DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcc6

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_002932264.3	Gene:	abcc6 / 100493037	XenbaseID:	XB-GENE-6465366	Length:	1500	Species:	Xenopus tropicalis

Alignment Length:	1557	Identity:	647/1557 - (41%)
Similarity:	974/1557 - (62%)	Gaps:	93/1557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFY--YLKASLDRNIPWNKLNVSKALV 79
            ||:..:||:|::|||:.||..:.|.|.|..|  .|:...||  ||:......|..:.|:.:|..:
Frog    13 FWDINQTWHTDNPDFSQCFHNSVLNWIPSIF--LFICSPFYVLYLRRHGRGYIRMSALSKAKTCL 75

  Fly    80 NLGLLVITALDLIMALVKKGGD-SELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQF 143
            ...|:::...:|...:.....: .:.|::   :..|:|..::.||....|...|..||:::....
Frog    76 GALLVLVCYTELFYTVWNMTHNVRQAPVF---LISPLILGSSMLLATCIIQYERMQGVRSSALLL 137

  Fly   144 IFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFA 208
            .||.|..:.:..:.||::....       |:.|     ..::.::..|.::|.|.....:|..|.
Frog   138 FFWLLALLCATFQLRTKITTAI-------SEAP-----QIDKLRYTLFVLYFVFVLAQSVLCTFN 190

  Fly   209 DGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIF 273
            |..|..:..::..|..|...:||||::|:.||.::..:||:.||:.:|:|.||..|:..|::.:|
Frog   191 DDPPFFSNLKKESNPCPVSESSFLSKVTFSWFTEIMFRGYKQPLKAEDVWSLRKSDTAEEILTLF 255

  Fly   274 AHHWNQNVRKN--YKNKARVEP----------KAQFSNGNVTFENPHGEKNGRKKGMASIMPPIY 326
            :....:..:|.  .|...|..|          :.:.|...:..:|.|.:.:.:     :::..|.
Frog   256 SKGVEKECKKANLLKEPTRFSPSTLDNDMWISQTEKSEIELLLKNQHIQLSQK-----TLLKVIM 315

  Fly   327 KSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILG 391
            :|||..||..||:..|.....|..|.::.|::..::...| |.|:|.|.||.||:....|:..|.
Frog   316 RSFGLYFLLSALLMTFYTAFLFISPLLVRLLLQLLKDPSA-PSWQGFLVAVFLFICPCCQSLFLH 379

  Fly   392 QYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSA 456
            |:.:..:::|:|:|.|::..:|:|||.||::.:|||:.||||||::.|.|:.|:|.|.:|.:|||
Frog   380 QHDYICYVIGMRLRAAIVGTVYKKALMISSAGRKESSAGEIVNLISTDVQKLMDLATCVNYMWSA 444

  Fly   457 PLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGI 521
            |:.|.:|:|||||.||.:||||:||.|:.:|...|.|..||..|.:|||.||.|:|:::|:|.||
Frog   445 PVTIIVAMYFLWQTLGIAVLAGVAVFILNLPFMTVFAVIIKRVQEQQMKQKDGRIKIISEILQGI 509

  Fly   522 KVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQL 586
            |||||||||.:|.|:|.:.|..|:..:::.|.|.:|...::..:||.|||..|..::...|.|.|
Frog   510 KVLKLYAWENAFMKKVTEFRLMELKAVKTGALLLSGALAVFVASPFWVSLTMFGVFLALDEKNIL 574

  Fly   587 SVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSV-LHDSSKPHPMS 650
            ..||..|:|.|.:::::||.:.||.....|::.||:.|:.||.::|||:|.|| ::||...|.::
Frog   575 DAEKAFVTIILLNILRIPLRMFPMAITLFAQSSVSLKRMVKFFSAEELEPESVDINDSLSKHAIT 639

  Fly   651 IENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAY 713
            |.:|.|:|  .:...|::|||.:.:|:|||:||.||.||:|::.|.||||||:.|.|:.:..:||
Frog   640 IRHGTFTWSSSEPPCLQSINIGIPQGTLVAVVGQVGCGKTSLLSALLGEMEKVEGQVSLMSSVAY 704

  Fly   714 VPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQR 778
            ||||.||.|||.::|:|||:..::..|::|:.||||..|:.|||.|:.|||||||:|||||||||
Frog   705 VPQQTWIPNATFKENVLFGRKMEKCWYDQVVQACALLPDLKILSGGENTEIGEKGVNLSGGQKQR 769

