Protein Alignment MRP and abcc4

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_002939329.2
• Gene: abcc4 / 100491006
• XenbaseID: XB-GENE-957302
• Length: 1324
• Species: Xenopus tropicalis
• Alignment Length: 1368
• Identity: 510/1368 - (37%)
• Similarity: 793/1368 - (57%)
• Gaps: 136/1368 - (9%)

  Fly   219 RGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRK 283
            :|....|...|:|.|:|.:.|.:.:.:.|::..|||.|::::.|:|:..::......:|.:.::|
 Frog     6 KGSKANPSQHANFCSKIFFWWLNPLFILGHKRKLEEDDMYEVLPEDASRKLGEELQWYWEKELQK 70

  Fly   284 NYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMA-SIMPPIYKSFG--GVFLFGALMKLFTDT 345
                                     .:..|||..:. :|:...:|:|.  |:|.|      |.::
 Frog    71 -------------------------AQNEGRKPRLTKAIIRCHWKTFSVLGLFTF------FEES 104

  Fly   346 LTFAQPQVLSLIISFVEAQDAEPEWKGILYAVL--LFVLAAAQ---TFILGQ----YFHRMFIVG 401
            :...||..|..:||:.|..||...      |||  .::.|||.   |.||..    ||:.:...|
 Frog   105 IRVVQPIFLGNVISYFERYDANDS------AVLANAYINAAALSACTLILAVVHHIYFYHLLRAG 163

  Fly   402 LRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYF 466
            :::|.|:.:.|||||||:||:...::|.|:||||::.|..:|.::|.:|:.:|:.|||.......
 Frog   164 MKLRVAMCHMIYRKALRLSNTAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVL 228

  Fly   467 LWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEP 531
            ||.::|||.|||:||:|||:|:...:.....:.:.:...:.|.|::.||||:||::::|:||||.
 Frog   229 LWMEIGPSCLAGMAVLIILMPLQLCLGKFFTSLRGKTAAFTDTRIRTMNEVISGMRIIKMYAWEQ 293

  Fly   532 SFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIA 596
            ||.:.|.:||.|||..:..::||.|.....:..|..::..|||.||||.  .|.:|..:|.|:::
 Frog   294 SFTELVNNIRKKEINKVLRSSYLRALNLASFFVASKIILFVTFTTYVLL--GNVISASRVFVAVS 356

  Fly   597 LFDLMKLPLTILPMLSVDIA-ETQVSVNRINKFLNSEEL-DPNSVLHDSSKPHPM-SIENGEFSW 658
            |:..::|.:|:....:|:.| |.:||:.||..||..:|: .|...|.:.::.:.: .|::....|
 Frog   357 LYSAVRLTVTLFFPSAVERASEAKVSIRRIKNFLLLDEIFKPALELPEENEENLLVQIQDVTCYW 421

  Fly   659 GDEI---TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWI 720
            ...:   ||:||:..|:.|.|:|::|.||:||||::.|.|||:.|..|.|:..|::|||.||.|:
 Frog   422 DKTLEIPTLQNISCSVRPGELLAVIGPVGAGKSSLLSAVLGELPKDKGFVDIRGRIAYVSQQPWV 486

  Fly   721 QNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAV 785
            .:.|||.|||||:.|.:::|:||:..|||:.|:..|..||||.||::|:.||||||.|::|||||
 Frog   487 FSGTVRSNILFGKEYVQEKYDKVLRVCALKKDMLQLDDGDLTIIGDRGVTLSGGQKARVNLARAV 551

  Fly   786 YSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEIS 850
            |.|||:||||||||||||.||:|:||:.|..  .|.:|..:||||.:.:|.....|.::|.|.:.
 Frog   552 YQDADIYLLDDPLSAVDAEVGRHLFEKCICQ--ALRKKLCILVTHQLQYLSAAKQILILKEGRMV 614

  Fly   851 ESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESL 915
            ..|||.:|:::...||..:      .:||||:....:.|:                ||.:|..:.
 Frog   615 GKGTFQELLQSGIDFASLL------KSEEEEQSQSQEGQL----------------IKSSRNRTF 657

