DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcb10

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	736	Identity:	191/736 - (25%)
Similarity:	332/736 - (45%)	Gaps:	111/736 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   852 SGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLS 916
            |.|:.:.|:..|:| |..:..:.:|           |.||.              :...|||.|.
Zfish    37 SRTWSRQVRKNGSF-DICVLPVYKG-----------RNISK--------------LSCLRTEGLF 75

  Fly   917 D--------SISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGG 973
            .        ::..||.||     ....:....|:| .:..:|.||....|...||::....|...
Zfish    76 SPKHSRHIVALYSTSTDS-----NQTSKSVVNQES-SAKTTADSLPVPSEDVKKLLQLAHPQRWR 134

  Fly   974 VEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAF 1038
            :..|        ||..:..:|:.::..|...::...::.:  ..:...::.|.|..|..||:...
Zfish   135 LTAA--------VGFLVISSTVTMSAPFFLGKVIDTIYTS--PTEDFSSSLTSLCLMLTGVFLCG 189

  Fly  1039 GFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEE 1103
            |.......|    ::.:.|.|..:.:...|.:.|::..: .|||.|..|.|:|..|.|..:|...
Zfish   190 GAANAARVY----LMQISGQQIVRKLRESLFSSILKQEL-GFFDKTRTGELINRLSADTAIVGRC 249

  Fly  1104 LPATMDSFMTFIFMV---LATIVVISLSTPIF-LAVIVPIAFLYYFAQRFYVATSRQLMRLESVS 1164
            |...:...:..:...   :..::.:|.|...| |.|:.|||.|.....||..:.||:..  ::::
Zfish   250 LTDNLSDGLRSLAQAGAGVGMMLYVSPSLAAFVLMVVPPIACLAVIFGRFLRSISRRTQ--DALA 312

  Fly  1165 RSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDK-NQVCKYPSVIANRWLAIRLEMVGNLII 1228
            .:...:  .|.::...|:||:......:::...|||. .::.|..:|::..:..: ..:.||:||
Zfish   313 EATQLA--EERISNLRTVRAFGKELTEVQKYSQKVDHIFELAKKEAVVSAGFYGV-TGLSGNVII 374

  Fly  1229 LFASLFAVL--GGQTNPGLVGLSVSYALQVTQTLNWLV-------------RMSSDIETNIVSVE 1278
            |     :||  ||.       |..|.|:.|.|..::|:             ...|::...:.:..
Zfish   375 L-----SVLYKGGL-------LMASEAMTVGQLSSFLMYAFWVGISIAGFSSFYSELMKGLGAGT 427

  Fly  1279 RIKEYGETKQEAPWE----LEQDKNKPKNWPQEGRVEFQNFQVRYREGLDL-VLRGVSFNIQGGE 1338
            |:.|..:.|.|.|..    |..:..|       |.:||:|....|....|. :.:.:|.::..|.
Zfish   428 RLWELIDRKPEFPLNEGLVLTSELLK-------GELEFRNVSFAYPTRKDSPIFQDLSLHVPAGS 485

  Fly  1339 KVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRI 1403
            .:.:||.:|:|||||...|.|:.:...|.:|:||.||..:..:.|||.:..:.|:|||||.|:..
Zfish   486 VLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSVDGHDIRDLNPYWLRSHIGTVSQEPVLFSCSIAE 550

  Fly  1404 NL-----DPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLR 1463
            |:     ||.::..:| |::|.::::...|::....|.:..:.|.|..||.||:|.|.:|||||:
Zfish   551 NIAYGAPDPSQVTVED-IYRAAQIANAHDFIQEFPKGYDTVVGEKGVLLSGGQKQRVAIARALLK 614

  Fly  1464 KTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASP 1528
            ..|:|:|||||:|:|.|.:.|:|:.:.......|||.|||||:||..:|.|.|||:.:::|..|.
Zfish   615 NPKILLLDEATSALDAENEFLVQEALERLMDGRTVLIIAHRLSTIQSADSVAVLDQHRVMEIGSH 679

  Fly  1529 TELLDNPKSAFYS-MAKDANL 1548
            ::||.|.:..|.. |.|.|.|
Zfish   680 SQLLANDQGLFRKLMEKQAFL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	190/734 (26%)
		ABC_membrane	338..601	CDD:279056
		ABCC_MRP_domain1	649..848	CDD:213217
		ABC_membrane	988..1260	CDD:279056	60/278 (22%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	83/225 (37%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	164/613 (27%)
		ABC_membrane	141..402	CDD:279056	61/284 (21%)
		P-loop_NTPase	457..697	CDD:304359	88/240 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000