DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcc1

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1570	Identity:	783/1570 - (49%)
Similarity:	1039/1570 - (66%)	Gaps:	83/1570 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MDRFC---GS-TFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRN-IP 68
            :|.||   || ..|:...||.|..||.||||:.|.|||.||.:.|.|......||| |.||. |.
Zfish     3 IDSFCSLDGSDPLWDWNRTWQTYYPDLTPCFQNTVLVWIPCLYLWLFAPLYILYLK-SHDRGYIC 66

  Fly    69 WNKLNVSKALVNLGLLVITALDLIMALVKKG-GDSELPLYDLDVWGPIIKFATFLLLFIFIPLNR 132
            ...||.:|.::...|.:|...|:..:..::. |.:..|:|   :..|.:...|.||....|...|
Zfish    67 MTHLNRAKTVIGFTLWLICWADVFYSFWERSHGATVAPVY---LVSPTMLGVTMLLATFLIQYER 128

  Fly   133 KYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNS-QQPSEQDFSWEEYQFVSFFIFFT 196
            ..|||::|....|| |:|::    |.|    ...|.||::: ..|:    |...:::.:|:|::|
Zfish   129 MKGVQSSGVMLNFW-LITIV----CAT----ITFRSKIMHALNDPA----SVGVFRYTTFYIYYT 180

  Fly   197 FTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLR 261
            ...|.|||.|.:|..|..::..:..|..||..|||||:||:.|...:.:|||:.||||||||.|.
Zfish   181 LLLISLILACLSDQPPLFSEVVKDSNPCPESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLN 245

  Fly   262 PQDSCSEVMPIFAHHWNQNVRKNYK--NKARVEPKAQFSNGNVTFENPHGEKNG----------- 313
            .:|....|:|.....|:|...|..:  :|....||          .:..|||..
Zfish   246 NEDKSERVVPQLVRRWDQECVKVKRPVDKTLYSPK----------RSTRGEKKDGQPVEESEILL 300

  Fly   314 ----RKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGIL 374
                :|.|..|:...:.::||..||..:|.|:..|.|.|..|::|.|:|.||....| |.|.|..
Zfish   301 AKALQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDVLMFVGPEILRLLILFVNDSSA-PTWHGYF 364

  Fly   375 YAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVD 439
            |..||||....||.||.:|||..|:.|:|:|||::.|:|||||.|:|:.::.||||||||||:||
Zfish   365 YTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVD 429

  Fly   440 AQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQM 504
            |||||:|.||:|||||||||:.||||||||.||.|||||:|||::::|:|.|||.:.||||:.||
Zfish   430 AQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQM 494

  Fly   505 KYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV 569
            |.||.|:|||||||:|||||||||||.:|:.:|..||:.|:..|:..|||.|.::|.|.||||||
Zfish   495 KSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLV 559

  Fly   570 SLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEEL 634
            :|.|||.|||..|.|.|..:|..||:|||::::.||.:|||:...:.:..||:.|:..||:.|||
Zfish   560 ALSTFAVYVLVDENNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRLRVFLSHEEL 624

  Fly   635 DPNSVLHD--SSKPHPMSIENGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFL 695
            |.::|...  |..|..:.|.:|.|||.  |..||:.||:.:.:|:|||:||.|||||||::.|.|
Zfish   625 DDDNVERPAISGTPDSIRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALL 689

  Fly   696 GEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGD 760
            |||.|..|.|:..|.:|||||||||||||::||||||:......|.||::||||..|::||..||
Zfish   690 GEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGD 754

  Fly   761 LTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSR 825
            .|||||||:|||||||||:|:|||||.:..:||||||||||||||||||||:||||:|:|..::|
Zfish   755 TTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTR 819

  Fly   826 VLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQI 890
            ||||||::||||.|.|.|:..|||:|.|::.:|:..:||||:|:..:.....||.||
Zfish   820 VLVTHGLSFLPQADLILVMVDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEE-------- 876

  Fly   891 SSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKK 955
             |..|.....| :|.....|.......|::.|       |.|...::|:..|      .||:.|.
Zfish   877 -SLGDAVPRKG-LENGGPAALLRQSQISLNAT-------GAGKTTQKTEAND------DAAATKT 926

  Fly   956 KQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQN 1020
            |.....:|.|.:|:.||.|:.:|:..|:|::|:.||:.::.|.|......:|||.||:.|.:|..
Zfish   927 KSAEASRLTEADKANTGRVKLSVFWEYMKAIGLPLSIFSIFLFFCHHLSSLGSNYWLSLWTDDPV 991

  Fly  1021 VANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITP 1085
            |.|....|:|.||||||.|..||:..:...|.|.:||..|::.:|..:|..::| |...||:.||
Zfish   992 VNNTQPKREMRLGVYGALGISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLR-SPMSFFERTP 1055

  Fly  1086 IGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFY 1150
            .|.|:|.|:.:.|.:|..:|:.:..||..:|.||.:..||.::||:...:|.|:..||:|.||||
Zfish  1056 SGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFY 1120

  Fly  1151 VATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRW 1215
            ||:|||:.|||||||||:|:||:||:.|.|.|||:....|||:|||.:||.||...:||::||||
Zfish  1121 VASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRW 1185

  Fly  1216 LAIRLEMVGNLIILFASLFAVLG-GQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVER 1279
            ||:|||.|||.|:.||:||||:. ...:||::|||:|||||||.:|||||||||::|||||:|||
Zfish  1186 LAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVER 1250

  Fly  1280 IKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVG 1344
            :||||:|::||.|:|| :.|.|..||..|.:|...|.:||||.|:|.:..:|.||.|||||||||
Zfish  1251 VKEYGDTEKEAEWKLE-NSNLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGEKVGIVG 1314

  Fly  1345 RTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFE 1409
            |||||||||||.||||||||.|.|.||||:||.:|||.||||:|||||||||||||||:|||||:
Zfish  1315 RTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMNLDPFD 1379

  Fly  1410 IKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEAT 1474
            ..||:|:|::|||:|||:||..|...||||.:|||||||:|||||||||||||||||:|||||||
Zfish  1380 GYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEAT 1444

  Fly  1475 AAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            ||||||||:|||.||||:|::|||||||||||||:|..:|:||||||:.||.||:.|:.. |..|
Zfish  1445 AAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAK-KGIF 1508

  Fly  1540 YSMAKDANLV 1549
            |.||||:.||
Zfish  1509 YKMAKDSGLV 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	778/1559 (50%)
		ABC_membrane	338..601	CDD:279056	155/262 (59%)
		ABCC_MRP_domain1	649..848	CDD:213217	125/200 (63%)
		ABC_membrane	988..1260	CDD:279056	129/272 (47%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	162/219 (74%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	779/1563 (50%)
		ABC_membrane	331..595	CDD:279056	154/264 (58%)
		ABCC_MRP_domain1	641..842	CDD:213217	125/200 (63%)
		ABC_membrane	966..1231	CDD:279056	127/265 (48%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	162/219 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585968
Domainoid	1	1.000	343	1.000	Domainoid score	I1039
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1486	1.000	Inparanoid score	I105
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm24337
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	LDO	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910