DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and cct8

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_005155423.1	Gene:	cct8 / 394037	ZFINID:	ZDB-GENE-040426-876	Length:	558	Species:	Danio rerio

Alignment Length:	538	Identity:	158/538 - (29%)
Similarity:	269/538 - (50%)	Gaps:	29/538 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PKAAAVNIKPTAKAFKDKSKP----TDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSI 63
            |||...     |:..||.:|.    .:....||||.|.::...||:.||.||:||:.....::.:
Zfish     6 PKAPGF-----AQMLKDGAKHYSGLEEAVFRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFV 65

  Fly    64 TNDGATILKQMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISD 128
            |||.||||:::.|.||||||:|..|..|:...||||..|:|.||||||..|:||:.||..:.:.:
Zfish    66 TNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRMGLSVSEVIE 130

  Fly   129 SFQRCSNKAVEILKQ--MSTPIELDDRETLIKSASTSLNSKVVSQQ---SSLLAPIAVDAVLKVT 188
            .::....||:|||..  .|:...|.|    ::.|:..:.|.|:|:|   ...||.:...|.:.:.
Zfish   131 GYEMACKKALEILPDCVCSSAKNLHD----LEEATAMIRSAVMSKQYGNEDFLANLIAQACVSIF 191

  Fly   189 DPGKETSVDLKNIKVISSLGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTD 253
            ......:||  |::|...||..:..:.::.|:||...:.|.  ...::.|||.:.........|:
Zfish   192 PESGSFNVD--NVRVCKILGCGLNSSTMLHGMVFKKEAEGD--VTSVKDAKIAVFSCPFDCTVTE 252

  Fly   254 MDHNVIVSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMV 318
            ....|::.:...:....|.|...:...||.|..||.:|:     :....|:|:|.|:.:|.|.||
Zfish   253 TKGTVLIKNADELMNFSKGEEDLMEAQVKAIADSGASVV-----VTGGKVADMALHYANKYKLMV 312

  Fly   319 VKDVEREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVSIIC 383
            |:...:.|:..:|||:....:..|...|.|.:...|.|.....|..:.|.....:..|...:::.
Zfish   313 VRLNSKWDLRRLCKTVGATALPRLTSPTPEEMGRCDSVYLSEVGDTQVVVFKHDKEDGAISTLVI 377

  Fly   384 RGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFA 448
            |||...::::..|::.|.:...:.||:......|.||.|||:|..:.:..::..|::.|..:.:|
Zfish   378 RGSTDNLMDDIERAIDDGVNTFKVLVRDARLCPGAGATEIELAKHITSYGESCPGLEQYAIKKYA 442

  Fly   449 DALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVR-KG-AITDIFAENVVQPLLVSISS 511
            :|.|.:|..||||:|:.....:::|...|.:|.||:|.::. :| |:.|:....::.|.||....
Zfish   443 EAFEALPRALAENSGVKGNELISKLYATHHEGNKNSGFDIEGEGPAVRDMMEAGILDPYLVKYWG 507

  Fly   512 ITLATETIRSILKIDDIV 529
            |.|||....::|::|.|:
Zfish   508 IKLATNAAITVLRVDQII 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	154/523 (29%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	145/498 (29%)
cct8	XP_005155423.1	chap_CCT_theta	10..539	CDD:274087	155/534 (29%)
cct8	XP_005155423.1	Cpn60_TCP1	39..528	CDD:278544	146/500 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920