DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdm2 and Pou2f3

DIOPT Version :9

Sequence 1:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_035269.2	Gene:	Pou2f3 / 18988	MGIID:	102565	Length:	431	Species:	Mus musculus

Alignment Length:	442	Identity:	177/442 - (40%)
Similarity:	213/442 - (48%)	Gaps:	124/442 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 LSSKRQAR------ELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQL 543
            |...||.:      .|...|.:....|:..|..:...|....:||::|.|.:...|..:..
Mouse    39 LDFNRQIKTEDLGDSLQQTLSHRPCHLSQGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQS---- 99

  Fly   544 QLHSYIEMVRQLAPEAFPNPNLATQFLL------QNSLQALAQFQALQQMKQQQREDPLPSYSTP 602
                                  .:||||      |..||     ..|....|||....||.....
Mouse   100 ----------------------VSQFLLSQTPPGQQGLQ-----PNLLSFPQQQSTLLLPQTGPG 137

  Fly   603 LAKSPLRSPSLSPVPRHSKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGL 667
            ||...:..|                         |:|.:.:.|:..:.|..|     .||...|
Mouse   138 LASQAVGRP-------------------------GLSGSSLEPHLDAPQHLP-----GPKHLPG- 171

  Fly   668 TVASAMAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEA 732
                     ....:|.|||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse   172 ---------PGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEA 227

  Fly   733 LNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTP--ESILGRRRKKRTSIET 795
            |||||||||||||||:|||.||:|:.:         :...||.||.|  ..:.||:|||||||||
Mouse   228 LNLSFKNMCKLKPLLEKWLNDAESSPS---------DPSASTPSSYPTLSEVFGRKRKKRTSIET 283

  Fly   796 TVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRIN--------PSL---D 849
            .:|.||||.|..|.||:|||||.::|:|:|:|||:|||||||||||||||        |.:   .
Mouse   284 NIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPVKPPIYNSR 348

  Fly   850 LDSPTGT--PLSSHAFGYPPQALNMSHMQMEGGSGSFCG-------SSISSG 892
            |.||:|:  |||     .||     .|..|.|...|.|.       ||..||
Mouse   349 LVSPSGSLGPLS-----VPP-----VHSTMPGTVTSSCSPGNNSRPSSPGSG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm2	NP_001285877.1	POU	691..755	CDD:197673	60/63 (95%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	37/52 (71%)
Pou2f3	NP_035269.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		177/442 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..180		14/89 (16%)
		POU	176..250	CDD:197673	68/73 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..275		10/36 (28%)
		Homeobox	277..330	CDD:278475	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..419		16/49 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4663
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003004
OrthoInspector	1	1.000	-	-		mtm8890
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.870