  Fly   779 ISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYV 843
            ||:|||||.:.|:|||||||||||||||:|:||:||||.|:|..|:||||||||:||||:|.|.|
Frog   770 ISIARAVYRNCDVYLLDDPLSAVDAHVGQHLFEQVIGPSGLLKDKTRVLVTHGVSFLPQMDMIIV 834

  Fly   844 IKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIK 908
            :..|.:||.||:::|::..|||::|:..:.::....||...:            :...:::.|:|
Frog   835 MSDGRVSEVGTYNELLQKNGAFSEFLNTYARKSVVFEESYEE------------QTPNSIQGAMK 887

  Fly   909 LARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQ 970
                               |.|..|.|..|..:.  |.||:        |:|   |||.|.:.:.
Frog   888 -------------------MKGKHSARNDTDNET--DDVAN--------EIEADAGKLTEADVAL 923

  Fly   971 TGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVY 1035
            ||.|:.:||..|.|.:|.:..:.:.:...|.||..:..|.|:..||:|..|........:.||||
Frog   924 TGRVKLSVYLEYCKIMGKWYLLISALFFIVQQAASLSYNYWIGLWADDPPVNGTQQHTSLRLGVY 988

  Fly  1036 GAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVC--RFFDITPIGRLLNSFSGDMD 1098
            ...|..|.:..:.|...:.:||...::.:|:.||..|:|   |  .||:.||.|.|.|.|:.:||
Frog   989 SFLGVMQALSIFAASSTIIVGGVSVSRQLHSRLLYSILR---CPLSFFERTPSGNLTNRFAKEMD 1050

  Fly  1099 VVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESV 1163
            ::|..:|..:..|:..:..:...::|||::||:.....:|:..||:|.||||||:||||.||::|
Frog  1051 IIDNTVPQVLMLFIIMMLTIAEILLVISIATPLAAVAFIPLGLLYFFLQRFYVASSRQLKRLDAV 1115

  Fly  1164 SRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLII 1228
            |:||:|:||:|::.|...|||:...:|||::::.:::.||...:.|.:|||||::|.:.:.|.|:
Frog  1116 SKSPLYTHFNESLQGVYVIRAFREQERFIQDNNMRLNMNQRFYFCSFVANRWLSVRCDFLSNFIV 1180

  Fly  1229 LFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPW 1292
            ...::..|| .....||||||:|..:|::|..|...|.:::|:|||.|||||:|||.:.:.||||
Frog  1181 FTVAIVGVLFRDNITPGLVGLAVVNSLRLTGVLKEAVHVATDMETNSVSVERVKEYCDAEPEAPW 1245

  Fly  1293 ELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLAL 1357
             ...:.:...|||.:|::||||:.:|||..|||.|:.|:.:||.|||||||||||||||||||.|
Frog  1246 -TSDNASDLSNWPSKGKIEFQNYGLRYRPDLDLALKNVTASIQQGEKVGIVGRTGAGKSSLTLGL 1309

  Fly  1358 FRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALEL 1422
            |||:|.|.|||.||..||:.:|||.|||::||||||||||||:||:|||||:..:|::||.||:|
Frog  1310 FRILEPATGRICIDEKDISELGLHELRSKITIIPQDPVLFSGTLRMNLDPFDNYSDNDIWVALQL 1374

  Fly  1423 SHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQK 1487
            :|||.|...|..||::...|||||||||||||||||||||||||:|||||||||||||||||||.
Frog  1375 AHLKVFASGLPEGLSYICTEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQN 1439

  Fly  1488 TIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV 1549
            |||.||::||::|||||||||:|..:|:|.|||:|:||.:|..||:| |..|||||:|||::
Frog  1440 TIRKEFEDCTIITIAHRLNTIMDYTRVVVFDKGEIVEFDTPATLLEN-KGLFYSMARDANII 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	646/1554 (42%)
		ABC_membrane	338..601	CDD:279056	110/262 (42%)
		ABCC_MRP_domain1	649..848	CDD:213217	118/200 (59%)
		ABC_membrane	988..1260	CDD:279056	95/274 (35%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	154/219 (70%)
abcc6	XP_002932264.3	MRP_assoc_pro	5..1499	CDD:188098	646/1554 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2529
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.110