DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PICK1 and Pick1

DIOPT Version :9

Sequence 1:	NP_001285881.1	Gene:	PICK1 / 34677	FlyBaseID:	FBgn0032447	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_445912.2	Gene:	Pick1 / 84591	RGDID:	69437	Length:	416	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	223/379 - (58%)
Similarity:	283/379 - (74%)	Gaps:	1/379 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELDRLGMTVSTNAVVITKDQSNLIGISIGGGAPMCPCLYIVQIFDGTPAAREGSLQSGDELLAVN 149
            |.|:||:......|.:.||..|||||||||||..||||||||:||.||||.:|::.:|||:..||
  Rat    10 EEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVN 74

  Fly   150 SVSVKGKTKVEVAKMIQTATDEVVIHYNKLHADPEQGKTLDIILKKLKHRIVDNLSSNTADTLGL 214
            ..|:|||||||||||||....||.||||||.|||:||.:|||:|||:|||:|:|:||.|||.|||
  Rat    75 GRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGL 139

  Fly   215 SRAILCNDSLVKRLEELEGTELMYKGLVEHARRMLKAYYDLLQTYKSFGDCFTQISVHEPQQRAS 279
            ||||||||.|||||||||.|..:|||:.||.:.:|:|:|:|.||:::|||.|:.|.|.|||..||
  Rat   140 SRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAAS 204

  Fly   280 EAFRTFGEFHRTLEKDGLGIIKQIKPVLADLGTYLNKAIPDTKLTVRRYADAKFTYLSYCLKVKE 344
            |||..|.:.||::||.|:.::|.|||:|.||.||||||||||:||:::|.|.||.||||||||||
  Rat   205 EAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKE 269

  Fly   345 MDDEEHGFAALQEPLYRVETGNYEYRLILRCRQDARSKFAKLRTDVLEKMELLECKHAMDLNKQL 409
            |||||:...||.||||||.||||||||||||||:||::|:::|.|||||||||:.||..|:..||
  Rat   270 MDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQL 334

  Fly   410 RSLLESLAELHRSLVDRLDSLPPLFPIEVDFKETDFQYKSSTLKPQELDDDEIE 463
            :..:.::::.:......|.. ..:||||||...|...|..:.....:.:|:|.|
  Rat   335 QRFVSTMSKYYNDCYAVLRD-ADVFPIEVDLAHTTLAYGPNQGGFTDGEDEEEE 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PICK1	NP_001285881.1	PDZ_signaling	98..174	CDD:238492	50/75 (67%)
PICK1	NP_001285881.1	BAR_PICK1	221..436	CDD:153343	123/214 (57%)
Pick1	NP_445912.2	PDZ	19..99	CDD:214570	50/79 (63%)
		BAR_PICK1	146..360	CDD:153343	123/214 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..416		3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335315
Domainoid	1	1.000	302	1.000	Domainoid score	I1359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7470
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1574
OMA	1	1.010	-	-		QHG52411
OrthoDB	1	1.010	-	-		D251076at33208
OrthoFinder	1	1.000	-	-		FOG0006414
OrthoInspector	1	1.000	-	-		oto98521
orthoMCL	1	0.900	-	-		OOG6_107729
Panther	1	1.100	-	-	LDO	PTHR12141
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4679
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910