DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT4 and cct7

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_775355.1	Gene:	cct7 / 192324	ZFINID:	ZDB-GENE-020419-7	Length:	547	Species:	Danio rerio

Alignment Length:	521	Identity:	180/521 - (34%)
Similarity:	288/521 - (55%)	Gaps:	24/521 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAAKM 83
            |.|:.....:|||.|.:.|::|:||:||||||||::....|:.:|:||||||||.::|:|||||.
Zfish    14 DTSQGVPQLVSNINACQVVAEAVRTTLGPRGMDKLVVDNRGKATISNDGATILKLLDVVHPAAKT 78

  Fly    84 LVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQMSTPI 148
            ||:::|:||...|||||||.::|...|:..:..:::||||..|..:|:..:..||:.:|:::..|
Zfish    79 LVDIARSQDAEVGDGTTSVTLLAAEFLKQLKPYVEEGLHPQTIIRAFRIATQLAVKKIKEIAVTI 143

  Fly   149 ELDD----RETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLGG 209
            :.||    |..|.|.|:|:||||:::.|....:.:.||||:.:.|     .:.||.|.|....||
Zfish   144 KKDDKQEQRRLLEKCAATALNSKLIAGQKDFFSKMVVDAVMMLDD-----LLPLKMIGVKKVQGG 203

  Fly   210 TVEDTELVDGLVF--TCRSAG-SNAPKRIEKAKIGL--IQFCISAPKTDMDHNV-IVSDYAAMDR 268
            .:|:::||.|:.|  |...|| ...|||....||.|  |:..:.|.|.:.:..| .:.||.|
Zfish   204 ALEESQLVAGVAFKKTFSYAGFEMQPKRYMNPKIALLNIELELKAEKDNAEVRVNSMEDYQA--- 265

  Fly   269 VLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCKT 333
            ::..|.:.:.:.:::|.|||..|:|.:..|     .|:|..:...........|..|:::.....
Zfish   266 IVDAEWNILYDKLEKIHKSGAKVVLSKLPI-----GDVATQYFAYRNLFCAARVVEENLKRTMMA 325

  Fly   334 LHCRPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVSIICRGSNKLVLEEAARSL 398
            .......|:...|.:.|...:|.|||..|..::....|... .:|.:||.||..:..:||..|||
Zfish   326 CGGSIQTSVGSLTDDVLGQCELFEEVQVGGERYNFFKGCPK-AKTCTIILRGGAEQFMEETDRSL 389

  Fly   399 HDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLAENAG 463
            |||:.:||..:|..:.:.||||.|:|::..|...::|:.|.......|:|.|||:||..|.:|||
Zfish   390 HDAIMIVRRAIKNDSIVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAG 454

  Fly   464 LNPIATVTELRNRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDI 528
            .:....:.:||.:||||....|::|....|.|.|...|.:|.:|.|:::|.|:|....||.:|:.
Zfish   455 FDATNILNKLRAKHAQGGMWYGVDVNNEDIADNFQACVWEPSIVRINALTAASEAACLILSVDET 519

  Fly   529 V 529
            :
Zfish   520 I 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	180/521 (35%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	174/501 (35%)
cct7	NP_775355.1	chap_CCT_eta	4..525	CDD:274086	180/521 (35%)
cct7	NP_775355.1	TCP1_eta	5..525	CDD:239456	180/521 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820