DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and Cct4

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_033967.1	Gene:	Cct4 / 12464	MGIID:	104689	Length:	539	Species:	Mus musculus

Alignment Length:	539	Identity:	369/539 - (68%)
Similarity:	454/539 - (84%)	Gaps:	9/539 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPKAAAVNIKPTA-------KAFKDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGN 58
            |....|:.:..|||       .|::|:.||..:|.|||.|||||:|||||||||:|||||||.|.
Mouse     1 MPENVASRSGAPTAGPGSRGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGK 65

  Fly    59 GEVSITNDGATILKQMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHP 123
            |:|:||||||||||||.||||||:||||||:|||:.|||||||||:|||:||::|.||||||:||
Mouse    66 GDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHP 130

  Fly   124 TAISDSFQRCSNKAVEILKQMSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVT 188
            |.||:|||:...|.:|||..||.|::|.|||||:.||:||||||||||.||||:|::|:||:||.
Mouse   131 TIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVI 195

  Fly   189 DPGKETSVDLKNIKVISSLGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTD 253
            ||...|||||::||::..||||::|.|||:|||.|.:.|.|.. .|:|||||||||||:||||||
Mouse   196 DPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGI-TRVEKAKIGLIQFCLSAPKTD 259

  Fly   254 MDHNVIVSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMV 318
            ||:.::|||||.|||||:|||:||||:||||||:||||||:||||||||:||||.|||:|:|.||
Mouse   260 MDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMV 324

  Fly   319 VKDVEREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVA-SGTNKFVKITGIQNMGRTVSII 382
            |||||||||||:|||:..:|:|.:|.|||:.|.||:|.|||: :|:.|..||||..:.|:||:|:
Mouse   325 VKDVEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIV 389

  Fly   383 CRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAF 447
            .|||||||:|||.||:||||||:|||||.||.|.||||||||:||:|...::|:.|:::||.|||
Mouse   390 VRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAF 454

  Fly   448 ADALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSISSI 512
            |||:||||||||||||||||:||||||||||||||..|||||||.|::|..|.||||||||:|::
Mouse   455 ADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSAL 519

  Fly   513 TLATETIRSILKIDDIVNT 531
            ||||||:||||||||:|||
Mouse   520 TLATETVRSILKIDDVVNT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	361/513 (70%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	349/492 (71%)
Cct4	NP_033967.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		7/27 (26%)
		TCP1_delta	25..538	CDD:239454	361/513 (70%)
		Cpn60_TCP1	44..539	CDD:278544	352/496 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848333
Domainoid	1	1.000	700	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4695
Inparanoid	1	1.050	727	1.000	Inparanoid score	I616
Isobase	1	0.950	-	0	Normalized mean entropy	S124
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0004921
OrthoInspector	1	1.000	-	-		oto92072
orthoMCL	1	0.900	-	-		OOG6_101757
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1486
SonicParanoid	1	1.000	-	-		X3470
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750