DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and Mkks

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001008354.1	Gene:	Mkks / 311456	RGDID:	1308814	Length:	570	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	101/488 - (20%)
Similarity:	193/488 - (39%)	Gaps:	74/488 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LSNIQAAK--------AVSDAIRTSL-----------GPRGMDKMIQAG-NGEVSITNDGATILK 72
            :|.::|.|        ..|:.:|::|           ||.|..|.:..| .|.|..|:..:.:|:
  Rat     1 MSRLEAKKPSLCKTEPLTSERVRSTLSVLKGIIASCYGPSGRLKQLHNGLGGCVCTTSQSSALLR 65

  Fly    73 QMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKA 137
            .::|.||..|:|....:.......|......::...|:|..:::   ||.||......:.....:
  Rat    66 NLSVTHPILKVLTSSVQNHVCCFSDCGLFTAILCCNLIENIQRI---GLTPTTAIKLNKYLLGLS 127

  Fly   138 VEILKQ--MSTPIELDDRETLIKSASTSLN---SKVVSQQSSLLAPIAVDAV---------LKVT 188
            :..||.  .|..|.:|.|.|     .|.||   |.:.|:.:.:|....:|.:         |.:.
  Rat   128 ISYLKSEACSCRIPVDFRST-----HTFLNLVHSILTSKPACMLTRKEIDHIGALILKAFLLTIP 187

  Fly   189 DPGKETSVDLKNIKVISSLGGTVEDTELVDGLVFTCRSAGSNAPKRI----EKAKIGLIQFC--I 247
            :..:|..|..|:| ::...|..|.|:.::.||:.   .|.....:|:    :.:.:.:..||  :
  Rat   188 ESAEERMVLGKSI-IVPLKGQQVTDSTVLPGLLI---EASEVQLRRLLPTQKSSTLRVALFCASL 248

  Fly   248 SAPKTDMDHNVIVSDY-AAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFL 311
            |...::.....:|..| .:::..:.|:   :||:.:|:.....:::|.||     .:....:.||
  Rat   249 SGDFSNAGEGTLVVHYQVSLENAVLEQ---LLNLGRQLVSDHVDLVLCQK-----VIHPSLKQFL 305

  Fly   312 DKIKCMVVKDVEREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMG 376
            .:.:.:.:..|....:|.:.|.....||.||....:....|...|.....|:..|..:  :.|..
  Rat   306 SEHQIIAIDRVGVTLMEPLSKVTGATPIGSLYPIVSTTYGSVKDVRSARFGSKYFFHL--LPNEA 368

  Fly   377 RTVSIICRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLA-ALAQTVEGV- 439
            ...|::....|....||...:...|:.|::..:|....::|||..|..:|..:. .:....|.:
  Rat   369 TICSLLLCSRNDTAWEELKLTCQTAMHVLQLTIKEPWVLLGGGCVETHLAAYIRHKVHNEAEAIV 433

  Fly   440 -DAYCFR--------AFADALEVIPSTLAENAG 463
             |..|.:        ||..|||....:|..:.|
  Rat   434 RDDGCSQAELHIATEAFCSALESAAVSLEHDGG 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	101/488 (21%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	98/471 (21%)
Mkks	NP_001008354.1	Cpn60_TCP1	29..569	CDD:278544	95/460 (21%)
Mkks	NP_001008354.1	chaperonin_like	32..456	CDD:295468	92/445 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810