DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and Hsp60D

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	126/574 - (21%)
Similarity:	227/574 - (39%)	Gaps:	130/574 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAAKMLVELSR 89
            :.|...:|....:::|:.|:|||:|.:.:|:.......||.||.|:...:.:.:....|.|:|.|
  Fly    25 EARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQLGNRRQDMGVQLLR 89

  Fly    90 A----QDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQMSTPIEL 150
            .    .:...|||||:..::|..:  ||:     |:|                 :|:|....::|
  Fly    90 QATNNTNNKVGDGTTTATILARGI--ACQ-----GMH-----------------VLRQSKVNVQL 130

  Fly   151 DDRETLIKSASTSLNSKVVSQQSSLLAPIA-VDAVLKVTDPGKETSVDLKNIKVISSLGGTVEDT 214
             .||.:::.:....::  :.:.|..:..|. |:||.||...|.|...:|        :|..:  .
  Fly   131 -LREGILEGSRAVCDA--LGEMSQSVDTIGQVEAVAKVALNGDERLAEL--------IGDII--L 182

  Fly   215 ELVDGLVFTCRSAGSNAPKRIEKAKI--GLI--------QFCISAPKTDMDHNVIVSDYAAMDRV 269
            ||.|..|...:.  |::|  .::|||  |:.        .|...:...::::.:::...|.:|:|
  Fly   183 ELGDSGVILLKE--SHSP--FDEAKIQEGITIASGYYSPFFAKQSHTLELENCLLLLTLAKIDQV 243

  Fly   270 LKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLD-KIKCMVVKD--------VERE 325
                 ..||..::..:.....:|::.|:...|.:..|..:.|. :::...||.        .|.|
  Fly   244 -----EQILPALELARLKERPLLIIAKNFGSDLLKILVLNNLQGRVQVCAVKAPSFGDEQCEEME 303

  Fly   326 DIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVASGTNKFV---------------------KI 369
            ||.|          |:..|...:..|.|||.||......:.|                     :|
  Fly   304 DIAF----------ATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQVQCRI 358

  Fly   370 TGIQNM---------------------GRTVSIICRGSNKLVLEEAARSLHDALCVVRCLVKLRA 413
            ..|:.:                     |...:|...|:::|.:.|.....:|||..||..:. ..
  Fly   359 QDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAIS-DG 422

  Fly   414 QIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFA-DALEVIPSTLAENAGLNPIATVTELRNRH 477
            .:.|||...:.....|..|..| :.::....|... |||.:...|:|.|||::|    .|:..|.
  Fly   423 VVPGGGTAYLRCIPVLDELPPT-DIMELQVGREIVKDALRLPCYTIARNAGVDP----NEVLRRV 482

  Fly   478 AQGEKNAGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDIVNT 531
            .:|..|.|.:...|...|:....:|.|..|..|::|.|. .|.|:|...:::.|
  Fly   483 LKGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAA-GIASLLATTEVLIT 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	125/572 (22%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	123/558 (22%)
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	126/574 (22%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	126/574 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740