DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdm2 and Pou4f2

DIOPT Version :9

Sequence 1:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_599182.1	Gene:	Pou4f2 / 171355	RGDID:	620075	Length:	412	Species:	Rattus norvegicus

Alignment Length:	326	Identity:	102/326 - (31%)
Similarity:	151/326 - (46%)	Gaps:	71/326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 LQNSL----QALAQFQALQQMKQQQREDP----------------LPSYSTPLAKS-PLRSPSLS 614
            |..||    :|||....:.|.|......|                :|..|...:.| |:..||..
  Rat   106 LDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSAL 170

  Fly   615 PVP----RHSKSQQRTPPNSMTANSL-----GMSSAVM------TPNTPSMQQQPQLQQSTPKPT 664
            ...    .|.......|..::....|     |::...|      ..:||:  ..|.:....|...
  Rat   171 AGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPA--HAPHMATMNPMHQ 233

  Fly   665 SGLTVASA---------MAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG--KLY 718
            :.|::|.|         |:.::..|      .:||.||:.|||||||||.||.|||.|:.  |:.
  Rat   234 AALSMAHAHGLPSHMGCMSDVDADP------RDLEAFAERFKQRRIKLGVTQADVGSALANLKIP 292

  Fly   719 G-NDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESI 782
            | ...||:||.|||:|.||..||..|||:||.|||:|:.:..:.              .:.||..
  Rat   293 GVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREK--------------LTKPELF 343

  Fly   783 LG-RRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINP 846
            .| .:::|||||....:.:||..|.:..:|:||:|:.::|:|::.|.|:||||||:|||:||:..
  Rat   344 NGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKY 408

  Fly   847 S 847
            |
  Rat   409 S 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm2	NP_001285877.1	POU	691..755	CDD:197673	39/66 (59%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	25/52 (48%)
Pou4f2	NP_599182.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..96
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q63934	94..240		25/135 (19%)
		POU-IV box	113..122		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..191		11/67 (16%)
		Nuclear speckle targeting signal. /evidence=ECO:0000250\|UniProtKB:Q12837	174..188		1/13 (8%)
		Required for DNA-binding and transcriptional repression. /evidence=ECO:0000250\|UniProtKB:Q63934	241..412		76/189 (40%)
		POU	253..330	CDD:197673	42/82 (51%)
		Homeobox	351..404	CDD:278475	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810