Protein Alignment CG5776 and Spast

DIOPT Version :10

• Sequence 1: NP_609585.1
• Gene: CG5776 / 34680
• FlyBaseID: FBgn0032450
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: XP_008762708.1
• Gene: Spast / 362700
• RGDID: 1308494
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 507
• Identity: 144/507 - (28%)
• Similarity: 237/507 - (46%)
• Gaps: 76/507 - (14%)

  Fly   327 VAEERSQGHVQLIRINSGEVYSKFLGETEQKLGAIFERAYNHYPHPTLLLIEDVHNLCPKQENSD 391
            :.||...|..:    .:.|.|.|.:.|.|:.:..|.......|.....|..:.:.||...::.
  Rat   131 IDEEEKAGQKE----QAVEWYKKGIEELEKGIAVIVTGQGEQYERARRLQAKMMTNLVMAKDR-- 189

  Fly   392 LVKRVSLAFLSLLDQLSSPSQLKGSKTFVLATSSQIDTLHPSIRRAGRLDNEVELGA------PS 450
                     |.||::|....|...|:|.|...|:.:..      |.|.|.:  |.||      |.
  Rat   190 ---------LQLLEKLQPVLQFSKSQTDVYNESTNLTC------RNGHLQS--ESGAVPKKKDPL 237

  Fly   451 SQARLEIVR--CLIKSVEHQLSDE----EVEHVASITHGYVGADLANLVYAAMLQAQPNPLQMPH 509
            :.|...:.|  .::||....||..    ....::.::....|:..|...:..  .::||....|.
  Rat   238 THASNSLPRSKTVMKSGSTGLSGHHRAPSCSGLSMVSGARPGSGPAATTHKG--TSKPNRTNKPS 300

  Fly   510 LQAALTRIKPS--------------AMREVLIECPNVQWSDIGGQSELRLAMQQAIEWPLLHADK 560
            ......|.|..              .|.|::.....|::.||.||...:.|:|:.:..|.|..:.
  Rat   301 TPTTAVRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPEL 365

  Fly   561 FQRLGIK-PPRGILMFGPPGCSKTMIAKALATESKLNFLSIKGPELFSMWVGESERAVREVFRKA 624
            |  .|:: |.||:|:|||||..|||:|||:|.||...|.:|....|.|.:|||.|:.||.:|..|
  Rat   366 F--TGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVA 428

  Fly   625 RQVAPAIVFFDEIDAIGGERSEGDGSSSGSSVKERVLTQLLTELDGVEAL--QNVTIVAATNRPD 687
            |::.|:|:|.||:|::..||.||:..:|     .|:.|:.|.|.|||::.  ..|.::.|||||.
  Rat   429 RELQPSIIFIDEVDSLLCERREGEHDAS-----RRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQ 488

  Fly   688 MIDKALLRPGRIDRILYVGLPQCEARREILKIKL--RAMPISNDVDMEKLVQLTEGYSGAEIQAV 750
            .:|:|:||  |..:.:||.||..|.|..:||..|  :..|::.. ::.:|.::|:||||:::.|:
  Rat   489 ELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGYSGSDLTAL 550

  Fly   751 CHEAALRALEQ----------SFEAEDVKWTDFEHALKAVPPRTSPELLKLY 792
            ..:|||..:.:          :.|..:::.:||..:||.:....||:.|:.|
  Rat   551 AKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAY 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5776	NP_609585.1	CDC48	183..797	CDD:273521	144/507 (28%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142	14/76 (18%)
		RecA-like_spastin	341..504	CDD:410932	70/171 (41%)
		AAA_lid_3	531..585	CDD:465537	13/53 (25%)
		Vps4_C	<578..610	CDD:462762	8/25 (32%)