DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and cct-3

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_494218.2	Gene:	cct-3 / 173581	WormBaseID:	WBGene00018782	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	161/519 - (31%)
Similarity:	267/519 - (51%)	Gaps:	29/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAAKMLVELSRA 90
            |::.||.|.|.::|.||||||||.|.||:....|.:.:||||..||:::.|.|||||.::|::|.
Worm    24 VQIGNINACKTIADVIRTSLGPRAMLKMLMDPMGGIVMTNDGNAILREITVKHPAAKSMIEIART 88

  Fly    91 QDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPT--------AISDSFQRCSNKAVEILKQMSTP 147
            ||...|||||||:::||.::...:..|::..|||        |:.|..|...||       .|..
Worm    89 QDEETGDGTTSVIILAGEVMAHAQTYLEQKTHPTLIIKAYRQALEDMIQWSENK-------FSKT 146

  Fly   148 IELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAV--LKVTDPGKETSVDLKNIKVISSL-GG 209
            :::.|...:.|...:.|.:|::|:...|...|::.||  ::|...|.. .:|:|....|..: ||
Worm   147 VDITDDAEIAKVVKSCLGTKMISKWMDLAVNISIQAVKTIRVEKAGVR-EIDIKRYCRIEKIPGG 210

  Fly   210 TVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVIVSDYAAMDRVLKEER 274
            .:||:::|.|:|.......:...:|||..:|.|:...:...|.:...::.:.....:..:|::|.
Worm   211 RIEDSQVVKGIVVNKDILHAKMRRRIENPRIVLLDCNLEYKKGESQTSLEIMREEDISAILEQEE 275

  Fly   275 SYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCKTLHCRPI 339
            ..|.....:|.|...:::..:|.|     ||||||||.|.....::.:::.|...:.:....|.:
Worm   276 QAIRKQCDEIIKLKPDLVFTEKGI-----SDLAQHFLLKAGITCLRRLKKTDNNRLARVCGARVV 335

  Fly   340 ASLDHFTAENL-SSADLVEEVASGTNKFVKITGIQNMGRTVSIICRGSNKLVLEEAARSLHDALC 403
            ........|:: :.|.|.|.|......:..:|.......||  :.||.:|.|:.|..|:|.|:|.
Worm   336 HDTSDLRDEDVGTKAQLFEVVKIADEYYTYVTAETTTACTV--VLRGPSKDVINEVERNLQDSLH 398

  Fly   404 VVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLAENAGLNPIA 468
            |||.::.....:.||||.|:.::.::......::||..:.::|...||||||.||.:|.|.:.|.
Worm   399 VVRNIMINPKLVPGGGALEMALSREIEQQGAKMDGVKKWPYKAIGLALEVIPRTLIQNCGGSTIR 463

  Fly   469 TVTELRNRHAQGEKN--AGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDIVN 530
            .:||||..|||..:|  .|::...|.:.|:....:..||.|.|..:..|.||...:|:|||||:
Worm   464 KMTELRAIHAQNAENWTFGVDGTSGDLVDMNKLEIWDPLAVRIQVLKTAIETSVMLLRIDDIVS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	161/519 (31%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	154/505 (30%)
cct-3	NP_494218.2	chap_CCT_gamma	8..531	CDD:274085	161/519 (31%)
cct-3	NP_494218.2	TCP1_gamma	8..528	CDD:239453	161/519 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820