Protein Alignment pdm2 and Pou4f2

DIOPT Version :10

• Sequence 1: NP_723763.1
• Gene: pdm2 / 34673
• FlyBaseID: FBgn0004394
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_599182.1
• Gene: Pou4f2 / 171355
• RGDID: 620075
• Length: 412
• Species: Rattus norvegicus
• Alignment Length: 326
• Identity: 102/326 - (31%)
• Similarity: 151/326 - (46%)
• Gaps: 71/326 - (21%)

  Fly   571 LQNSL----QALAQFQALQQMKQQQREDP----------------LPSYSTPLAKS-PLRSPSLS 614
            |..||    :|||....:.|.|......|                :|..|...:.| |:..||..
  Rat   106 LDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSAL 170

  Fly   615 PVP----RHSKSQQRTPPNSMTANSL-----GMSSAVM------TPNTPSMQQQPQLQQSTPKPT 664
            ...    .|.......|..::....|     |::...|      ..:||:  ..|.:....|...
  Rat   171 AGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPA--HAPHMATMNPMHQ 233

  Fly   665 SGLTVASA---------MAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG--KLY 718
            :.|::|.|         |:.::..|      .:||.||:.|||||||||.||.|||.|:.  |:.
  Rat   234 AALSMAHAHGLPSHMGCMSDVDADP------RDLEAFAERFKQRRIKLGVTQADVGSALANLKIP 292

  Fly   719 G-NDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESI 782
            | ...||:||.|||:|.||..||..|||:||.|||:|:.:..:.              .:.||..
  Rat   293 GVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREK--------------LTKPELF 343

  Fly   783 LG-RRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINP 846
            .| .:::|||||....:.:||..|.:..:|:||:|:.::|:|::.|.|:||||||:|||:||:..
  Rat   344 NGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKY 408

  Fly   847 S 847
            |
  Rat   409 S 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pdm2	NP_723763.1	PHA03247	<375..675	CDD:223021	28/148 (19%)
		POU	691..755	CDD:197673	39/66 (59%)
		Homeodomain	787..843	CDD:459649	25/55 (45%)
Pou4f2	NP_599182.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..96
		Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q63934	94..240		25/135 (19%)
		POU-IV box	113..122		3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	123..191		11/67 (16%)
		Nuclear speckle targeting signal. /evidence=ECO:0000250|UniProtKB:Q12837	174..188		1/13 (8%)
		ACR_tran	<201..>289	CDD:481531	30/95 (32%)
		Required for DNA-binding and transcriptional repression. /evidence=ECO:0000250|UniProtKB:Q63934	241..412		76/189 (40%)
		POU	253..330	CDD:197673	42/82 (51%)
		Homeodomain	349..405	CDD:459649	25/55 (45%)