Protein Alignment MRP and abcc2

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_004915926.1
• Gene: abcc2 / 100485020
• XenbaseID: XB-GENE-1012796
• Length: 1552
• Species: Xenopus tropicalis
• Alignment Length: 1610
• Identity: 751/1610 - (46%)
• Similarity: 1046/1610 - (64%)
• Gaps: 134/1610 - (8%)

  Fly     6 SSPMDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWN 70
            |..:|.:|||.|||:: ...:.:||...|||||.|||.|..|:|...               ||.
 Frog     2 SKALDSYCGSIFWNSS-VLDSAEPDLPLCFEQTVLVWIPLIFFWLCA---------------PWQ 50

  Fly    71 KLNVSKALV---NLGLLVITALDLIMAL---------------VKKGGDSELPLYDLDVWGPIIK 117
            .:.:.|..|   .:..|.:|...|.:.|               ||...:|..||..:....|.|.
 Frog    51 LIRLCKPGVVKSRITSLYLTKQCLTLLLFFTSIAGIGITVAEHVKAQSNSTEPLPAVLYVNPAIY 115

  Fly   118 FATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFS 182
            .||:||:.:.....|.|..:.||..||||.|..:..:...:|.:|      |.|....|
 Frog   116 AATWLLVLLIHHTRRYYARKDTGILFIFWTLSVICGVFPFQTFIR------KALKDDIP------ 168

  Fly   183 WEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKG 247
             :..:...|||.::...:.||::..:: ....||      |.|||:||||||||:.|::.:.:||
 Frog   169 -DLPRVCLFFISYSLQILTLIISAISE-KNESTK------ENPELTASFLSRITFNWYNSIVVKG 225

  Fly   248 YRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRK------NYKNKARVE---------PKAQF 297
            |:.|||.:|||:|..:|....:..||..|...:|||      ..|||.:.:         .|||
 Frog   226 YKKPLEMEDLWELNEEDKTKNMYEIFEKHMKHDVRKAKKDLEKRKNKRKQKESGIEMNGISKAQ- 289

  Fly   298 SNGNVTFENPHGEKNGRKK---GMASIMP------PIYKSFGGVFLFGALMKLFTDTLTFAQPQV 353
            |...:..|....||..::|   |.|...|      .:.|:|....|..|:.||..|.|.|..||:
 Frog   290 SQDILVMEEKKKEKKKKEKSIDGTAKDYPKRWLIKTLIKTFPSTLLTSAIFKLLHDLLAFVSPQI 354

  Fly   354 LSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALR 418
            |.::::|. |..::.:|:|..|||||.|.|..|:|:|.||||..|::|:|:|:.|:.|:|:|||.
 Frog   355 LKVMVTFT-ADPSQHQWQGFFYAVLLLVTALLQSFLLQQYFHGCFVLGMRVRSLLMAAVYKKALT 418

  Fly   419 ISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI 483
            :||:.:|||||||.||||:.||||||:||.:::::||:||||.:::.|||::|||||||||.|||
 Frog   419 VSNAIRKESTVGETVNLMSADAQRFMDLTNFIHLLWSSPLQIAISIVFLWEELGPSVLAGLGVMI 483

  Fly   484 ILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATL 548
            :|||:|.|:|:..:..|::.||.||:|:|:|||:|:|||:|||||||||||.||.:||:||:..:
 Frog   484 LLIPINAVLATVSRKLQMKNMKNKDKRMKIMNEILNGIKILKLYAWEPSFENQVQEIREKELKDM 548

  Fly   549 RSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSV 613
            ....||::.:.|:::|||||||:.|||.||....:|.|:.||...||:||::::.||.:||||..
 Frog   549 LHFTYLHSVSLFVFTCAPFLVSVATFAVYVAVDPSNVLNAEKAFTSISLFNILRFPLAMLPMLIS 613

  Fly   614 DIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSL 676
            .:.:|.||..|:.|:|..:.||.:::..|.:....:...:..|||.::.  .:.|:|:::|:|:|
 Frog   614 SMVQTSVSSARLEKYLGGDNLDTSAIRCDPNIDAAVQFSDATFSWEEDANPAVNNVNLDIKEGNL 678

  Fly   677 VALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYN 741
            ||:||.|||||||:|.|.||||:.:.|.:|..|.:|||||||||||||:::|||||...|.:||.
 Frog   679 VAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNNILFGSKMDEERYQ 743

