DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pih1D1 and CG5787

DIOPT Version :9

Sequence 1:	NP_723771.4	Gene:	Pih1D1 / 34685	FlyBaseID:	FBgn0032455	Length:	1094	Species:	Drosophila melanogaster
Sequence 2:	NP_001260422.1	Gene:	CG5787 / 34684	FlyBaseID:	FBgn0032454	Length:	950	Species:	Drosophila melanogaster

Alignment Length:	959	Identity:	275/959 - (28%)
Similarity:	384/959 - (40%)	Gaps:	241/959 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 NRNQNPQ--DFNRPNRNQNPQDFNRNNRNAYPHEFNRNIRNDNEQE-FNHNRN-AVNDEFNRNTR 354
            |||.:|.  :|:|...|.: .:.|....|:||..      .|.::. ||.:.| ...|.|....|
  Fly    74 NRNTSPDGGNFSRGGGNYS-NNSNSGGNNSYPRS------GDGDRSGFNPSSNQRFGDNFQDKFR 131

  Fly   355 NVNNQAFPQGHNHNNRNANAQFN-------RKTFDENPNFNNQRFQGPNHQINYRVQMPNNDHSQ 412
            ...:..|.|.    ||.|:.|.|       ....|.||:            :|||...|.....:
  Fly   132 GGPSSNFGQA----NRGASNQSNVARLLEVENRMDCNPD------------VNYRGPQPQGSGDR 180

  Fly   413 VNNNRRPGNQ----NFVSNQ-QPNLDRNAISDDGIQLPRDRFRS-PEAHPKQPPYPRNVNADQVG 471
            ..|: .|.||    |||.|. .|....||.|..|...|.....| |.......|:.        |
  Fly   181 FFND-EPRNQGSFGNFVPNDGVPFGGNNAPSFGGNNGPAYGGNSGPSFGGSDVPFG--------G 236

  Fly   472 NRGPQKRHNYQRIVNDNQIILRRTDWTDEEEDLDLEHHDIDDY--IPDEREFLEDDADFIDDTND 534
            |.||....|.||..|::....|..::.|:....:      |.|  ..:...|.::..:|.|:..|
  Fly   237 NSGPSFGGNNQRNFNNDNFPNRGPNYDDQRSGFN------DSYGRSGNHGNFGQNSGNFGDNNRD 295

  Fly   535 TLMNDDQYEGYHSRGNQHYIQDHNIDDRNSYGRNRNDRNFEGIRRQFDPELDRRNLNDNFNQRNN 599
            ....:::.......|...:    |.:...::|.|.:...|.....|     :..|..||.....|
  Fly   296 IGNFNNRGPAVGGSGGPGF----NPNSGGNFGSNNSGGGFSNNFGQ-----NSGNFGDNNRDIGN 351

  Fly   600 YSRGGDTVRFPRREDDTFQGSNNPNFPPN-------------YPNTILR---------------- 635
            ::..|..|          .||..|.|.||             :.|.|.|
  Fly   352 FNNRGPAV----------GGSGGPGFKPNSGGNFGNNNSGGGFSNNISRTFQDSRNNWNKSQSSS 406

  Fly   636 -------------------------------------GSG--SGNRCRDTSSN--RPMGPNQNRR 659
                                                 |||  :|.|..::..|  :.|..|.:..
  Fly   407 FQNSGYQSNSGGGGGGGGRSGGGGGGGAGGGGGVGSGGSGWEAGQRAFNSKRNQLQKMNLNNSGS 471

  Fly   660 SRLPNADEAAPSVAH-------------SGGPIQDGTNLNRRINKNLNPGKG---PDRINAGTPN 708
            .|.|....||.:|.:             :|.|     .|......||.||..   ..::....||
  Fly   472 VRKPAPQPAAKAVQNLRNNPQKAEIVKSAGAP-----TLRNNKTANLRPGNATGVQKKLPVAAPN 531

  Fly   709 Q-------PRSKSTTSQTRNLNPDIPNKMVKKSAVPQDNR-APQ-----PN------KPMNTNPG 754
            |       |.|| |.|.| |..|.:....||..  ||.|| .||     |.      :.:.:.|.
  Fly   532 QYKVNNVTPNSK-TVSVT-NKKPPVAAPAVKTG--PQANRTGPQGLRTGPQGLRAGPQGLRSGPQ 592

  Fly   755 ASKPGQSVIK--PKL------------QATKINAAMAKPLAGI----------------KRKAET 789
            ..:.||..:|  |:|            ||.|......|| ||:                ||.|..
  Fly   593 GLRTGQQGLKTGPQLQKSGPLAPRTGQQAVKGGPQGGKP-AGVPSRPPNAPGFPVQISQKRVAPP 656

  Fly   790 TPKLGGATKAGPKRQRADRTDRSFIIGGISLPYINSNTKKLPQPEEQSYAVTFFEQTPNYNTNIY 854
            .|....|.....|:.|.....|.|:|||..:||:|...|||||||..|||:||||||.||:||..
  Fly   657 PPLETEAASKSVKKWRRVARKRGFLIGGFKIPYLNDQPKKLPQPEADSYALTFFEQTFNYSTNQD 721

  Fly   855 AIDDGHVDE----DEGDGDDEEMSDAESLDSNRSGVLSKWKGRSSKKKVRTQLRKEWTKIYRTNN 915
            |.::..|:.    :|...|:....||:|             .|...|:.|.::|.:|..:..:..
  Fly   722 ATEEDFVEAAVVLNEDSEDESVADDAKS-------------ARKIAKRNRKRIRSDWAPLNESKK 773

  Fly   916 YKDWHAWWRDFKWCGSEINKKLEKFGDRNLRHRFAPIGRKPMTGKTINQIFKSGHMGLEKNTFSH 980
            |.||..||:|:|..|.||:::|.:.|:.||.|.|.|...|..|.:.:..|.||.|.|||||....
  Fly   774 YNDWGNWWKDYKNVGEEIDQQLLECGNLNLEHCFLPNLPKLTTEQVVYAIIKSAHFGLEKNADVP 838

  Fly   981 YRNMRSIFLLMNEKFLNSLSDEQLEQLQDLIRGVPNHLWLYKIRSMVYLWERYHGTLKTHSANNF 1045
            |..|::||.|||..||::|::..:.::||:|||:||.||:||:||||:||.:|...  |:|.:..
  Fly   839 YDTMKTIFTLMNRTFLDNLTELNMVEIQDIIRGIPNDLWVYKLRSMVFLWAKYKAI--TNSKSTA 901

  Fly  1046 KSD-KEIQSIAREWKSPVFHWLAKQAFDELKAISEIAWPDHKKIYPGLK 1093
            :.| |:.|:||||||||.||||||||||||.||||..|.||:.::|.::
  Fly   902 EDDVKDQQAIAREWKSPCFHWLAKQAFDELVAISETEWKDHRTVFPSIE 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pih1D1	NP_723771.4	PHA02896	<406..620	CDD:165222	46/221 (21%)
CG5787	NP_001260422.1	COG5651	<187..354	CDD:227938	41/189 (22%)
CG5787	NP_001260422.1	PHA03247	<474..667	CDD:223021	49/202 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0019430
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930