DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and cct2

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001006757.1	Gene:	cct2 / 448434	XenbaseID:	XB-GENE-1006535	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	537	Identity:	172/537 - (32%)
Similarity:	284/537 - (52%)	Gaps:	35/537 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AAVNIKPTAKAFKDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAG--NGEVSITNDGA 68
            |.|||   .||..|:.|....|||:...|.|:.|.::::|||:||||::.:.  :..|::|||||
Frog     7 APVNI---FKAGADEEKAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDSTVTVTNDGA 68

  Fly    69 TILKQMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRC 133
            ||||.:.:.:|||::||::|:.||...|||||||.|:|..||...|.|:.:.:||..|...:::.
Frog    69 TILKAIGIDNPAAQVLVDMSKVQDDEVGDGTTSVTVLAAELLREAEVLVARKIHPQTIISGWRQA 133

  Fly   134 SNKAVEILKQMSTPIELDD---RETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETS 195
            :..|.|.|...|.....|:   |..|:..|.|:|:||:::......:.:||:|||::...|
Frog   134 TQVAREALLNASVDHGNDEEKFRCDLLNIARTTLSSKLLTHHKDHFSKLAVEAVLRLKGSG---- 194

  Fly   196 VDLKNIKVISSLGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVI- 259
             :|:.|.||..|||::.::.|.:|.:.. :..|.|.|||||.||| ||      ..|.||.:.|
Frog   195 -NLEAIHVIKKLGGSLTESYLDEGFLLD-KKIGVNQPKRIENAKI-LI------ANTGMDTDKIK 250

  Fly   260 -------VSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCM 317
                   |...|.:..:...|:..:...|::|.|.|.|..     |.|..:.:..:........|
Frog   251 IFGSRVRVDSTAKVAEIELAEKEKMKEKVERILKHGINCF-----INRQLIYNYPEQLFATAGVM 310

  Fly   318 VVKDVEREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVSII 382
            .::..:...:|.:.........::.||.....|.:..|:|||..|.:|.:..:|:. ||...:|:
Frog   311 AIEHADFAGVERLALVTGGEIASTFDHPELVKLGTCKLIEEVMIGEDKLIHFSGVA-MGEACTIV 374

  Fly   383 CRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAF 447
            .||:.:.:|:||.|||||||||:...||....:.|||..|:.||..:..||....|.::....:|
Frog   375 LRGATQQILDEAERSLHDALCVLAQTVKDTRTVYGGGCSEMLMAHAVTELAIRTPGKESVAMESF 439

  Fly   448 ADALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSISSI 512
            |.||.::|:.:|:|||.:....|::||..|::|:...|::::.|.|.::....:.:...|....:
Frog   440 AKALRMLPTIIADNAGYDSADLVSQLRAAHSEGKSTYGLDMKNGTIGEMGELGITESFQVKRQVL 504

  Fly   513 TLATETIRSILKIDDIV 529
            ..|:|....||::|:|:
Frog   505 LSASEAAEVILRVDNII 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	166/525 (32%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	158/504 (31%)
cct2	NP_001006757.1	TCP1_beta	11..527	CDD:239452	169/533 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920