DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdm2 and Pou6f1

DIOPT Version :9

Sequence 1:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_006520671.1	Gene:	Pou6f1 / 19009	MGIID:	102935	Length:	610	Species:	Mus musculus

Alignment Length:	547	Identity:	144/547 - (26%)
Similarity:	212/547 - (38%)	Gaps:	144/547 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 TLRKPHVVPSELEHNHHWHGVVCDANGHATRLLHIAPPRAGPTPLP--THQQPPVGEVLPP---- 410
            |:.:|.::|..:.      |.|....|.|...:    |.|....||  |...|..|...||
Mouse   141 TVTQPLLIPIGIT------GQVAGQQGLAVWTI----PTATVAALPGLTAASPTGGTFKPPLAGL 195

  Fly   411 -----NSTSFSTIVD--PPKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPPSPLRSLSDCGKSF 468
                 .:|:..|.|.  ||.:.|...||.|                  |..|.||         |
Mouse   196 QAAAVLNTALPTPVQAAPPIQASSPAQPRP------------------PAQPQPL---------F 233

  Fly   469 EEEELELGENCEMPQNLSSKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNP-----PQ 528
            :.:.|.......:||..::               ...||.|          |.....|     |.
Mouse   234 QTQPLLQTTPAILPQPTAA---------------TVAAPTP----------KTVDATPQITVQPA 273

  Fly   529 PVAFAPEEMHQALQLQLHSYIEMVRQL--AP---EAFPN-PNLATQFLLQNSLQALAQFQALQQM 587
            ..||:|..:..|   .|....:::..|  ||   ...|: |.:::|.|..      ||.|.:..:
Mouse   274 GFAFSPGIISAA---SLGGQTQILGSLTTAPVITNTIPSMPGISSQILTN------AQGQVIGAL 329

  Fly   588 ----KQQQREDPLPSYS------TP-------------LAKSPL------RSPSLSPVPRHSKSQ 623
                .......|.|:.|      ||             ||.|||      |.|:....|..|:.|
Mouse   330 PWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPESPAKSEVQ 394

  Fly   624 QRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSP---EETTD 685
            ...|     ..::...:.::|..||::  :|......|...|.....|.:.....:|   |:..:
Mouse   395 PIQP-----TQAVPQPAVILTSPTPAL--KPSAATPIPITCSETPTVSQLVSKPHTPSLDEDGIN 452

  Fly   686 LEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKW 750
            |||:.:|||.||.||:.||.||..||.|:....|..:||:.|.|||.|:::.|:..||||:|:||
Mouse   453 LEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKW 517

  Fly   751 LEDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEE 815
            |.:|:   .::..|..|:........|       ::||:|||........|...|..|..||.:|
Mouse   518 LMEAE---LRNQEGQQNLMEFVGGEPS-------KKRKRRTSFTPQAIEALNAYFEKNPLPTGQE 572

  Fly   816 ISQLSERLNMDKEVIRVWFCNRRQKEK 842
            |:::::.||.|:||:|||||||||..|
Mouse   573 ITEIAKELNYDREVVRVWFCNRRQTLK 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm2	NP_001285877.1	POU	691..755	CDD:197673	31/63 (49%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	24/52 (46%)
Pou6f1	XP_006520671.1	PHA03247	<48..425	CDD:223021	74/361 (20%)
		Pou	448..522	CDD:389985	35/73 (48%)
		Homeobox	546..600	CDD:365835	25/54 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810