DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and Cct2

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_038934664.1	Gene:	Cct2 / 299809	RGDID:	1359143	Length:	561	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	178/539 - (33%)
Similarity:	283/539 - (52%)	Gaps:	39/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AAVNIKPTAKAFKDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVS--ITNDGA 68
            |.|||   .||..|:.:....|||:...|.|:.|.::::|||:||||::.:...:.|  :|||||
  Rat    33 APVNI---FKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGA 94

  Fly    69 TILKQMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRC 133
            ||||.:.|.:||||:||::||.||...|||||||.|:|..||...|.|:.|.:||..|...::..
  Rat    95 TILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREA 159

  Fly   134 SNKAVEILKQMSTPIELDDRET-----LIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKE 193
            :..|.|.|  :|:.::....|.     |:..|.|:|:||:::........:||:|||::...|
  Rat   160 TKAAREAL--LSSAVDHGSDEVKFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSG-- 220

  Fly   194 TSVDLKNIKVISSLGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNV 258
               :|:.|.||..|||::.|:.|.:|.:.. :..|.|.|||||.||| ||      ..|.||.:.
  Rat   221 ---NLEAIHVIKKLGGSLADSYLDEGFLLD-KKIGVNQPKRIENAKI-LI------ANTGMDTDK 274

  Fly   259 I--------VSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIK 315
            |        |...|.:..:...|:..:...|::|.|.|.|..     |.|..:.:..:.......
  Rat   275 IKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCF-----INRQLIYNYPEQLFGAAG 334

  Fly   316 CMVVKDVEREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVS 380
            .|.::..:...:|.:.........::.||.....|.|..|:|||..|.:|.:..:|:. :|...:
  Rat   335 VMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVA-LGEACT 398

  Fly   381 IICRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFR 445
            |:.||:.:.:|:||.|||||||||:...||....:.|||..|:.||..:..||....|.:|....
  Rat   399 IVLRGATQQILDEAERSLHDALCVLAQTVKDPRTVYGGGCSEMLMAHAVTMLASRTPGKEAVAME 463

  Fly   446 AFADALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSIS 510
            :||.||.::|:.:|:|||.:....|.:||..|::|...||:::::|:|.|:....:.:...|...
  Rat   464 SFAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGRITAGLDMKEGSIGDMAVLGITESFQVKRQ 528

  Fly   511 SITLATETIRSILKIDDIV 529
            .:..|.|....||::|:|:
  Rat   529 VLLSAAEAAEVILRVDNII 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	172/527 (33%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	165/506 (33%)
Cct2	XP_038934664.1	TCP1_beta	37..553	CDD:239452	175/535 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820