  Fly   916 SDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYK 980
            |.| ||.|.||.:        ::.::.:.|::|:...|        ..|..|....|.|.|.|||
 Frog   658 SQS-SVWSQDSTV--------QSHKEGATDNLAAEPVL--------TAIPEESRSEGTVGFKVYK 705

  Fly   981 HYIKSVGIFLSV-ATLVLNFVFQAFQIGSNLWLTQWANDQ---NV---ANDTGLR------DMYL 1032
            .|..|...:|.: ..|:||.:.|...:..:.||:.|||:|   |:   .|.||.:      .:||
 Frog   706 KYFTSGSSYLMLFVVLLLNILSQVTYVLQDWWLSYWANEQGKLNITSGTNSTGSKTEQLDLTLYL 770

  Fly  1033 GVYGA-------FGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLL 1090
            |||..       ||..:.:|.:..:|.       ||:.:||::...:::..|. |||..||||:|
 Frog   771 GVYAGLTVATIIFGVLRCLLVFHVLVC-------AAQALHNQMFQSLLKAPVL-FFDRNPIGRIL 827

  Fly  1091 NSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSR 1155
            |.||.|:..:|:.:|.|...||..:..:|..|.|.....|..|..::|:..::||.:|:::.|||
 Frog   828 NRFSKDIGHLDDLMPFTFLDFMQVLLQILGVIAVAVAVIPWILIPLLPLVIVFYFLRRYFLDTSR 892

  Fly  1156 QLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRL 1220
            .:.||||.:|||::||.|.::.|..||||:....||.:..||:.|.:....:..:..:||||:||
 Frog   893 DIKRLESTTRSPVFSHLSSSLQGLWTIRAFKAEKRFQDLFDAQQDLHSEAWFLFLTTSRWLAVRL 957

  Fly  1221 EMVGNLIIL---FASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKE 1282
            :.:..:.::   |.|:  :|....:.|.|||::||.:.:..:..|.||.|:::|..::|.||:.|
 Frog   958 DAICAVFVIAIAFGSI--ILAENLDAGQVGLALSYGMTIMGSFQWGVRQSAEVENLMISAERVME 1020

  Fly  1283 YGETKQEAPWELEQDKN-KPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRT 1346
            |.:.::||.||   .|| .|.:||.:|.:.|:|....|.....:|||.::..|:..|||||||||
 Frog  1021 YTQLEKEAEWE---SKNPPPADWPNKGMITFENVNFSYSLDGPVVLRHLNALIRPKEKVGIVGRT 1082

  Fly  1347 GAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIK 1411
            |||||||..||||:.|.. |:|.||....:.:|||.||.:::||||:||||:|::|.|||||:..
 Frog  1083 GAGKSSLIAALFRLAEPE-GKIWIDKYLTSKLGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFDEH 1146

  Fly  1412 TDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAA 1476
            .|:|:|..||...||..|:.|...:..:::|.|.|.|||||||||||||:||:.::|::|||||.
 Frog  1147 ADEELWDVLEEVQLKEAVEELPGKIETQLSESGSNFSVGQRQLVCLARAILRRNRILIIDEATAN 1211

  Fly  1477 VDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYS 1541
            ||..||:|||||||.:|.||||||||||||||:||||::|||.|::.|:..|..||.|.:|.||.
 Frog  1212 VDPRTDELIQKTIREKFAECTVLTIAHRLNTIIDSDKIMVLDAGRVKEYDEPYLLLQNKESLFYK 1276

  Fly  1542 MAK 1544
            |.:
 Frog  1277 MVQ 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	510/1368 (37%)
		ABC_membrane	338..601	CDD:279056	97/271 (36%)
		ABCC_MRP_domain1	649..848	CDD:213217	98/202 (49%)
		ABC_membrane	988..1260	CDD:279056	93/294 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	121/219 (55%)
abcc4	XP_002939329.2	PLN03130	2..1289	CDD:215595	510/1368 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010