: 235/1454 - (16%)

  Fly   216 KYQRG-----------ENEIPELSASFLSRITYQWFDKMALKGY-RNPLEEKDLWDLRPQDS--- 265
            ||..|           :::.|..:|...|.:|:.|...:|...: :..|..:|:|.|...:|
Human    80 KYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDV 144

  Fly   266 -CSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSF 329
             |..:..::....|:           |.|.|                       ||:...::...
Human   145 NCRRLERLWQEELNE-----------VGPDA-----------------------ASLRRVVWIFC 175

  Fly   330 GGVFLFGALMKLFTDTLTFAQPQ-VLSLIISFVEAQDAEPEWK-----GILYAVLLFVLAAAQTF 388
            ....:...:..:.|....|:.|. ::..::.:.:|.::..::.     |:|...::...:.|.|:
Human   176 RTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW 240

  Fly   389 ILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMI 453
            .|.      :..|:|:|.|::...::|.|::.|.  ||.::||::|:.:.|.||..|.....:::
Human   241 ALN------YRTGVRLRGAILTMAFKKILKLKNI--KEKSLGELINICSNDGQRMFEAAAVGSLL 297

  Fly   454 WSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQ-MKYKDERVKLMNEV 517
            ...|:...|.:.:....|||:...|.||.|:..|.. :.|||:..|..|: :...||||:.||||
Human   298 AGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM-MFASRLTAYFRRKCVAATDERVQKMNEV 361

  Fly   518 LSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV---SLVTFATYVL 579
            |:.||.:|:|||..:|.:.|..||::|...|....|..   |.....||.:|   |:|||:.::
Human   362 LTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQ---SITVGVAPIVVVIASVVTFSVHM- 422

  Fly   580 TSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSS 644
             :....|:..:....:.:|:.|...|.:.|.....::|..|:|:|.......||:  :.:.:..:
Human   423 -TLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV--HMIKNKPA 484

  Fly   645 KPH-PMSIENGEFSW-------------------------------------------------- 658
            .|| .:.::|...:|
Human   485 SPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHL 549

  Fly   659 --------------GDEI---------TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEK 700
                          |..|         ||.:|::|:::|.||.:.|:|||||:|::.|.||:|..
Human   550 LLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614

  Fly   701 LAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIG 765
            |.|.:...|..|||.|||||.|||:|||||||:.||.:|||.|:::|.||.|:.||.:.||||||
Human   615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIG 679

  Fly   766 EKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTH 830
            |:|.||||||:||||||||:|||..:|:|||||||:|||||.|||...|  :..|..|:.:.|||
Human   680 ERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAI--RKHLKSKTVLFVTH 742

  Fly   831 GVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTAD 895
            .:.:|...|.:..:|.|.|:|.||.::|:...|.:|. |..:|..|.....|:|..|
Human   743 QLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYAT-IFNNLLLGETPPVEINSKK-------- 798

  Fly   896 VPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEV- 959
              |..|:.:|                                     |.|......|:||::.|
Human   799 --ETSGSQKK-------------------------------------SQDKGPKTGSVKKEKAVK 824

  Fly   960 --EGKLIETEKSQTGGVEFAVYKHYIKSVG---IFLSV-ATLVLNFVFQAFQIGSNLWLTQW--- 1015
              ||:|::.|:...|.|.::||..||::.|   .||.: |..:||....||   |..||:.|
Human   825 PEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF---STWWLSYWIKQ 886

  Fly  1016 -ANDQNV--ANDTGLRD---------MYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNEL 1068
             :.:..|  .|:|.:.|         .|..:|........:|.....|:...|..:|:..:|:||
Human   887 GSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDEL 951

  Fly  1069 LAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL 1133
            ...|:| |..:|||.||.||:||.||.|||.||..||...:.|:..:.:|...:.:|:...|.||
Human   952 FRRILR-SPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFL 1015

  Fly  1134 AVIVPIAFLY---YFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEES 1195
            ..:.|:..|:   :...|..:   |:|.||:::::||..||.:.::.|.:||.|||.|..|:...
Human  1016 VAVGPLVILFSVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRY 1077

  Fly  1196 DAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQT 1259
            ...:|.||...:....|.||||:||:::...:|....|..|| .||..|...||::|||:|:|..
Human  1078 QELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGL 1142

  Fly  1260 LNWLVRMSSDIETNIVSVERIKEYGET-KQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGL 1323
            ..:.||::|:.|....|||||..|.:| ..|||..::.....| :|||||.|.|:|.::||||.|
Human  1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSP-DWPQEGEVTFENAEMRYRENL 1206

  Fly  1324 DLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLT 1388
            .|||:.|||.|:..||:|||||||:|||||.:||||::|.:||.|.||||.|:.:||..|||:|:
Human  1207 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLS 1271

  Fly  1389 IIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQ 1453
            ||||:||||||::|.|||||...|:|:||.|||.:|:|..:..|...|..|:.|.|:|.|||:||
Human  1272 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1336

  Fly  1454 LVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLD 1518
            |:|:||||||..|:|:|||||||:|.|||.|||:|||..|.:||:|||||||:|:|.||:::||.
Human  1337 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1401

  Fly  1519 KGQIIEFASPTELLDNPKSAFYSM 1542
            :||::||.:|:.||.|..|.||:|
Human  1402 QGQVVEFDTPSVLLSNDSSRFYAM 1425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	496/1454 (34%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	492/1432 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		0/36 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		11/79 (14%)