DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and CCT1

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	170/546 - (31%)
Similarity:	288/546 - (52%)	Gaps:	29/546 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPKAAAVNIKPTAKAFKDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITN 65
            |:..|:.::|..|      :.....||..|:.||.::|:.:::||||.|:|||:....|:|::||
  Fly     1 MSTLASPLSIAGT------RQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTN 59

  Fly    66 DGATILKQMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSF 130
            ||||||:.:.|.|||||:||||::.||...||||||||::|..||:..::|:::.:|||:|...:
  Fly    60 DGATILRLLEVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGY 124

  Fly   131 Q-RCSNKAVEILKQMSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAV--LKVTDPGK 192
            : .|......|.:.::.|::...|::||..|.||::||::...:...:.:.|||.  :|:|||..
  Fly   125 RIACKEACKYISEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRG 189

  Fly   193 ETSVDLKNIKVISSLGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHN 257
            :.:..:|.|.|:.:.|.:..::.|:.|....|..|....||:|..|||..:.|.:...|..|...
  Fly   190 QAAYSIKAINVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQ 254

  Fly   258 VIVSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDV 322
            |:::|...::.:...|.......:..|..:|.||:||.     ..|.||...:..:...|.|:.|
  Fly   255 VLINDPDKLEAIRARELDITKERINMILGTGVNVVLVS-----GGVDDLCMKYFVEAGAMAVRRV 314

  Fly   323 EREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVASGT------NKFVKITGIQNMGRTVSI 381
            ::.|::.:.|......|.||.:...|....|.:|.|.|...      ::.:.|.|.:... ..||
  Fly   315 KKSDLKIIAKATGAAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARA-AASI 378

  Fly   382 ICRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRA 446
            |.||.|....:|..||:|||||||:.:::.:..:.|||..|..:::.|...|.::...:......
  Fly   379 ILRGPNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAE 443

  Fly   447 FADALEVIPSTLAENAGLNPIATVTELRNRHAQGE--------KNAGINVRKGAITDIFAENVVQ 503
            ||.:|.|||.||:.||..:....|.:||:.|...:        |..|:::.:|.:.|.....|::
  Fly   444 FAKSLLVIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLE 508

  Fly   504 PLLVSISSITLATETIRSILKIDDIV 529
            |.:..|.|:..|||...:||:|||::
  Fly   509 PAMSKIKSLKFATEAAITILRIDDMI 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	166/529 (31%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	161/508 (32%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	167/535 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840