DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5776 and Nvl

DIOPT Version :10

Sequence 1:NP_609585.1 Gene:CG5776 / 34680 FlyBaseID:FBgn0032450 Length:799 Species:Drosophila melanogaster
Sequence 2:NP_080447.1 Gene:Nvl / 67459 MGIID:1914709 Length:855 Species:Mus musculus


Alignment Length:621 Identity:219/621 - (35%)
Similarity:339/621 - (54%) Gaps:108/621 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   262 EQKISHRITKCQI--------GGLDRQLQLVEE---SMEYALGFRTLPAGLRVSRGLLLYGATGC 315
            ::|...|.|:.||        ||.|..|:.|.:   .|.:...::.|  |:...||:||:|..||
Mouse   246 QKKAKARSTELQISNVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHL--GVVPPRGVLLHGPPGC 308

  Fly   316 GKSMVLEAMCAVAEERSQGHVQLIRINSGEVYSKFLGETEQKLGAIFERAYNHYPHPTLLLIEDV 380
            ||:::..|:....:      :.::::.:.|:.|...||:||||..:|::|.::  .|.::.|:::
Mouse   309 GKTLLAHAIAGELD------LPILKVAAPEIVSGVSGESEQKLRELFDQAVSN--APCIVFIDEI 365

  Fly   381 HNLCPKQE--NSDLVKRVSLAFLSLLDQLSSPSQLKGSKTFVLATSSQIDTLHPSIRRAGRLDNE 443
            ..:.||:|  :.|:.:|:....|:.:|.|::.:..  ::..|:..:::.|:|.|::|||||.|.|
Mouse   366 DAITPKREVASKDMERRIVAQLLTCMDDLNNVAAT--ARVLVIGATNRPDSLDPALRRAGRFDRE 428

  Fly   444 VELGAPSSQARLEIVRCLIKSVEHQLSDE-EVEHVASITHGYVGADLANLV-YAAM--------- 497
            |.||.|...||..|::.|.:.:  :|.:. ...|:|.:|.|:|||||..|. .|||         
Mouse   429 VCLGIPDEAARERILQTLCRKL--RLPETFNFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMK 491

  Fly   498 -----------------------LQAQP------------------NPLQMPHLQ---------- 511
                                   |.|:|                  :||....:|          
Mouse   492 QQAQQKKKPEIEGLPSEGDQEERLGAEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFI 556

  Fly   512 AALTRIKPSAMREVLIECPNVQWSDIGGQSELRLAMQQAIEWPLLHADKFQRLGIKPPRGILMFG 576
            .||..::|||.||..:..|||.|:|||...::|..:..||..|:.:.|:|:.||:..|.|||:.|
Mouse   557 VALAEVQPSAKREGFVTVPNVTWADIGALEDIRDELIMAILAPVRNPDQFRTLGLGTPAGILLAG 621

  Fly   577 PPGCSKTMIAKALATESKLNFLSIKGPELFSMWVGESERAVREVFRKARQVAPAIVFFDEIDAIG 641
            ||||.||::|||:|.||.|||:|:|||||.:|:|||||||||:||::|:..||.::||||:||:.
Mouse   622 PPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 686

  Fly   642 GERSEGDGSSSGSSVKERVLTQLLTELDGVEALQNVTIVAATNRPDMIDKALLRPGRIDRILYVG 706
            ..||:.:   :|:||  ||:.|||||:||:|..|.|.|:|||||||:||.|:|||||:|:.|:||
Mouse   687 PRRSDRE---TGASV--RVVNQLLTEMDGLETRQQVFILAATNRPDIIDPAILRPGRLDKTLFVG 746

  Fly   707 LPQCEARREILKIKLR---AMPISNDVDMEKLVQ--LTEGYSGAEIQAVCHEAALRALEQSFEAE 766
            ||....|..|||...:   ..|:..||::|.:..  ....|:||::.|:..||:|.||.|...|:
Mouse   747 LPPPADRVAILKTITKNGTKPPLDEDVNLETIANDLRCNCYTGADLTALVREASLCALRQEITAQ 811

  Fly   767 ---------DVKWTDFEHALKAVPPRTSPELLKLYE 793
                     .|....||.|.|.|.|..|.:...:||
Mouse   812 KNGVGAGELKVSHKHFEDAFKKVKPSISIKDQVMYE 847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5776NP_609585.1 CDC48 183..797 CDD:273521 219/621 (35%)
NvlNP_080447.1 Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381 1..219
Nucleolin_bd 2..72 CDD:465247
Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449 49..52
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..234
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381 85..88
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381 217..231
CDC48 <242..855 CDD:273521 219/621 (35%)
Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381 266..473 65/220 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..523 3/26 (12%)
Blue background indicates that the domain is not in the aligned region.

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