DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and CCT6A

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001753.1	Gene:	CCT6A / 908	HGNCID:	1620	Length:	531	Species:	Homo sapiens

Alignment Length:	541	Identity:	160/541 - (29%)
Similarity:	279/541 - (51%)	Gaps:	36/541 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AAAVNIKPTAKAFKDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGAT 69
            ||...:.|.|:..:.::    ....||.||:.:.|.:||:|||:|..||:.:|.|::.:|.||..
Human     2 AAVKTLNPKAEVARAQA----ALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNV 62

  Fly    70 ILKQMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCS 134
            :|.:|.:.||.|.::.:::.|||...||||||.|:|.|.||:..:..:.:||||..|::.|:...
Human    63 LLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAK 127

  Fly   135 NKAVEILKQMSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLK 199
            .||::.|:::....|: ||||||..|.|||.:||.::.:.:|....||::|.:..  ::..:||.
Human   128 EKALQFLEEVKVSREM-DRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKK--QDEPIDLF 189

  Fly   200 NIKVISSLGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVIVSDYA 264
            .|:::.....:..||.|:.|||....:...:..||:|.|.|......:...||:::.........
Human   190 MIEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAE 254

  Fly   265 AMDRVLKEERSYILNIVKQI---KKSGCN------VLLVQKSILRDAVSDLAQHFLDKIKCMVVK 320
            ..::::|.||.:|.:.||:|   |:..|.      |::.||.|     ...:...|.|...:.::
Human   255 EREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGI-----DPFSLDALSKEGIVALR 314

  Fly   321 DVEREDIEFVCKTLHCRPIA--SLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVSIIC 383
            ..:|.::|.:  ||.|..:|  |.|..:.:.|..|.||.|...|..||..|....| .|:|:::.
Human   315 RAKRRNMERL--TLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNN-PRSVTLLI 376

  Fly   384 RGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFA 448
            :|.||..|.:...::.|.|..|:..:.....:.|.||.|:.||..|.....:|:|......:|||
Human   377 KGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQAFA 441

  Fly   449 DALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKG-----AITDIFAENVVQPLLVS 508
            |||.:||..||:|:|.:...|:.:::..|::..:..|:::..|     |...::....|:..|:.
Human   442 DALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVKKQLLH 506

  Fly   509 ISSITLATETIRSILKIDDIV 529
             |...:||    :||.:|:|:
Human   507 -SCTVIAT----NILLVDEIM 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	156/528 (30%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	151/507 (30%)
CCT6A	NP_001753.1	chap_CCT_zeta	3..530	CDD:274088	159/540 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820