DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT4 and Cct3

DIOPT Version :9

Sequence 1:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_033966.1	Gene:	Cct3 / 12462	MGIID:	104708	Length:	545	Species:	Mus musculus

Alignment Length:	511	Identity:	166/511 - (32%)
Similarity:	291/511 - (56%)	Gaps:	14/511 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAAKMLVELSRA 90
            |:..||.|||.::|.|||.|||:.|.||:....|.:.:||||..||:::.|.|||||.::|:||.
Mouse    22 VQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRT 86

  Fly    91 QDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQMSTPIELDDRET 155
            ||...|||||||:::||.:|...|..|::.:|||.:..:::...:..:..||::|||:::::||.
Mouse    87 QDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKISTPVDVNNREM 151

  Fly   156 LIKSASTSLNSKVVSQQSSLLAPIAVDAV--LKVTDPGKETSVDLKNIKVISSL-GGTVEDTELV 217
            ::...::|:.:||:|:.|||...||:|||  ::..:.|:: .:|:|....:..: ||.:||:.::
Mouse   152 MLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRK-EIDIKKYARVEKIPGGIIEDSCVL 215

  Fly   218 DGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVIVSDYAAMDRVLKEERSYILNIVK 282
            .|::...........:.|:..:|.|:...:...|.:...::.::......|:|:.|..||..:.:
Mouse   216 RGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIHQLCE 280

  Fly   283 QIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCKTLHCRPIASLDHFTA 347
            .|.:...:|::.:|.|     ||||||:|.:.....::.|.:.|...:.:....|.::..:....
Mouse   281 DIIQLKPDVVITEKGI-----SDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELRE 340

  Fly   348 ENL-SSADLVEEVASGTNKFVKITGIQNMGRTVSIICRGSNKLVLEEAARSLHDALCVVRCLVKL 411
            ::: :.|.|:|....|...|..||..:: .:..:|:.||::|.:|.|..|:|.||:.|.| .|.|
Mouse   341 DDVGTGAGLLEIKKIGDEYFTFITDCKD-PKACTILLRGASKEILSEVERNLQDAMQVCR-NVLL 403

  Fly   412 RAQIV-GGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLAENAGLNPIATVTELRN 475
            ..|:| ||||.|:.:|..|...::.:.||:.:.:||.|.||||||.||.:|.|.:.|..:|.||.
Mouse   404 DPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRA 468

  Fly   476 RHAQGE-KNAGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDIVN 530
            :|.|.. :..|:|...|.:.|:....:.:||.|.:.:...|.||...:|:|||||:
Mouse   469 KHTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	166/511 (32%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	158/497 (32%)
Cct3	NP_033966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		1/1 (100%)
		chap_CCT_gamma	6..529	CDD:274085	166/511 (32%)
		TCP1_gamma	6..525	CDD:239453	166/511 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810