DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PICK1 and Y57G11C.22

DIOPT Version :9

Sequence 1:	NP_001285881.1	Gene:	PICK1 / 34677	FlyBaseID:	FBgn0032447	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001041046.1	Gene:	Y57G11C.22 / 178409	WormBaseID:	WBGene00013317	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	183/462 - (39%)
Similarity:	282/462 - (61%)	Gaps:	49/462 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELDRLGMTVSTNAVVITKDQSNLIGISIGGGAPMCPCLYIVQIFDGTPAAREGSLQSGDELLAVN 149
            |.|||||.:.:..:.:|||:..::|||||||.|.|||:|:||:||.:||.::|.::.|||::|:|
Worm     6 EEDRLGMRIQSETIELTKDEKGVVGISIGGGGPYCPCVYVVQVFDKSPAFKDGRIRCGDEIVAIN 70

  Fly   150 SVSVKGKTKVEVAKMIQTATDEVVIHYNKLHADPEQGKTLDIILKKLKHRIVDNLSSNTADTLGL 214
            .::|||:.|..||::||.:.:.|.|..|||.....:||||||::||:||::|:.:..::||.|||
Worm    71 GITVKGERKSAVAQLIQVSLNPVKITINKLEEANTKGKTLDILIKKVKHKVVEFVDQDSADALGL 135

  Fly   215 SRAILCNDSLVKRLEELEGTELMYKGLVEHARRMLKAYYDLLQTYKSFGDCFTQISVHEPQQRAS 279
            |||||.||.|.::.:.||.....|:.||.:...|.:....:.:..|.||..|..::.||.||.|:
Worm   136 SRAILTNDPLAEKEKILEENAEFYRHLVAYFGDMFQYQQKISECQKEFGSIFCDLAAHEKQQTAN 200

  Fly   280 EAFRTFGEFHRTLEKDGLGIIKQIKPVLADLGTYLNKAIPDTKLTVRRYADAKFTYLSYCLKVKE 344
            |||.:||:.||.:.|........::.:::||..|::..:|||:||:::|.|.|:.|||||||:||
Worm   201 EAFSSFGDKHRMIAKKQSESAVPLQKMVSDLQVYIDHVVPDTRLTIKKYLDVKYEYLSYCLKLKE 265

  Fly   345 MDDEEHGFAALQEPLYRVETGNYEYRLILRCRQDARSKFAKLRTDVLEKMELLECKHAMDLNKQL 409
            |||||..|.|:|||||||||||||||::|||||:.|::|.|:|.||:.|:|||:.||..|:.:.|
Worm   266 MDDEEVEFVAIQEPLYRVETGNYEYRVMLRCRQECRARFMKMRDDVMVKIELLDQKHVRDIAQHL 330

  Fly   410 RSLLESLAELHRS----LVDRLDSLPPLFPIEVDFKETDFQYKSSTLK---PQELDDDEIEANNH 467
            ....:::|:..:.    |.:|:|     .|||:|.::.:....:|..|   .:|:..|.|..|::
Worm   331 AIFAKTMAKCQQECAEILKERID-----VPIEIDLEQLNLNMNTSDGKANGEEEMGQDAIVLNDN 390

  Fly   468 PHSTPSQVDCGFEAVEQPAAIINVEAAKASVDSST--------LQSASENETL----------LK 514
            |             :|.....:|      .:.|||        |:..|:|:|.          |:
Worm   391 P-------------LEGDLIDVN------DIGSSTEFNEPRISLRRDSQNDTSQPLLGAPDSPLE 436

  Fly   515 ELGLYDV 521
            ||.|.|:
Worm   437 ELSLIDI 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PICK1	NP_001285881.1	PDZ_signaling	98..174	CDD:238492	36/75 (48%)
PICK1	NP_001285881.1	BAR_PICK1	221..436	CDD:153343	91/218 (42%)
Y57G11C.22	NP_001041046.1	PDZ_signaling	<39..97	CDD:238492	26/57 (46%)
Y57G11C.22	NP_001041046.1	BAR_PICK1	142..356	CDD:153343	91/218 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156564
Domainoid	1	1.000	217	1.000	Domainoid score	I1550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7470
Inparanoid	1	1.050	342	1.000	Inparanoid score	I1387
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52411
OrthoDB	1	1.010	-	-		D251076at33208
OrthoFinder	1	1.000	-	-		FOG0006414
OrthoInspector	1	1.000	-	-		oto19076
orthoMCL	1	0.900	-	-		OOG6_107729
Panther	1	1.100	-	-	LDO	PTHR12141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3517
SonicParanoid	1	1.000	-	-		X4679
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940