DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and Hspd1

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_071565.2	Gene:	Hspd1 / 63868	RGDID:	621314	Length:	573	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	121/577 - (20%)
Similarity:	245/577 - (42%)	Gaps:	86/577 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPKAAAVNIKPTAKAFKDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITN 65
            |.|.:.|:....|....||.....|.|...:|....::||:..::||:|...:|:...|...:|.
  Rat    11 MRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTK 75

  Fly    66 DGATILKQMNV----LHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAI 126
            ||.|:.|.:::    .:..||::.:::...:..||||||:..|:|.::.:...:.:.||.:|..|
  Rat    76 DGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEI 140

  Fly   127 SDSFQRCSNKAVEILKQMSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPG 191
            ........:..:..||:.|.|:...  |.:.:.|:.|.|.      ...:..|..||:.||   |
  Rat   141 RRGVMLAVDAVIAELKKQSKPVTTP--EEIAQVATISANG------DKDIGNIISDAMKKV---G 194

  Fly   192 KETSVDLKNIKVISSLGGTVEDTELVDGL---------VFTCRSAG-----SNAPKRIEKAKIGL 242
            ::..:.:|:.|.::      ::.|:::|:         .|...|.|     .:|...:.:.||..
  Rat   195 RKGVITVKDGKTLN------DELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISS 253

  Fly   243 IQFCISAPKTDMDHN---VIVS---DYAAMDRVLKEERSYILNIVKQIKKSGCNVLLV------- 294
            :|..:.|.:....|.   ||::   |..|:.       :.:||.:    |.|..|:.|
  Rat   254 VQSIVPALEIANAHRKPLVIIAEDVDGEALS-------TLVLNRL----KVGLQVVAVKAPGFGD 307

  Fly   295 -QKSILRD-AVSDLAQHFLDKIKCMVVKDVEREDIEFVCKTLHCRPIASL-----DHFTAENLSS 352
             :|:.|:| |::.....|.::...:.::||:..|:..|.:.:..:..|.|     |....|. ..
  Rat   308 NRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEK-RI 371

  Fly   353 ADLVEEVASGTNKFVKITGIQNMGRT---VSII-CRGSNKLVLEEAARSLHDALCVVRCLVKLRA 413
            .::.|::...|:::.|....:.:.:.   |::: ..|::.:.:.|....:.|||...|..|: ..
  Rat   372 QEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVE-EG 435

  Fly   414 QIVGGGAPEIEMALQLAALAQTVE----GVDAYCFRAFADALEVIPSTLAENAGLNPIATVTELR 474
            .::|||...:.....|.:|....|    |::     ....||::...|:|:|||:.....|.::
  Rat   436 IVLGGGCALLRCIPALDSLKPANEDQKIGIE-----IIKRALKIPAMTIAKNAGVEGSLIVEKI- 494

  Fly   475 NRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDIVNT 531
               .|.....|.:...|...::..:.::.|..| :.:..|....:.|:|...:.|.|
  Rat   495 ---LQSSSEVGYDAMLGDFVNMVEKGIIDPTKV-VRTALLDAAGVASLLTTAEAVVT 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	116/558 (21%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	110/537 (20%)
Hspd1	NP_071565.2	GroEL	28..548	CDD:239460	117/560 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810