DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and CCT6

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_010474.3	Gene:	CCT6 / 851768	SGDID:	S000002596	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	539	Identity:	142/539 - (26%)
Similarity:	263/539 - (48%)	Gaps:	40/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KDKSKPTDVRLS-NIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAA 81
            |.:|...|..|. |:.:|:.:...:.|:|||:|..||:..|.|.:.:|.||..:|.:|.:..|.|
Yeast     9 KAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTA 73

  Fly    82 KMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQ--M 144
            .::...:.|||...|||||:||.:.|.||....:.:|:|:||..|:|.|:....::::.|.:  :
Yeast    74 VLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKI 138

  Fly   145 STPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLGG 209
            |.....:|||.|::.|.:||.:||.:..:.:|.||..||||.|.| .:..::||..::::.....
Yeast   139 SKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYD-AQADNLDLHMVEIMQMQHL 202

  Fly   210 TVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVIVSDYAAMDRVLKEER 274
            :.:||..:.|||........:.|.|::.|.:.::...:...||:::.....|.....|::...||
Yeast   203 SPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASER 267

  Fly   275 SYI---LNIVKQIKKSGCN-------VLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEF 329
            .::   |..:..:|...|.       |::.||.|...::...|:|     ..:.::..:|.::|.
Yeast   268 KFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKH-----NILALRRAKRRNMER 327

  Fly   330 VCKTLHCRPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMG-RTVSIICRGSNKLVLEE 393
            :..........|::..:.:.|..:.||.:...|..||..:|  :|.. ::.:|:.:||....|.:
Yeast   328 LQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT--ENTDPKSCTILIKGSTHYALAQ 390

  Fly   394 AARSLHDALCVVRCLVKLRAQIVGGGAPEIEMAL--------QLAALAQTVEGVDAYCFRAFADA 450
            ...::.|.|..|..::|.:..|.|.||..|.::.        :|.|..:|..|::     |||:|
Yeast   391 TKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIE-----AFAEA 450

  Fly   451 LEVIPSTLAENAGLNPIATVT----ELRNRHAQGE-KNAGINVRKGAITDIFAENVVQPLLVSIS 510
            |.|||.||.:|:|.:|:..:.    ||.:.....| :..|:::..|...|...|.:.....|..:
Yeast   451 LLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRN 515

  Fly   511 SITLATETIRSILKIDDIV 529
            :||.||....::|..|:::
Yeast   516 AITGATGIASNLLLCDELL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	142/539 (26%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	136/517 (26%)
CCT6	NP_010474.3	chap_CCT_zeta	2..542	CDD:274088	142/539 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810