Protein Alignment CG5776 and Vcp

DIOPT Version :10

• Sequence 1: NP_609585.1
• Gene: CG5776 / 34680
• FlyBaseID: FBgn0032450
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_446316.1
• Gene: Vcp / 116643
• RGDID: 621595
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 821
• Identity: 254/821 - (30%)
• Similarity: 414/821 - (50%)
• Gaps: 140/821 - (17%)

  Fly    45 GPDSEAEYVRSGAIYTRSLQQRNFEVESLKDLPTKYANMLVFVSEGAMQLAQLHIGQHVVLEAPS 109
            |.||:.:     .:.|..|:|:|.....:.|......|.:|.:|:..|...||..|..|:|:...
  Rat     4 GADSKGD-----DLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKK 63

  Fly   110 TAEQPLVRIVWPTSEQFLTTVFVSEGDFKLHCTQ-----LRGKLLKISALHP-------SRLTAA 162
            ..|...:.:...|.           .|.|:...:     ||.:|..:.::.|       .|:
  Rat    64 RREAVCIVLSDDTC-----------SDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRI--- 114

  Fly   163 ASISLKHV------------NTTETSLKSVQLQDAIALLKRDMVNRVFYKDSLIHMNFFNKSLTF 215
                  ||            |..|..||...|:....:.|.|:                     |
  Rat   115 ------HVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDI---------------------F 152

  Fly   216 RLERWQSTVEEALAGLSLDSKPLQFIQVTNVTKLHLITDDANQQEEEQKISHRITKCQIGGLDRQ 280
            .:......||..:    :::.|..:..|...|.:|...:...:::||:.: :.:....|||..:|
  Rat   153 LVRGGMRAVEFKV----VETDPSPYCIVAPDTVIHCEGEPIKREDEEESL-NEVGYDDIGGCRKQ 212

  Fly   281 LQLVEESMEYALGFRTL--PAGLRVSRGLLLYGATGCGKSMVLEAMCAVAEERSQGHVQLIRINS 343
            |..::|.:|..|....|  ..|::..||:||||..|.||:::..   |||.|..   .....||.
  Rat   213 LAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIAR---AVANETG---AFFFLING 271

  Fly   344 GEVYSKFLGETEQKLGAIFERAYNHYPHPTLLLIEDVHNLCPKQE--NSDLVKRVSLAFLSLLDQ 406
            .|:.||..||:|..|...||.|..:  .|.::.|:::..:.||:|  :.::.:|:....|:|:|.
  Rat   272 PEIMSKLAGESESNLRKAFEEAEKN--APAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDG 334

  Fly   407 LSSPSQLKGSKTFVLATSSQIDTLHPSIRRAGRLDNEVELGAPSSQARLEIVRCLIKSVEHQLSD 471
            |...:.:     .|:|.:::.:::.|::||.||.|.||::|.|.:..||||::...|::  :|:|
  Rat   335 LKQRAHV-----IVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNM--KLAD 392

  Fly   472 E-EVEHVASITHGYVGADLANLVYAAMLQAQPNPLQMPHLQA--------------------ALT 515
            : ::|.||:.|||:||||||.|...|.|||....:.:..|:.                    ||:
  Rat   393 DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALS 457

  Fly   516 RIKPSAMREVLIECPNVQWSDIGGQSELRLAMQQAIEWPLLHADKFQRLGIKPPRGILMFGPPGC 580
            :..|||:||.::|.|.|.|.||||..:::..:|:.:::|:.|.|||.:.|:.|.:|:|.:|||||
  Rat   458 QSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGC 522

  Fly   581 SKTMIAKALATESKLNFLSIKGPELFSMWVGESERAVREVFRKARQVAPAIVFFDEIDAIGGERS 645
            .||::|||:|.|.:.||:|||||||.:||.||||..|||:|.||||.||.::||||:|:|.  ::
  Rat   523 GKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIA--KA 585

  Fly   646 EGDGSSSGSSVKERVLTQLLTELDGVEALQNVTIVAATNRPDMIDKALLRPGRIDRILYVGLPQC 710
            .|.....|....:||:.|:|||:||:...:||.|:.||||||:||.|:|||||:|:::|:.||..
  Rat   586 RGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650

  Fly   711 EARREILKIKLRAMPISNDVDMEKLVQLTEGYSGAEIQAVCHEAALRALEQSFEAE--------- 766
            ::|..|||..||..|::.|||:|.|.::|.|:|||::..:|..|...|:.:|.|:|
  Rat   651 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQT 715

  Fly   767 --------------DVKWTDFEHALKAVPPRTSPELLKLYE 793
                          :::...||.|::......|...::.||
  Rat   716 NPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5776	NP_609585.1	CDC48	183..797	CDD:273521	221/659 (34%)
Vcp	NP_446316.1	CDC48	25..764	CDD:273521	247/795 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727		0/18 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250|UniProtKB:P55072	802..806