DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PICK1 and pick1

DIOPT Version :9

Sequence 1:	NP_001285881.1	Gene:	PICK1 / 34677	FlyBaseID:	FBgn0032447	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001039225.2	Gene:	pick1 / 734086	XenbaseID:	XB-GENE-959376	Length:	421	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	228/395 - (57%)
Similarity:	291/395 - (73%)	Gaps:	2/395 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SGDRFGIESASRQKYELDRL-GMTVSTNAVVITKDQSNLIGISIGGGAPMCPCLYIVQIFDGTPA 133
            ||..|....:..:...|.|. |:......|.:.||..|:|||||||||..||||||||:||.|||
Frog    10 SGPSFAFSKSQLKTMALRRNGGIPTVPGTVTLKKDSQNVIGISIGGGAQHCPCLYIVQVFDNTPA 74

  Fly   134 AREGSLQSGDELLAVNSVSVKGKTKVEVAKMIQTATDEVVIHYNKLHADPEQGKTLDIILKKLKH 198
            :.:|::.:|||:..||..|||||||||||||||....||.||||||.|||:|||:|||:|||:||
Frog    75 SLDGTIAAGDEITGVNGKSVKGKTKVEVAKMIQNVKGEVTIHYNKLQADPKQGKSLDIVLKKVKH 139

  Fly   199 RIVDNLSSNTADTLGLSRAILCNDSLVKRLEELEGTELMYKGLVEHARRMLKAYYDLLQTYKSFG 263
            |:|:||||.|||.|||||||||||.|||||||||.|...|:|::||.:|:|:::::|.||:::||
Frog   140 RLVENLSSGTADALGLSRAILCNDGLVKRLEELEKTGEFYRGMMEHTKRLLRSFFELSQTHRAFG 204

  Fly   264 DCFTQISVHEPQQRASEAFRTFGEFHRTLEKDGLGIIKQIKPVLADLGTYLNKAIPDTKLTVRRY 328
            |.|:.|.|.|||..|||||..|.:.||::||.|:|::|.|||:|:||.|||||||||||||:|:|
Frog   205 DVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIGLLKTIKPMLSDLNTYLNKAIPDTKLTIRKY 269

  Fly   329 ADAKFTYLSYCLKVKEMDDEEHGFAALQEPLYRVETGNYEYRLILRCRQDARSKFAKLRTDVLEK 393
            .|.||.|||||||||||||||:...||.||||||.||||||||||||||:||::|||:|.|||||
Frog   270 LDVKFEYLSYCLKVKEMDDEEYSSIALGEPLYRVGTGNYEYRLILRCRQEARARFAKMRKDVLEK 334

  Fly   394 MELLECKHAMDLNKQLRSLLESLAELHRSLVDRLDSLPPLFPIEVDFKETDFQYKSSTLKPQELD 458
            :|||:.||..|:..||:..:.::::.:....:.|.. ..:||||||..:|...|.........:|
Frog   335 IELLDQKHVHDIVFQLQRFVSAMSKYNDQCYEVLKE-ADIFPIEVDLAKTTLAYGQGDTFTDGID 398

  Fly   459 DDEIE 463
            ::|.|
Frog   399 EEEEE 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PICK1	NP_001285881.1	PDZ_signaling	98..174	CDD:238492	49/75 (65%)
PICK1	NP_001285881.1	BAR_PICK1	221..436	CDD:153343	125/214 (58%)
pick1	NP_001039225.2	PDZ_signaling	38..115	CDD:238492	49/76 (64%)
pick1	NP_001039225.2	BAR_PICK1	162..376	CDD:153343	125/214 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1371
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7470
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1599
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251076at33208
OrthoFinder	1	1.000	-	-		FOG0006414
OrthoInspector	1	1.000	-	-		oto105212
Panther	1	1.100	-	-	LDO	PTHR12141
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4679
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160