DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdm2 and POU4F2

DIOPT Version :9

Sequence 1:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_004566.2	Gene:	POU4F2 / 5458	HGNCID:	9219	Length:	409	Species:	Homo sapiens

Alignment Length:	328	Identity:	102/328 - (31%)
Similarity:	150/328 - (45%)	Gaps:	75/328 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 LQNSL----QALAQFQALQQMKQQQREDP----------------LPSYSTPLAKS-PLRSPSLS 614
            |..||    :|||....:.|.|......|                :|..|...:.| |:..||..
Human   103 LDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSAL 167

  Fly   615 PVPRH-----------------SKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPK 662
            ....|                 .:..:...|........|...||:  :||:  ..|.:....|.
Human   168 AGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVV--STPA--HAPHMATMNPM 228

  Fly   663 PTSGLTVASA---------MAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG--K 716
            ..:.|::|.|         |:.::..|      .:||.||:.|||||||||.||.|||.|:.  |
Human   229 HQAALSMAHAHGLPSHMGCMSDVDADP------RDLEAFAERFKQRRIKLGVTQADVGSALANLK 287

  Fly   717 LYG-NDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPE 780
            :.| ...||:||.|||:|.||..||..|||:||.|||:|:.:..:.              .:.||
Human   288 IPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREK--------------LTKPE 338

  Fly   781 SILG-RRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRI 844
            ...| .:::|||||....:.:||..|.:..:|:||:|:.::|:|::.|.|:||||||:|||:||:
Human   339 LFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403

  Fly   845 NPS 847
            ..|
Human   404 KYS 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm2	NP_001285877.1	POU	691..755	CDD:197673	39/66 (59%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	25/52 (48%)
POU4F2	NP_004566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..93
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q63934	91..237		25/137 (18%)
		POU-IV box	110..119		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..188		5/34 (15%)
		Nuclear speckle targeting signal. /evidence=ECO:0000269\|PubMed:19266028	171..185		1/13 (8%)
		Required for DNA-binding and transcriptional repression. /evidence=ECO:0000250\|UniProtKB:Q63934	238..409		76/189 (40%)
		POU	250..327	CDD:197673	42/82 (51%)
		Homeobox	348..401	CDD:278475	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810