DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcc12

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_002937916.3	Gene:	abcc12 / 100493828	XenbaseID:	XB-GENE-6465370	Length:	1430	Species:	Xenopus tropicalis

Alignment Length:	1452	Identity:	477/1452 - (32%)
Similarity:	762/1452 - (52%)	Gaps:	194/1452 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 NEIPELSASFLSRITYQWFDKMALKGYR-NPLEEKDLWDL----RPQDSCSEVMPIFAHHWNQNV 281
            |:.|..:|...|.:|..|...:|.|.|: :.|:..|||.|    ..:.:|..:..:    |.:.:
Frog    28 NQHPIDNAGLFSFMTLNWITPLARKAYKLSELQMNDLWSLPFHESSETNCQRLQSL----WEEEL 88

  Fly   282 RKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTL 346
                                        :.:|::|...|::  :::......|...|..:.|.|.
Frog    89 ----------------------------QNHGKRKASLSLV--LWRFCRTRSLLAFLSLIITMTA 123

  Fly   347 TFAQPQV-LSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALIN 410
            :|..|.: :..::.:......:..: |::.|..:|.....:::....::...:..|:|::.|::.
Frog   124 SFIGPAIFIRALLEYANTLKHDLRY-GLILASGIFAAELVRSWSFALHWAMNYRTGVRLKGAVLA 187

  Fly   411 AIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIG-LALYFLWQQLGPS 474
            ..::|.|::..|  .:...||::|:.:.|.||..|..:...|:.:.|: || :.|.:....||||
Frog   188 LAFKKMLKLKQS--NDIRTGELLNMCSSDGQRLFEAASIGCMLAAGPV-IGIMGLVYTALFLGPS 249

  Fly   475 VLAGLAVMIILIPVNGVIASRIKTY-QIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVL 538
            .|.|.:|.||..|.. ::||::..| :.:.:...|.||:||||:|:.||.:|:||||.:|..::.
Frog   250 ALLGSSVFIIFYPFM-MLASKLTAYFRKKCIVVTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQ 313

  Fly   539 DIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVL-TSEANQLSVEKVLVSIALFDLMK 602
            |||.:|...|....|:.:.||   ..||.:|.:.:..|:.| .:....|:..:....:.:|:.|.
Frog   314 DIRSEEKTFLEKAGYVQSITS---GVAPVVVVVASVCTFTLHMALGYNLNAAEAFTVVTVFNSMT 375

  Fly   603 LPLTILPMLSVDIAETQVSVNRINKFLNSEELD--PNSVLHDSSKPHPMSIENGEFSWGDEI--- 662
            ..|.::|:.....:|..:|::|..|....||.|  .|..|..:..   :......|||..::
Frog   376 SALKMIPLAVKAASEASISISRFQKLFLMEESDMRNNQRLLSNDL---IDFSGAYFSWSSDVRSS 437

  Fly   663 ----------------------------------------------------TLRNINIEVKKGS 675
                                                                .|.|||..|:|..
Frog   438 TLEKQKEAEQKQEEFKETQNLINGHYLFSSSESKQIVNGTNASEYIVCEHKAALININFTVQKSK 502

  Fly   676 LVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRY 740
            |:.:.|:|||||:|::.:.||:|..|.|.|...|::||..|||||.|.::|:|||||:.|..|:|
Frog   503 LIGICGSVGSGKTSLILSILGQMTLLEGTVTVSGRIAYAAQQAWIFNESLRENILFGEEYKEKKY 567

  Fly   741 NKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHV 805
            .:|:..|.|..||:.|..||||||||:|.||||||:||||||||:||:..:.||||||||||..|
Frog   568 QRVLKTCCLYPDIESLPHGDLTEIGERGTNLSGGQRQRISLARALYSERSVVLLDDPLSAVDVQV 632

  Fly   806 GKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFII 870
            |..:|::.|  |..:..:..:.|||.:.:|.:.|.:.::|.|.|:|.||.::|:|.:|.:| .:.
Frog   633 GAQLFKKAI--KHGMMNRIVLFVTHQLQYLVECDEVLMMKNGSIAEQGTHEELMKYQGDYA-VLF 694

