DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and CCT5

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_036205.1	Gene:	CCT5 / 22948	HGNCID:	1618	Length:	541	Species:	Homo sapiens

Alignment Length:	510	Identity:	213/510 - (41%)
Similarity:	312/510 - (61%)	Gaps:	22/510 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAAKMLVELSRAQDV 93
            |:|.|||||::.:||||||.|:|||:...:|:|::||||||||..|:|.|..||::||||::||.
Human    36 SHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDD 100

  Fly    94 AAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQMSTPIELD--DRETL 156
            ..|||||.|||:||||||..|:||.:|:||..|:|.:::.:..|:|.|.::|..:.:|  |.|.|
Human   101 EIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPL 165

  Fly   157 IKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLGGTVEDTELVDGLV 221
            |::|.|:|.||||:.....:|.|||:|||.|.|. :...||.:.|||...:||.:|||:|:.|::
Human   166 IQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADM-ERRDVDFELIKVEGKVGGRLEDTKLIKGVI 229

  Fly   222 FTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNV---IVSDYAAMDRVLKEERSYILNIVKQ 283
            .....:....||::|.|||.::......||....|.:   .|.||.|:.:..||:   ...:::|
Human   230 VDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEK---FEEMIQQ 291

  Fly   284 IKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCKTLHCRPIASLDHFTAE 348
            ||::|.|:.:.|...     .|.|.|.|.:.....|:.|...:||.:......|.:......|||
Human   292 IKETGANLAICQWGF-----DDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAE 351

  Fly   349 NLSSADLVEEVASGT--NKFVKITGIQNMGRTVSIICRGSNKLVLEEAARSLHDALCVVRCLVKL 411
            .|..|.||:|::.||  :|.:.|...:| .|.|:|..||.||:::|||.|||||||||:|.|::.
Human   352 KLGFAGLVQEISFGTTKDKMLVIEQCKN-SRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRD 415

  Fly   412 RAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLAENAGLNPIATVTELRNR 476
            ...:.||||.||..||.::..|.....::.|..|||||||||||..|:||:|:|||.|:||:|.|
Human   416 NRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480

  Fly   477 HAQGEKNAGINV---RKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDI 528
            ..: |.|..:.:   .||. .|:..::|::.|:.....|:|||:.:|.|||||||
Human   481 QVK-EMNPALGIDCLHKGT-NDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	213/510 (42%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	207/502 (41%)
CCT5	NP_036205.1	TCP1_epsilon	10..535	CDD:239455	213/510 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830