Protein Alignment MRP and abcc8b

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_021323602.1
• Gene: abcc8b / 100329706
• ZFINID: ZDB-GENE-120215-45
• Length: 1607
• Species: Danio rerio
• Alignment Length: 1645
• Identity: 507/1645 - (30%)
• Similarity: 786/1645 - (47%)
• Gaps: 279/1645 - (16%)

  Fly    49 WAFVIFDFYYLKASLDRNIPWNKLNVSKAL---VNLGLLVITALDLIMAL--VKKGGDSELPLYD 108
            |.......:.|...:...|..:..|.|:.|   :..||.::.|:..|:..  ::.....:|.:..
Zfish    90 WLLTAILLFLLVCEIAEGIVSDGFNQSRHLHLYMPAGLAILAAITSIIYYHNIETSNFPKLLIAL 154

  Fly   109 LDVWGPIIKFATFLLLFIFIPLNRKY---GVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKI 170
            |..|  .:.|.|..:.|:      ||   |:.....:|....||.:|.......||.:...|:
Zfish   155 LIYW--TLAFVTKTIKFV------KYDDHGIGLRQLRFCITGLLALLYGLMLGVEVNVILRRR-- 209

  Fly   171 LNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASF---- 231
                      :.|                       ||  .|.:.|   ..:::.:|...|
Zfish   210 ----------YMW-----------------------FA--CPTEVK---PPDDLQDLGVRFLQPF 236

  Fly   232 ---LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEP 293
               ||:.||.|.:......::.|::.|.:..| |:.     |...::.  |.:||.:
Zfish   237 VNLLSKSTYWWMNTFITSAHQRPIDLKTIGKL-PKS-----MRALSNF--QQLRKAF-------- 285

  Fly   294 KAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLII 358
            .:|..:|.|..:           |...:...:.::||...|.....:..:|.|.||.|..:|.|:
Zfish   286 DSQMESGCVHLQ-----------GSGWMWRALRQAFGAPLLLSICFRFISDLLGFAGPLCISGIL 339

  Fly   359 SFVEAQD--AEPEWK--GI-------------LYAVLLFV-LAAAQTFILGQYFHRMFIVGLRIR 405
            ..:...:  |.|..|  |:             :.|||||: |...:||:...|:..: ..|:.:|
Zfish   340 QHISRDNHTAPPPVKLLGVHFISSEVFFANAYVLAVLLFLALLLQRTFLQASYYVAI-ENGINLR 403

  Fly   406 TALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLW 468
            .|:...||.|.:|:  ||.:..:.|..:|.||:|.|..:.|........:|:.|:||.:.:..|:
Zfish   404 GAVQTKIYNKIMRLCTSNMSMGDMTTAQICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLY 468

  Fly   469 QQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSF 533
            ..||.|.|.|..|:.:|.|:...:|:|:...|...::|..||:|..||:|.|||:|||||||..|
Zfish   469 YLLGASALIGATVITVLAPLQYFVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIF 533

  Fly   534 EKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLV--SIA 596
            ...|.:.|.:|:.:||:.|...:.:.|:.:..|....|..|..:|....::..::...:.  |::
Zfish   534 RSSVEETRRQELTSLRTFALYTSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFGSLS 598

  Fly   597 LFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEEL----DP--------------------- 636
            ||.::..||.:|..:.....:..|||.::::||:|.|:    ||
Zfish   599 LFHILVTPLFLLSSVLHSTVKALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNIKSVYALQLQ 663

  Fly   637 -------NSVLHD-------------SSKPHP----MSIENGEFSWGDEI-TLRNINIEVKKGSL 676
                   |....|             :|..|.    :.|.||.|||.... ||.||:|:|..|.|
Zfish   664 AKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNICIKIVNGYFSWTQGCPTLTNIDIKVPFGQL 728

  Fly   677 VALVGTVGSGKSSVVQAFLGEMEKLAGVV--NTV-----------------------GKLAYVPQ 716
            ..:||.|||||||::.|.||||:|::|.:  |::                       |.:||..|
Zfish   729 TMIVGQVGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSGRQSFTRRGSVAYASQ 793

  Fly   717 QAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEK----GINLSGGQKQ 777
            :.|:.||||.:||||....:.|||..||:.|.|..|||.|..||.|.|||:    ||.|||||:|
Zfish   794 RPWLLNATVEENILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGERVRHLGIILSGGQRQ 858

