Protein Alignment CG5776 and PEX1

DIOPT Version :10

• Sequence 1: NP_609585.1
• Gene: CG5776 / 34680
• FlyBaseID: FBgn0032450
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 230/845 - (27%)
• Similarity: 397/845 - (46%)
• Gaps: 133/845 - (15%)

  Fly     6 SSKKNQVTWYHCE-SCGVHIPSKA--RDNHEGLCFAISQDDVGPDSEAEYVRSGAIYTRSLQQRN 67
            |.||.:.:|...| :...::.||.  .||...:|.:.........:.:.:.:..||:.....|..
Human   257 SEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEY 321

  Fly    68 FEVESLKDLPTKYANMLVFVSEGAMQLAQLHIGQHVVL-EAPSTAEQPL---------------- 115
            |:||  ......|..::..:|.   :..|....|:|:. |......:||
Human   322 FDVE--PSFTVTYGKLVKLLSP---KQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKA 381

  Fly   116 --VRIVWPTSEQFLTTVFVSEGDFKLHC------TQLRGKLLKISALHPSRLTAAASISLKHVNT 172
              :::||...|:....:..::....||.      ..||.:|         .:...|.:.:..|..
Human   382 CVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRL---------NIEMHAVVRITPVEV 437

  Fly   173 TETSLKSVQLQDAIAL---LKRDMVNRVFY-------------------------KDSLIHMNFF 209
            |....:|::||....|   :..:.:..|||                         ||.|   ..|
Human   438 TPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGL---KEF 499

  Fly   210 NKSLTFRLERWQSTVEEALAGLSLDSKPLQFIQVTNVTKLHLITDDANQQEEEQKISHRITKCQI 274
            :.|:   :..|:...::.:..||.:        :...|.:.::.|...::|..::|...:...::
Human   500 SLSI---VHSWEKEKDKNIFLLSPN--------LLQKTTIQVLLDPMVKEENSEEIDFILPFLKL 553

  Fly   275 GGLDRQLQLVEESMEY----ALG------FRTLPAGLRVSRGLLLYGATGCGKSMVLEAMCAVAE 329
            ..|.....|...|:|:    .||      ..:|.|||| :..|||.|..|.|||.:.:|:|..|.
Human   554 SSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLR-NGALLLTGGKGSGKSTLAKAICKEAF 617

  Fly   330 ERSQGHVQLIRINSGEVYSKFLGETEQKLGAIFERAYNHYPHPTLLLIEDVHNLC-----PKQEN 389
            ::...||:  |::...:..|.|...::.|...|..|.  :..|:::|::|:..:.     |:.|:
Human   618 DKLDAHVE--RVDCKALRGKRLENIQKTLEVAFSEAV--WMQPSVVLLDDLDLIAGLPAVPEHEH 678

  Fly   390 S-DLV--KRVSLAFLSLLDQLSSPSQLKGSKTFVLATSSQIDTLHP---SIRRAGRLDNEVELGA 448
            | |.|  :|::.|...::.:..|    .||...::|||....:|||   |.:..........:..
Human   679 SPDAVQSQRLAHALNDMIKEFIS----MGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQP 739

  Fly   449 PSSQARLEIVRCLIKSV----EHQLSDEEVEHVASITHGYVGADLANLVYAAM---LQAQP---- 502
            |:.:.|.||:..:||:.    .::.:|.:::|||..|.|:|..|...||..|:   |..|.
Human   740 PNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTR 804

  Fly   503 NPLQMPHL--QAALTRIKPSAMREVLIECP-NVQWSDIGGQSELRLAMQQAIEWPLLHADKFQRL 564
            ..|.:..|  |.||....|:::|.|.:..| ::.|..|||..|:|..:...|:.|..:.:.|..|
Human   805 EKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANL 869

  Fly   565 GIKPPRGILMFGPPGCSKTMIAKALATESKLNFLSIKGPELFSMWVGESERAVREVFRKARQVAP 629
            .|:...|||::||||..||::|..:|.||::||:|:|||||.|.::|.||:|||::|.:|:...|
Human   870 PIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKP 934

  Fly   630 AIVFFDEIDAIGGERSEGDGSSSGSSVKERVLTQLLTELDGVEALQNVTIVAATNRPDMIDKALL 694
            .|:||||.::|...|..     ..:.|.:||:.||||:|||||.||.|.::|||:|||:||.|||
Human   935 CILFFDEFESIAPRRGH-----DNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALL 994

  Fly   695 RPGRIDRILYVGLPQCEARREILKIKLRAMPISNDVDMEKLVQLTEGYSGAEIQAVCHEAALRAL 759
            ||||:|:.:|...|...:|.|||.:...::|:::|||::.:..:|:.::||:::|:.:.|.|.||
Human   995 RPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059

  Fly   760  759
            Human  1060  1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5776	NP_609585.1	CDC48	183..797	CDD:273521	193/640 (30%)
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		5/20 (25%)
		CDC48	<595..1065	CDD:273521	165/478 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283