Protein Alignment MRP and abcc3

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001107301.1
• Gene: abcc3 / 100135090
• XenbaseID: XB-GENE-1003737
• Length: 1531
• Species: Xenopus tropicalis
• Alignment Length: 1573
• Identity: 790/1573 - (50%)
• Similarity: 1062/1573 - (67%)
• Gaps: 76/1573 - (4%)

  Fly     9 MDRFC-----GSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIP 68
            |:.||     ||.||::..|.||::||.||||:.|.|.|.||.:.|..:.|...|||.:....|.
 Frog     1 METFCGSGDLGSQFWDSNLTLYTDNPDVTPCFQNTVLAWIPCVYLWVALPFYLLYLKYNRRGYIV 65

  Fly    69 WNKLNVSKALVNLGLLVITALDLIMA---LVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPL 130
            .:.|:.:|.:..:.|..:...||..:   ||:  ..|..|:|.:.   |:|...|.:...:....
 Frog    66 LSMLSKAKTVFGVLLWCVCWADLFYSFHGLVQ--NQSPPPVYFVT---PLILGITMITATVLAQY 125

  Fly   131 NRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFF 195
            .|..|||::|...|||||.||.:|...|::|...|.:.::.            ::::|.:||::|
 Frog   126 ERLRGVQSSGVLIIFWFLATVCAIIPFRSKVMASARQGQVT------------DKFRFTTFFLYF 178

  Fly   196 TFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDL 260
            :...|.|:|:||.:..|..:..:...|..||..|.||||:|:.||.|||:.||:.|||:||||.|
 Frog   179 SLLVIELLLSCFKEARPFFSPVRDEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSL 243

  Fly   261 RPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEK---------NGRKK 316
            ...|:.:.|:......|    .|...|.|:::  ..:|.......|...||         :.:|.
 Frog   244 NEDDTSNVVVTNLIKEW----EKEKSNLAQMQ--VSYSKKPEAVLNHTDEKAYESDVLIVDNKKP 302

  Fly   317 GMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFV 381
            ...|.:..:.::||..||.|:..|||.|.|:|..||:||::|:|::.:|| |.|.|...|||:|:
 Frog   303 KEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDA-PSWWGFCIAVLMFL 366

  Fly   382 LAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMEL 446
            .:..||.||.|:|...|:.|:|:|:|:...||||:|.|:||.|:.|||||:||||:||||||.:|
 Frog   367 TSLVQTLILHQHFQYCFVTGMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDL 431

  Fly   447 TTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERV 511
            ||:|||:|||||||.||||||||.||||||||:|||::|||:|..||.:.:.:|:.||:|||.|:
 Frog   432 TTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRI 496

  Fly   512 KLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFAT 576
            |||||:|:||||||||||||||.::||:||:||:..|:..|||||.::|.|:.|||||:|.|||.
 Frog   497 KLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAV 561

  Fly   577 YVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLH 641
            ||...|.|.|..||..||::||::::.||.:||.:..::|:..||:.||..||.::|||.|:|..
 Frog   562 YVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFLANDELDLNAVTK 626

  Fly   642 DSSKP-HPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLA 702
            |.:.| :.:::.||.|||   |..| |:|||:.|..|||||:||.||.||||:|.|.||||||..
 Frog   627 DKTLPGNAITVHNGTFSWAKNGGAI-LQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEE 690

  Fly   703 GVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEK 767
            |.|:..|.:|||||||||||.|::||||||:..:.|.|.||::||||..|:::|..||.||||||
 Frog   691 GEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEK 755

  Fly   768 GINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGV 832
            |||||||||||:||||||:|:||:||||||||||||||.||||:.||||.|:|..|:|||||||:
 Frog   756 GINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGI 820

  Fly   833 TFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVP 897
            :||||||.|.|:..|.::|.|::.:|:|..|||::|:..:..:...|||::        :..|..
 Frog   821 SFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDI--------TIPDEE 877

  Fly   898 ELL---GTVEKAIKLARTESLSD--------SISVTSADSLMGGGGSLRRRTKRQDSHDSVASAA 951
            |:|   .|:.....||..|.:::        .||:.|.........:.||.|:::.|.:.||
 Frog   878 EVLLAEETLSTHTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLVA--- 939

  Fly   952 SLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWA 1016
                ||....|||:||.::||.|:..|:..|:|:||:.:||....|.....|..||:|:||:.|.
 Frog   940 ----KQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAISVFICFLYSCQNAAAIGANVWLSDWT 1000

  Fly  1017 NDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFF 1081
            |:..:........|.:|||.|.|..||:|...:...:.:.|..||:.:|:.||...:. :...|:
 Frog  1001 NEPVINQTQQNTQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMH-TPQSFY 1064

  Fly  1082 DITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFA 1146
            |.|||||::|.||.|:.|:||.:|.|:..|:...|..|:|::||..|||:|..||:|:|..|.|.
 Frog  1065 DTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFV 1129

  Fly  1147 QRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVI 1211
            |||||||||||.|||||||||||||||||:||||.||||...:.||..||.|||:||...||.::
 Frog  1130 QRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIV 1194

  Fly  1212 ANRWLAIRLEMVGNLIILFASLFAVLGGQ-TNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIV 1275
            :||||.:|:|.|||.::|||:||||||.: .:|||||||||||||||.:|||:|||:||:|||||
 Frog  1195 SNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIV 1259

  Fly  1276 SVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKV 1340
            :|||:|||.|.:.||||.:| |...|::||.:|.||..|:.||||.||||||:.::..:.|||||
 Frog  1260 AVERVKEYAENETEAPWHIE-DTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKV 1323

  Fly  1341 GIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINL 1405
            ||||||||||||:||.||||:|.|.|.:.||.|:|:.:||..|||||||||||||||||:||:||
 Frog  1324 GIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNL 1388

  Fly  1406 DPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVL 1470
            |||...:|||||||||||:||.||....:.|.:|.:||||||||||||||||||||||||::|:|
 Frog  1389 DPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILIL 1453

  Fly  1471 DEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNP 1535
            ||||||:|||||||||.||||:|::|||||||||||||:|..:|:|||||:|.||.:||.|: ..
 Frog  1454 DEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLI-AL 1517

  Fly  1536 KSAFYSMAKDANL 1548
            |..||.|||||.|
 Frog  1518 KGIFYGMAKDAGL 1530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	786/1561 (50%)
		ABC_membrane	338..601	CDD:279056	155/262 (59%)
		ABCC_MRP_domain1	649..848	CDD:213217	132/201 (66%)
		ABC_membrane	988..1260	CDD:279056	138/272 (51%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	156/219 (71%)
abcc3	NP_001107301.1	MRP_assoc_pro	7..1530	CDD:188098	786/1565 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1002
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68364
Inparanoid	1	1.050	1485	1.000	Inparanoid score	I106
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm48865
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090