Protein Alignment pdm2 and POU4F2

DIOPT Version :10

• Sequence 1: NP_723763.1
• Gene: pdm2 / 34673
• FlyBaseID: FBgn0004394
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_004566.2
• Gene: POU4F2 / 5458
• HGNCID: 9219
• Length: 409
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 102/328 - (31%)
• Similarity: 150/328 - (45%)
• Gaps: 75/328 - (22%)

  Fly   571 LQNSL----QALAQFQALQQMKQQQREDP----------------LPSYSTPLAKS-PLRSPSLS 614
            |..||    :|||....:.|.|......|                :|..|...:.| |:..||..
Human   103 LDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSAL 167

  Fly   615 PVPRH-----------------SKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPK 662
            ....|                 .:..:...|........|...||:  :||:  ..|.:....|.
Human   168 AGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVV--STPA--HAPHMATMNPM 228

  Fly   663 PTSGLTVASA---------MAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG--K 716
            ..:.|::|.|         |:.::..|      .:||.||:.|||||||||.||.|||.|:.  |
Human   229 HQAALSMAHAHGLPSHMGCMSDVDADP------RDLEAFAERFKQRRIKLGVTQADVGSALANLK 287

  Fly   717 LYG-NDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPE 780
            :.| ...||:||.|||:|.||..||..|||:||.|||:|:.:..:.              .:.||
Human   288 IPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREK--------------LTKPE 338

  Fly   781 SILG-RRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRI 844
            ...| .:::|||||....:.:||..|.:..:|:||:|:.::|:|::.|.|:||||||:|||:||:
Human   339 LFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403

  Fly   845 NPS 847
            ..|
Human   404 KYS 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pdm2	NP_723763.1	PHA03247	<375..675	CDD:223021	28/150 (19%)
		POU	691..755	CDD:197673	39/66 (59%)
		Homeodomain	787..843	CDD:459649	25/55 (45%)
POU4F2	NP_004566.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..93
		Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q63934	91..237		25/137 (18%)
		POU-IV box	110..119		3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..188		5/34 (15%)
		Nuclear speckle targeting signal. /evidence=ECO:0000269|PubMed:19266028	171..185		1/13 (8%)
		Required for DNA-binding and transcriptional repression. /evidence=ECO:0000250|UniProtKB:Q63934	238..409		76/189 (40%)
		POU	250..327	CDD:197673	42/82 (51%)
		Homeodomain	346..402	CDD:459649	25/55 (45%)