  Fly   778 RISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGIL-----ARKSRVLVTHGVTFLPQ 837
            |||:|||:|...::..||||.||:|.|:..|:..|     |||     .::|.|||||.:.:||.
Zfish   859 RISVARALYQQTNVVFLDDPFSALDIHLSDHLMHE-----GILKFLRQEKRSVVLVTHKLQYLPH 918

  Fly   838 VDSIYVIKMGEISESGTF-DQLVKNKGAFADFIIQHLQEGNEEEEELNQ--------IKRQISST 893
            .|.|..::.|.:...||. |........|..:.....::..|...||.:        ..|...:|
Zfish   919 ADWIIAMRDGTVQTQGTLKDIQCAEPELFEQWRTLMNRQDKENSTELKRKSFRRAMMYSRDTVAT 983

  Fly   894 ADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQE 958
            .|..|:.......:|        ||.:.|..|||   |..||.||.
Zfish   984 DDEDEVADVAVSEVK--------DSSTSTDEDSL---GAELRHRTT------------------- 1018

  Fly   959 VEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVA- 1022
                           :.::.:..|:|:.|:||....:|......:..:..:.||..|.:|...|
Zfish  1019 ---------------IPWSSFATYLKAAGLFLLPLLIVSQLAKHSLMVAIDFWLAHWTSDVIAAQ 1068

  Fly  1023 ------NDTGLRD------MYLGVY---GAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVI 1072
                  |.|..:|      .||.|:   .|.|.   ||.....:.|...|.:.||.:|..||.:|
Zfish  1069 SESAERNCTFTKDCVFSHSWYLQVFCLLCALGI---VLCLVTSLAVEWTGLRVAKELHCSLLRII 1130

  Fly  1073 IRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIV 1137
            :...: |.|:.||:|.:||.||.|.:.:|:.:|.||:.......:.::.:.|||..||:||..::
Zfish  1131 VLAPM-RLFETTPLGNILNRFSTDTNTIDQHIPVTMECLSRSTLLCVSAVGVISYVTPVFLIALL 1194

  Fly  1138 PIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKN 1202
            |:....||.|:::...||.|.:||..:..|:.||:|:|:.|.:||||:....||.::.....|.|
Zfish  1195 PLTVACYFIQKYFRVASRDLQQLEDSTEMPLLSHYSQTIEGLTTIRAFRHEQRFKKKLLEHTDAN 1259

  Fly  1203 QVCKYPSVIANRWLAIRLEMVGNLIILFASLFAV---LGGQTNPGLVGLSVSYALQVTQTLNWLV 1264
            .:.......|||||.:|:|.:|.|::|.|::.::   |..|.:.|||||.::|||.|:..|||:|
Zfish  1260 NISSLFLTAANRWLEVRMEYIGALVVLIAAVASITNALYRQLSAGLVGLGLTYALMVSNYLNWIV 1324

  Fly  1265 RMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRG 1329
            |..:|:|..:..|:|:.....|:.|:...:......|..||:.|.::.||..|||...|..||:.
Zfish  1325 RNLADMEVQLGCVKRVSGLIHTQPESYDNIMTPAQVPAGWPKYGEIQIQNLSVRYDSSLKPVLKH 1389

  Fly  1330 VSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDP 1394
            ||.:|:.|:||||.||||:||||.:|||||:::...|:|||||:||:.:.|..|||:.:||.|||
Zfish  1390 VSAHIRPGQKVGICGRTGSGKSSFSLALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDP 1454

  Fly  1395 VLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLAR 1459
            :||||::|.||||....||:.:|:|||::.|...||:|..||:..:.|||||.|.|||||.||||
Zfish  1455 ILFSGTIRFNLDPERKATDEMLWEALEIAQLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLAR 1519

  Fly  1460 ALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIE 1524
            |.:||:.:|::|||||::|:.|:.::||.:.|.|.:.||:|||||::|||.||.|||:..|.|||
Zfish  1520 AFVRKSSILIMDEATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIE 1584

  Fly  1525 FASPTELLDNPKSAFYSMAK 1544
            :..|..||:...|.|.:..:
Zfish  1585 YDEPDVLLEQKDSVFSAFVR 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	507/1645 (31%)
		ABC_membrane	338..601	CDD:279056	84/284 (30%)
		ABCC_MRP_domain1	649..848	CDD:213217	99/233 (42%)
		ABC_membrane	988..1260	CDD:279056	92/290 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	117/219 (53%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	473/1442 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650