Protein Alignment CG5776 and NVL

DIOPT Version :10

• Sequence 1: NP_609585.1
• Gene: CG5776 / 34680
• FlyBaseID: FBgn0032450
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 233/719 - (32%)
• Similarity: 363/719 - (50%)
• Gaps: 152/719 - (21%)

  Fly   181 QLQDA--IALLKRDMVNRVFYKDSLIHMNFFNKSLTFRLERWQSTVEEALAGLSLDSKP--LQFI 241
            ::||:  .:||:.||..:...|         ||....:.|..|....|..|.|...:|.  |:|
Human   237 EIQDSKDSSLLESDMKRKGKLK---------NKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEF- 291

  Fly   242 QVTNVTKLHLITDDANQQEEEQKISHRITKCQIGGLDRQLQLVEE---SMEYALGFRTLPAGLRV 303
            |::||                 |..      .:||.|..|:.|.:   .|.:...:..|  |:..
Human   292 QISNV-----------------KFE------DVGGNDMTLKEVCKMLIHMRHPEVYHHL--GVVP 331

  Fly   304 SRGLLLYGATGCGKSMVLEAMCAV---------------------AEERSQGHVQLIRINSGEVY 347
            .||:||:|..||||:::..|:...                     |....:..:.::::.:.|:.
Human   332 PRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPEIV 396

  Fly   348 SKFLGETEQKLGAIFERAYNHYPHPTLLLIEDVHNLCPKQE--NSDLVKRVSLAFLSLLDQLSSP 410
            |...||:||||..:||:|.::  .|.::.|:::..:.||:|  :.|:.:|:....|:.:|.|::.
Human   397 SGVSGESEQKLRELFEQAVSN--APCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNV 459

  Fly   411 SQLKGSKTFVLATSSQIDTLHPSIRRAGRLDNEVELGAPSSQARLEIVRCLIKSVE-HQLSDEEV 474
            :..  ::..|:..:::.|:|.|::|||||.|.|:.||.|...:|..|::.|.:.:. .|..|  .
Human   460 AAT--ARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFD--F 520

  Fly   475 EHVASITHGYVGADLANLV-YAAM---------LQAQ---------------------------- 501
            .|:|.:|.|:|||||..|. .|||         ||.|
Human   521 CHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSET 585

  Fly   502 -------------PNPLQMPHLQ----------AALTRIKPSAMREVLIECPNVQWSDIGGQSEL 543
                         .:||....:|          .||:.::|||.||..:..|||.|:|||...::
Human   586 QDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDI 650

  Fly   544 RLAMQQAIEWPLLHADKFQRLGIKPPRGILMFGPPGCSKTMIAKALATESKLNFLSIKGPELFSM 608
            |..:..||..|:.:.|:|:.||:..|.|:|:.|||||.||::|||:|.||.|||:|:|||||.:|
Human   651 REELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM 715

  Fly   609 WVGESERAVREVFRKARQVAPAIVFFDEIDAIGGERSEGDGSSSGSSVKERVLTQLLTELDGVEA 673
            :|||||||||:||::|:..||.::||||:||:...||:.:   :|:||  ||:.|||||:||:||
Human   716 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRE---TGASV--RVVNQLLTEMDGLEA 775

  Fly   674 LQNVTIVAATNRPDMIDKALLRPGRIDRILYVGLPQCEARREILKIKLR---AMPISNDVDMEKL 735
            .|.|.|:|||||||:||.|:|||||:|:.|:||||....|..|||...:   ..|:..||::|.:
Human   776 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAI 840

  Fly   736 V--QLTEGYSGAEIQAVCHEAALRALEQSFEAE---------DVKWTDFEHALKAVPPRTSPELL 789
            .  ...:.|:||::.|:..||::.||.|....:         .|....||.|.|.|....|.:..
Human   841 AGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQ 905

  Fly   790 KLYE 793
            .:||
Human   906 IMYE 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5776	NP_609585.1	CDC48	183..797	CDD:273521	233/717 (32%)
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247
		CDC48	<277..917	CDD:273521	221/670 (33%)