  Fly   871 QHLQEGNEEEEEL-------NQIKRQISSTADVPELLGTVEKAI--KLARTESLSDSISV-TSAD 925
            |.:|:.|..:.::       .|:.||::|:.....:..:.|:..  :|...|......|. .|||
Frog   695 QSMQQVNSIKSDVQCSPMKYEQLDRQVTSSHHATVVQQSKEQGTLSELTNQEETGHFTSEDVSAD 759

  Fly   926 SLMGGGGSLRR----------RTKRQDSHDSVASAASLKKKQEVEGK-------------LIETE 967
            .|......:.|          ..|:.|.:......|...:|..|.|.             |:|.|
Frog   760 HLTHKSEMVNRDFMVTDGQITGCKQADQYGDQEDDADEDEKGSVLGNTIIVNNNERQNRDLMEPE 824

  Fly   968 KSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIG----SNLWLTQW------------- 1015
            :...|.|...:|..|||:.|   .....|||.|...|..|    ||.||:.|
Frog   825 EKGCGSVPCPIYWVYIKAAG---GALFCVLNAVLFIFTTGSMAFSNWWLSYWIKQGSGNTSVVTS 886

  Fly  1016 ---ANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVI--VYLGGF-------QAAKTIHNEL 1068
               .:..|::::..| :.|:.||         ::..|.|:  .::.|:       :|:..:|::|
Frog   887 NVTLSSDNMSDNPDL-EFYIYVY---------ISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQL 941

  Fly  1069 LAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL 1133
            ...::. |..:.||.||:||:||.|:.|||.||..||..::..:..:.:||..:.:||...|.||
Frog   942 FQKVLH-SPLKLFDTTPLGRILNRFTKDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFL 1005

  Fly  1134 AVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAK 1198
            ..::|::.|::...:......|:|.||:::|:||..||.:.::.|.:||:|||....||......
Frog  1006 VSVLPLSILFFLINKVSRVLIRELKRLDNISQSPFLSHVTASLHGITTIQAYNKNTDFILRFQKL 1070

  Fly  1199 VDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNW 1262
            :|.|||..:....|:||||:||:::..::|...|:..|| .|...|...||::|||:|:|....:
Frog  1071 LDINQVPCFLFSCASRWLAVRLDLISMIVITLTSVCIVLMHGHIPPAYAGLAISYAVQLTGLFQY 1135

  Fly  1263 LVRMSSDIETNIVSVERIKEY-GETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLV 1326
            .||:.::.|....|||||..| ...:.|.|  |:..:..||.|||||.:.|:|.::|||:.|.||
Frog  1136 TVRLVTETEARFTSVERINHYIKNLESEEP--LKAKEITPKTWPQEGAITFENVEMRYRDKLPLV 1198

  Fly  1327 LRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIP 1391
            |:.:||:|:..||:|||||||:|||||.:.|||:::.|||.::||...|.::||..||.:|:::|
Frog  1199 LKNISFSIRPKEKIGIVGRTGSGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLP 1263

  Fly  1392 QDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVC 1456
            ||||||.||:|.||||..:.||:|:|.|||.:|:|..|..|...||:|::|.|.|.|||:|||:|
Frog  1264 QDPVLFVGSIRSNLDPLNLHTDEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLC 1328

  Fly  1457 LARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQ 1521
            :||||||.:|||:|||||||:|.|||.|||:|::..|.:||||.|||||||||..|:::|:|||:
Frog  1329 MARALLRSSKVLLLDEATAAIDNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGK 1393

  Fly  1522 IIEFASPTELLDNPKSAFYSMA 1543
            |:||..|:.||.|.||.|::||
Frog  1394 IVEFEKPSVLLSNKKSRFHAMA 1415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	477/1452 (33%)
		ABC_membrane	338..601	CDD:279056	70/266 (26%)
		ABCC_MRP_domain1	649..848	CDD:213217	93/253 (37%)
		ABC_membrane	988..1260	CDD:279056	89/301 (30%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	125/219 (57%)
abcc12	XP_002937916.3	MRP_assoc_pro	27..1415	CDD:188098	475/1450 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010