Protein Alignment CG5776 and PEX1

DIOPT Version :10

• Sequence 1: NP_609585.1
• Gene: CG5776 / 34680
• FlyBaseID: FBgn0032450
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_012724.1
• Gene: PEX1 / 853636
• SGDID: S000001680
• Length: 1043
• Species: Saccharomyces cerevisiae
• Alignment Length: 883
• Identity: 200/883 - (22%)
• Similarity: 378/883 - (42%)
• Gaps: 206/883 - (23%)

  Fly    33 EGLCFAISQDDVGPDSEAEYVRSGAIYTRSLQQRNFEVESLKDLPTKYANM-LVFVSEGAMQLAQ 96
            ||:......|.|.|..::..:..|::...:.     :|...:.:..:|.:. ...:..||:||.
Yeast   153 EGIVTKFKIDRVEPSMKSARITDGSLVVVAP-----KVNKTRLVKAEYGHSNKTILKNGAIQLL- 211

  Fly    97 LHIGQHVVLEAPSTAEQPLVRIVWPTSEQFLTTVFVSEGDFKLHCTQLRGKLLKISALHPSRLTA 161
                :.|:|.:      .:.::.:|....|:  |::|:|      .||           ||:...
Yeast   212 ----KKVILRS------TVCKMDFPKDNLFV--VYISDG------AQL-----------PSQKGY 247

  Fly   162 AASI--SLKHVNTTETSLKSV--------------------------QLQDA------------I 186
            |:.:  ||:....:::..|||                          .|.||            :
Yeast   248 ASIVKCSLRQSKKSDSDNKSVGIPSKKIGVFIKCDSQIPENHIALSSHLWDAFFTHPMNGAKIKL 312

  Fly   187 ALLKRDMVNRVFYKDSLIHMNFFNKSLTFR--------------------------LERWQSTVE 225
            ..|:.:..|.:..:::.:::.:|.|.:..:                          :|..:...|
Yeast   313 EFLQMNQANIISGRNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNNLILPTEQIIIEIKKGESE 377

  Fly   226 EALAGLS-LDSKPLQFIQVTNVTKLHLITDDANQQEEEQKISHRITK----CQIGGLDRQLQ--- 282
            :.|..|: :.::.:|: :||.:.|          :|.:..|...:.|    .:.|.:.|..:
Yeast   378 QQLCNLNEISNESVQW-KVTQMGK----------EEVKDIIERHLPKHYHVKETGEVSRTSKDED 431

  Fly   283 -------LVEESMEYALGFRTLPAGLRVSRGLLLYGATGCGKSMVLEAMCAVAEERSQGHVQLIR 340
                   :.:|.:.|      |.:.:..:..::|.|..|.||:.:|:.:  :.|.....|
Yeast   432 DFITVNSIKKEMVNY------LTSPIIATPAIILDGKQGIGKTRLLKEL--INEVEKDHH----- 483

  Fly   341 INSGEVYSKF-----LGETE-----QKLGAIFE-RAYNHYPHPTLLLIEDVHNLCPKQE------ 388
                 ::.|:     |.||.     |||  |.| .::.::..|:|:::::|..|..|.:
Yeast   484 -----IFVKYADCETLHETSNLDKTQKL--IMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDP 541

  Fly   389 -NSDLVKRVSLAFLSLLDQLSSPSQLKGSKTFVLATSSQIDTLHPSIRRAGRLDNEVELGAPSSQ 452
             |:......|......::|::........:..||.:..|...::|.:.....:.....|.||...
Yeast   542 SNNGQWDNASKLLNFFINQVTKIFNKDNKRIRVLFSGKQKTQINPLLFDKHFVSETWSLRAPDKH 606

  Fly   453 ARLEIVRCLIK-------SVEHQLSDEEVEHVASITHGYVGADL----ANLVYAAMLQAQ-PNPL 505
            ||.:::.....       :.:.|.||..:|     |.|:...||    ..:.|...|:.. .|.:
Yeast   607 ARAKLLEYFFSKNQIMKLNRDLQFSDLSLE-----TEGFSPLDLEIFTEKIFYDLQLERDCDNVV 666

  Fly   506 QMPHLQAALTRIKPSAMREV-LIECPNVQWSDIGGQSELRLAMQQAIEWPLLHADKFQRLGIKPP 569
            .......:|:...|||:|.| |.:..|::|.|||..:..:..:.:.:|||..:...|....::..
Yeast   667 TRELFSKSLSAFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLR 731

  Fly   570 RGILMFGPPGCSKTMIAKALATESKLNFLSIKGPELFSMWVGESERAVREVFRKARQVAPAIVFF 634
            .|||::|.|||.||::|.|:|.:..|||:|:||||:.:.::|.||:.:||:|.:|:.|.|.|:||
Yeast   732 SGILLYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFF 796

  Fly   635 DEIDAIGGERSEGDGSSSGSSVKERVLTQLLTELDGVEALQNVTIVAATNRPDMIDKALLRPGRI 699
            ||.|:|..:|..   .|:|  |.:||:.||||::||.|.|..|.|:|||:|||:||.|||||||:
Yeast   797 DEFDSIAPKRGH---DSTG--VTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRL 856

  Fly   700 DRILYVGLPQCEARREILKIKL---------RAMPISNDVDMEKLVQLTEGYSGAEIQAVCHEAA 755
            |:.:...:|....|.:||:..:         :...:..:.|::.:.:.|.|:|||::|.:|:.|.
Yeast   857 DKSVICNIPTESERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAY 921

  Fly   756 LRALEQSFEAEDVKWTDFEHALKAVPPRTSPELLKLYE 793
            |:::.        :|.......:.||...:.|...:.|
Yeast   922 LKSVH--------RWLSAADQSEVVPGNDNIEYFSINE 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5776	NP_609585.1	CDC48	183..797	CDD:273521	170/704 (24%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:462729	6/29 (21%)
		CDC48	<401..1023	CDD:273521	156/589 (26%)
		RecA-like_PEX1_r2	705..862	CDD:410934	72/161 (45%)