DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and CCT2

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_012124.1	Gene:	CCT2 / 854664	SGDID:	S000001404	Length:	527	Species:	Saccharomyces cerevisiae

Alignment Length:	521	Identity:	167/521 - (32%)
Similarity:	279/521 - (53%)	Gaps:	28/521 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQ-AGNGEVSITNDGATILKQMNVLHPAAKM 83
            :.:..:.|||....|.||.|.::::|||:||||::| |.:....:|||||||||.:.:.:||||:
Yeast    12 EERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAKV 76

  Fly    84 LVELSRAQDVAAGDGTTSVVVIAGALLEACEKLL-QKGLHPTAISDSFQRCSNKAVEILKQMSTP 147
            ||.:|:.||...|||||||.|::..||...|||: |..:||..|.:.::..|..|::.|.:.:..
Yeast    77 LVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVD 141

  Fly   148 IELDD---RETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLGG 209
            ...|.   ||.||..|.|:|:||::||.....|.:|.:|:|::     :.|.:|::|::|..|||
Yeast   142 NSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRL-----KGSTNLEHIQIIKILGG 201

  Fly   210 TVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVI------VSDYAAMDR 268
            .:.|:.|.:|.:. .:..|:|.|||||.|||     .|:....|.|...|      |...|.:.:
Yeast   202 KLSDSFLDEGFIL-AKKFGNNQPKRIENAKI-----LIANTTLDTDKVKIFGTKFKVDSTAKLAQ 260

  Fly   269 VLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCKT 333
            :.|.||..:.|.:.:|.|.|.|..     |.|..:.|..:.....:....::..:.|.:|.:...
Yeast   261 LEKAEREKMKNKIAKISKFGINTF-----INRQLIYDYPEQLFTDLGINSIEHADFEGVERLALV 320

  Fly   334 LHCRPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVSIICRGSNKLVLEEAARSL 398
            .....:::.|..:...|...|::||:..|...|:|.:|.: .|...:|:.||:....|:||.|||
Yeast   321 TGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCK-AGEACTIVLRGATDQTLDEAERSL 384

  Fly   399 HDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLAENAG 463
            ||||.|:....|....::|||..|:.|:..:...||.::|..:....|||.||..:|:.||:|||
Yeast   385 HDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAG 449

  Fly   464 LNPIATVTELRNRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDI 528
            .:....|::||:....|...:|:::..|.|.|:....:|:...:..:.::.|:|....:|::|:|
Yeast   450 FDSSELVSKLRSSIYNGISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNI 514

  Fly   529 V 529
            :
Yeast   515 I 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	167/521 (32%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	161/502 (32%)
CCT2	NP_012124.1	TCP1_beta	5..520	CDD:239452	167/521 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820