DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pih1D1 and DNAAF2

DIOPT Version :9

Sequence 1:	NP_723771.4	Gene:	Pih1D1 / 34685	FlyBaseID:	FBgn0032455	Length:	1094	Species:	Drosophila melanogaster
Sequence 2:	NP_060609.2	Gene:	DNAAF2 / 55172	HGNCID:	20188	Length:	837	Species:	Homo sapiens

Alignment Length:	402	Identity:	77/402 - (19%)
Similarity:	125/402 - (31%)	Gaps:	138/402 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 EGIRRQFDPELDRRNLNDNFNQRNNYSRGGDTVR------FPRREDDTFQGSNNPNFPPNYPNTI 633
            |.:.:||..:|||||.. ....:...:.....:|      .|.|.|...:|. .|:||  ||
Human   170 EAVEKQFGVKLDRRNAK-TLKAKYKGTPEAAVLRTPLPGVIPARPDGEPKGP-LPDFP--YP--- 227

  Fly   634 LRGSGSGNRCRDTSSNRPMGPNQNRRSRLPNADEAAPSVAHSGGPIQDGTNLNRRINKNLNPGKG 698
                          ...|..|.    .|.|:..|||                       |.|
Human   228 --------------YQYPAAPG----PRAPSPPEAA-----------------------LQP--- 248

  Fly   699 PDRINAGTPNQPRSKSTTSQ---------TRNLNPD-IPNKMVKKSAVP---------------- 737
                   .|.:||.......         :|:..|. :|:::|....:|
Human   249 -------APTEPRYSVVQRHHVDLQDYRCSRDSAPSPVPHELVITIELPLLRSAEQAALEVTRKL 306

  Fly   738 --QDNRAP----QPNKPMNTNPGASKPGQSVIKPKLQAT---KINAAMAKPLAGIKRKA--ETTP 791
              .|:|.|    :.:.|...:.|..|...:..:.:|..|   .:.||..:|...:...|  |:..
Human   307 LCLDSRKPDYRLRLSLPYPVDDGRGKAQFNKARRQLVVTLPVVLPAARREPAVAVAAAAPEESAD 371

  Fly   792 KLG--GAT-------KAGPKRQRADRTDRSFIIGG-------------ISLPYINSNTKKLPQPE 834
            :.|  |..       :|||.|.||:.......:.|             ::.|...:..:::|:|.
Human   372 RSGTDGQACASAREGEAGPARSRAEDGGHDTCVAGAAGSGVTTLGDPEVAPPPAAAGEERVPKPG 436

  Fly   835 EQSYAVTFFEQTPNYNTNIYAIDDGHVDEDEGDGDDEEMSDAESLDSNRSGVLSKWKGRSSKK-- 897
            ||.  ::....:|          .|.|:|....|::..........|:||.......||.|.:
Human   437 EQD--LSRHAGSP----------PGSVEEPSPGGENSPGGGGSPCLSSRSLAWGSSAGRESARGD 489

  Fly   898 -KVRTQLRKEWT 908
             .|.|:...|.|
Human   490 SSVETREESEGT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pih1D1	NP_723771.4	PHA02896	<406..620	CDD:165222	12/50 (24%)
DNAAF2	NP_060609.2	PIH1	43..348	CDD:285409	43/235 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..224		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..249		9/55 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..515		31/151 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4356
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4625
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930