  Fly   742 KVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVG 806
            ||::||||..|:::|...|.:||||||||||||||||:|||||||:|||:|:|||||||||||||
 Frog   744 KVLEACALLPDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYILDDPLSAVDAHVG 808

  Fly   807 KHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQ 871
            |||||:|:||.|:|..|:|:||||||:||...|.|.|:....::|:|::..|..|.||||:|:..
 Frog   809 KHIFEKVVGPNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTLQANNGAFAEFLRL 873

  Fly   872 HLQE------------GNEEEEELNQIKRQISSTADVPE--LLGTVEKAIKLARTESLSDSISVT 922
            :.::            |.::|::.:|::     ||:|.|  :..||::...:.:.:..|.|::
 Frog   874 YAKQNDQTDNEATVFTGEDDEDDGDQVE-----TAEVIEDIVASTVKRENSMRQRKRSSVSMN-- 931

  Fly   923 SADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVG 987
                     |:|||..|     |.......:........||||.|..:||.|:|.:|..|:::||
 Frog   932 ---------GTLRRSVK-----DVTKKKTGIGSNDTKGQKLIEKETVETGKVKFKLYLKYLRAVG 982

  Fly   988 ----IFLSVATLVLNFVFQAFQIGSNLWLTQWAND----QNVANDTGLRDMYLGVYGAFGFGQGV 1044
                .::.|:.::.|..|    :|.|:||:.|..|    .|:......|||.:||:||.|..|.:
 Frog   983 WGFSFWIFVSYILQNAAF----VGQNIWLSDWTGDAEKYYNITYPASQRDMRVGVFGALGVAQAL 1043

  Fly  1045 LAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMD 1109
            .......:|..|..:|::.:|.:||..|:|..: ||||.||.||::|.|:.|:..|||.:|.:..
 Frog  1044 FVLLGAFLVSGGAVRASRMLHTQLLHNILRVPM-RFFDTTPTGRIVNRFAKDILTVDETIPMSFR 1107

  Fly  1110 SFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSE 1174
            |::.....|:.|:.:|.|:||||.|||||:|..|||.|||||.|||||.||:||:||||||||.|
 Frog  1108 SWIACFLGVIGTLFIICLATPIFAAVIVPLAIFYYFVQRFYVTTSRQLRRLDSVTRSPIYSHFGE 1172

  Fly  1175 TVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLG- 1238
            ||:|.|.||||...|||::.::..:|.||...|..:::|||||||||.||||.:.||:||||||
 Frog  1173 TVSGLSVIRAYGHQDRFLQHNEDTIDNNQKSVYSWIVSNRWLAIRLEFVGNLTVFFAALFAVLGR 1237

  Fly  1239 GQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKN 1303
            |..:.|.||||:|.||.:||||||||||:|::|||||:|||:.||.:.::||.|  .:|...||:
 Frog  1238 GTVDSGTVGLSISSALNITQTLNWLVRMTSELETNIVAVERVDEYIKVEREAQW--VEDHRPPKD 1300

  Fly  1304 WPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRI 1368
            ||::|.|:|.:::||||..|||||:|:|..|...|||||||||||||||||..:|||||:|||:|
 Frog  1301 WPEKGVVQFVDYKVRYRPELDLVLQGISCTINSMEKVGIVGRTGAGKSSLTNCIFRIIESAGGKI 1365

  Fly  1369 SIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLA 1433
            .|||:||||:|||.||.:|||||||||||||:||:|||||...||::|||||||||||.||:.|.
 Frog  1366 MIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMNLDPFNQYTDEDIWKALELSHLKPFVEGLQ 1430

  Fly  1434 AGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTV 1498
            ..|.||::|||||||||||||||||||||||:|:|:|||||||||||||:|||:|||:||.:|||
 Frog  1431 EKLFHEVSEGGENLSVGQRQLVCLARALLRKSKILILDEATAAVDLETDNLIQRTIRSEFADCTV 1495

  Fly  1499 LTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANL 1548
            |||||||:||:||.:::|||.|:||||.||.|||.. :..|:||||||.:
 Frog  1496 LTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDELLQR-QGHFFSMAKDAGI 1544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	748/1600 (47%)
		ABC_membrane	338..601	CDD:279056	138/262 (53%)
		ABCC_MRP_domain1	649..848	CDD:213217	121/200 (61%)
		ABC_membrane	988..1260	CDD:279056	130/276 (47%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	160/219 (73%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	748/1600 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I1974
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030